期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
乡村幼儿教师综合能力提升路径研究
1
作者 何菁 《黄冈职业技术学院学报》 2022年第5期33-36,共4页
2022年黄冈职业技术学院教育艺术学院组建黄冈市乡村幼儿师资培训团队,着手乡村幼儿教师培训的社会服务工作。为切实提升乡村幼儿教师的综合能力,聚焦乡村幼儿园现状,通过调研、讨论、交流、反馈等方式,提出研究前期诊断式调研,精准把脉... 2022年黄冈职业技术学院教育艺术学院组建黄冈市乡村幼儿师资培训团队,着手乡村幼儿教师培训的社会服务工作。为切实提升乡村幼儿教师的综合能力,聚焦乡村幼儿园现状,通过调研、讨论、交流、反馈等方式,提出研究前期诊断式调研,精准把脉;中期培训共培分治,对症下药;后期跟踪资源共建,疗效监控的三步走培训方式。旨在提升培训的科学性、针对性、有效性,切实提高乡村幼儿教师的专业能力,提升乡村幼儿园的整体办学水平。 展开更多
关键词 诊断式调研 共性共培 个性分治 乡村幼儿教师
下载PDF
Dawn of ocular gene therapy:implications for molecular diagnosis in retinal disease 被引量:4
2
作者 ZANEVELD Jacques WANG Feng +1 位作者 WANG Xia CHEN Rui 《Science China(Life Sciences)》 SCIE CAS 2013年第2期125-133,共9页
Personalized medicine aims to utilize genomic information about patients to tailor treatment. Gene replacement therapy for ra- re genetic disorders is perhaps the most extreme form of personalized medicine, in that th... Personalized medicine aims to utilize genomic information about patients to tailor treatment. Gene replacement therapy for ra- re genetic disorders is perhaps the most extreme form of personalized medicine, in that the patients' genome wholly determines their treatment regimen. Gene therapy for retinal disorders is poised to become a clinical reality. The eye is an optimal site for gene therapy due to the relative ease of precise vector delivery, immune system isolation, and availability for monitoring of any potential damage or side effects. Due to these advantages, clinical trials for gene therapy of retinal diseases are currently underway. A necessary precursor to such gene therapies is accurate molecular diagnosis of the mutation(s) underlying disease. In this review, we discuss the application of Next Generation Sequencing (NGS) to obtain such a diagnosis and identify disease causing genes, using retinal disorders as a case study. After reviewing ocular gene therapy, we discuss the application of NGS to the identification of novel Mendelian disease genes. We then compare current, array based mutation detection methods against next NGS-based methods in three retinal diseases: Leber's Congenital Amaurosis, Retinitis Pigmentosa, and Stargardt's disease. We conclude that next-generation sequencing based diagnosis offers several advantages over array based methods, including a higher rate of successful diagnosis and the ability to more deeply and efficiently assay a broad spectrum of mutations. However, the relative difficulty of interpreting sequence results and the development of standardized, reliable bioinforrnatic tools remain outstanding concerns. In this review, recent advances NGS based molecular diagnoses are discussed, as well as their implications for the development of personalized medicine. 展开更多
关键词 next-generation sequencing (NGS) retinal disease molecular diagnosis Leber's Congenital Amarosis (LCA) Retinitus Pigmentosa (RP) Stargardt disease APEX personal medicine
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部