Abstract： Taking the basic data and the log data of the various businesses of the automation integrated management system of the library in Jinan University as the research object this paper analyzes the internal rel...Abstract： Taking the basic data and the log data of the various businesses of the automation integrated management system of the library in Jinan University as the research object this paper analyzes the internal relationship between books and between the books and the readers, and designs a personalized book recommendation algorithm, the BookSimValue, on the basis of the user collaborative filteringtechnology. The experimental results show that the recommended book information produced by this algorithm can effectively help the readers to solve the problem of the book information overload, which can bring great convenience to the readers and effectively save the time of the readers＇ selection of the books, thus effectively improving the utilization of the library resources and the service levels.展开更多
Abacavir is an effective nucleoside analog reverse transcriptase inhibitor used to treat human immunodeficiency virus(HIV) infected patients.Its main side effect is hypersensitivity reaction(HSR).The incidence of the ...Abacavir is an effective nucleoside analog reverse transcriptase inhibitor used to treat human immunodeficiency virus(HIV) infected patients.Its main side effect is hypersensitivity reaction(HSR).The incidence of the HSR is associated with ethnicity among patients exposed to abacavir,and retrospective and prospective studies show a significantly increased risk of abacavir-induced HSR in human leukocyte antigen(HLA)-B*57:01-carrying patients.Immunological studies indicated that abacavir interacts specifically with HLA-B*57:01 and changed the binding specificity between the HLA molecule and the HLA-presented endogenous peptide repertoire,leading to a systemic autoimmune reaction.HLA-B*57:01 screening,combined with patch testing,had clinically predictive value and cost-effective impact in reducing the incidence of abacavir-induced HSR regardless of the HLA-B*57:01 prevalence in the population.Therefore,the US Food and Drug Administration(FDA) and international HIV treatment guidelines recommend a routine HLA-B*57:01 screening prior to abacavir treatment to decrease false positive diagnosis and prevent abacavir-induced HSR.The studies of abacavir-induced HSR and the implementation of the HLA-B*57:01 screening in the clinic represent a successful example of the use of pharmacogenetics for personalized diagnosis and therapy.展开更多
文摘Abstract： Taking the basic data and the log data of the various businesses of the automation integrated management system of the library in Jinan University as the research object this paper analyzes the internal relationship between books and between the books and the readers, and designs a personalized book recommendation algorithm, the BookSimValue, on the basis of the user collaborative filteringtechnology. The experimental results show that the recommended book information produced by this algorithm can effectively help the readers to solve the problem of the book information overload, which can bring great convenience to the readers and effectively save the time of the readers＇ selection of the books, thus effectively improving the utilization of the library resources and the service levels.
文摘Abacavir is an effective nucleoside analog reverse transcriptase inhibitor used to treat human immunodeficiency virus(HIV) infected patients.Its main side effect is hypersensitivity reaction(HSR).The incidence of the HSR is associated with ethnicity among patients exposed to abacavir,and retrospective and prospective studies show a significantly increased risk of abacavir-induced HSR in human leukocyte antigen(HLA)-B*57:01-carrying patients.Immunological studies indicated that abacavir interacts specifically with HLA-B*57:01 and changed the binding specificity between the HLA molecule and the HLA-presented endogenous peptide repertoire,leading to a systemic autoimmune reaction.HLA-B*57:01 screening,combined with patch testing,had clinically predictive value and cost-effective impact in reducing the incidence of abacavir-induced HSR regardless of the HLA-B*57:01 prevalence in the population.Therefore,the US Food and Drug Administration(FDA) and international HIV treatment guidelines recommend a routine HLA-B*57:01 screening prior to abacavir treatment to decrease false positive diagnosis and prevent abacavir-induced HSR.The studies of abacavir-induced HSR and the implementation of the HLA-B*57:01 screening in the clinic represent a successful example of the use of pharmacogenetics for personalized diagnosis and therapy.
