Cancer treatments are rapidly changing.Curative treatment for oesophageal adenocarcinoma currently involves surgery and cytotoxic chemotherapy or chemoradiotherapy.Outcomes for both regimes are generally poor as a res...Cancer treatments are rapidly changing.Curative treatment for oesophageal adenocarcinoma currently involves surgery and cytotoxic chemotherapy or chemoradiotherapy.Outcomes for both regimes are generally poor as a result of tumor recurrence.We have reviewed the key signalling pathways associated with oesophageal adenocarcinomas and discussed the recent trials of novel agents that attempt to target these pathways.There are many trials underway with the aim of improving survival in oesophageal cancer.Currently,phase 2 and 3 trials are focused on MAP kinase inhibition,either through inhibition of growth factor receptors or signal transducer proteins.In order to avoid tumor resistance,it appears to be clear that targeted therapy will be needed to combat the multiple signalling pathways that are in operation in oesophageal adenocarcinomas.This may be achievable in the future with the advent of gene signatures and a combinatorial approach.展开更多
The notion of invisibility in Invisible Man is spoken out by the protagonist＇s growth as an orator. Rather than a recursive retrieving of his identity throughout the narrative, the invisible man reinvents his identit...The notion of invisibility in Invisible Man is spoken out by the protagonist＇s growth as an orator. Rather than a recursive retrieving of his identity throughout the narrative, the invisible man reinvents his identity in his pursuit of pure persuasion. Both being terms in the Burkean system of literature rhetoric, pure persuasion, and identification become one for the unconscious purpose and the other for the symbolic action respectively in the protagonist-speaker＇s growth from an ideal emulator to speaker-audience mediator. In his identification with the audience and his ardent pursuit of pure persuasion, he paradoxically finds himself distanced from both his identity-to-be and the identity of his audience, with great division in-between. Though temporary corporation is achieved and occasional identification is resolved in the last two speeches, the protagonist only finds himself in a rhetorical context which is much more varied and more manipulative than he imagined. Such a realization renders the invisible man invisible again from the public stadium, who decides to resort to the pen for a life-long identification with the broader battlefield of racial discontinuity展开更多
Methods to measure consistent individual differences in behavior （i.e. animal personality） fall into two categories, subjective ratings and behavioral codings. Ratings are seldom used despite being potentially more ...Methods to measure consistent individual differences in behavior （i.e. animal personality） fall into two categories, subjective ratings and behavioral codings. Ratings are seldom used despite being potentially more efficient than codings. One potential limitation for the use of ratings is that it is assumed that long-term observers or experts in the field are required to score individuals. This can be problematic in many cases, especially for long-term ecological studies where there is high turnover in personnel. We tested whether raters who were unacquainted with subjects could produce reliable and valid personality assessments of yellow-bellied marmots Marmota flaviventris. Two raters, previously unacquainted with individuals and marmot be- havior, scored 130 subjects on fifteen different adjectives in both open-field （OF） and mirror image stimulation （MIS） trials. Eight OF and nine MIS adjectives were reliable as indicated by both a high degree of intra-observer and inter-observer reliability. Additionally, some ratings were externally valid, correlating with behavioral codings. Our data suggest that activity/exploration and sociability can be a reliable and valid measurement of personality traits in studies where raters were unacquainted with subjects. These traits are observable with the personality tests we used; otherwise researchers using unacquainted raters should be cautious in the tests they employ [Current Zoology 60 （2）： 162-169, 2014].展开更多
基金Supported by UK National Institute of Health Research/Cancer Research Network (UK NIHR/UKCRN) and Research and Development Department of Wrightington Wigan and Leigh NHS Foundation Trust (to Ang YS)R Keld WrightingtonWigan and Leigh NHS Foundation Trust Cancer Therapy Fund(to Keld RR,in part)
文摘Cancer treatments are rapidly changing.Curative treatment for oesophageal adenocarcinoma currently involves surgery and cytotoxic chemotherapy or chemoradiotherapy.Outcomes for both regimes are generally poor as a result of tumor recurrence.We have reviewed the key signalling pathways associated with oesophageal adenocarcinomas and discussed the recent trials of novel agents that attempt to target these pathways.There are many trials underway with the aim of improving survival in oesophageal cancer.Currently,phase 2 and 3 trials are focused on MAP kinase inhibition,either through inhibition of growth factor receptors or signal transducer proteins.In order to avoid tumor resistance,it appears to be clear that targeted therapy will be needed to combat the multiple signalling pathways that are in operation in oesophageal adenocarcinomas.This may be achievable in the future with the advent of gene signatures and a combinatorial approach.
文摘The notion of invisibility in Invisible Man is spoken out by the protagonist＇s growth as an orator. Rather than a recursive retrieving of his identity throughout the narrative, the invisible man reinvents his identity in his pursuit of pure persuasion. Both being terms in the Burkean system of literature rhetoric, pure persuasion, and identification become one for the unconscious purpose and the other for the symbolic action respectively in the protagonist-speaker＇s growth from an ideal emulator to speaker-audience mediator. In his identification with the audience and his ardent pursuit of pure persuasion, he paradoxically finds himself distanced from both his identity-to-be and the identity of his audience, with great division in-between. Though temporary corporation is achieved and occasional identification is resolved in the last two speeches, the protagonist only finds himself in a rhetorical context which is much more varied and more manipulative than he imagined. Such a realization renders the invisible man invisible again from the public stadium, who decides to resort to the pen for a life-long identification with the broader battlefield of racial discontinuity
文摘Methods to measure consistent individual differences in behavior （i.e. animal personality） fall into two categories, subjective ratings and behavioral codings. Ratings are seldom used despite being potentially more efficient than codings. One potential limitation for the use of ratings is that it is assumed that long-term observers or experts in the field are required to score individuals. This can be problematic in many cases, especially for long-term ecological studies where there is high turnover in personnel. We tested whether raters who were unacquainted with subjects could produce reliable and valid personality assessments of yellow-bellied marmots Marmota flaviventris. Two raters, previously unacquainted with individuals and marmot be- havior, scored 130 subjects on fifteen different adjectives in both open-field （OF） and mirror image stimulation （MIS） trials. Eight OF and nine MIS adjectives were reliable as indicated by both a high degree of intra-observer and inter-observer reliability. Additionally, some ratings were externally valid, correlating with behavioral codings. Our data suggest that activity/exploration and sociability can be a reliable and valid measurement of personality traits in studies where raters were unacquainted with subjects. These traits are observable with the personality tests we used; otherwise researchers using unacquainted raters should be cautious in the tests they employ [Current Zoology 60 （2）： 162-169, 2014].
