Traffic jam in large signalized road network presents a complex nature.In order to reveal the jam characteristics,two indexes,SVS(speed of virtual signal) and VOS(velocity of spillover),were proposed respectively.SVS ...Traffic jam in large signalized road network presents a complex nature.In order to reveal the jam characteristics,two indexes,SVS(speed of virtual signal) and VOS(velocity of spillover),were proposed respectively.SVS described the propagation of queue within a link while VOS reflected the spillover velocity of vehicle queue.Based on the two indexes,network jam simulation was carried out on a regular signalized road network.The simulation results show that:1) The propagation of traffic congestion on a signalized road network can be classified into two stages:virtual split driven stage and flow rate driven stage.The former stage is characterized by decreasing virtual split while the latter only depends on flow rate; 2) The jam propagation rate and direction are dependent on traffic demand distribution and other network parameters.The direction with higher demand gets more chance to be jammed.Our findings can serve as the basis of the prevention of the formation and propagation of network traffic jam.展开更多
In this paper the author examines the extent to which word of mouth （WOM） impact on customer equity and brand equity, two of the most popular metrics of marketing productivity. WOM is the most ancient and effective ...In this paper the author examines the extent to which word of mouth （WOM） impact on customer equity and brand equity, two of the most popular metrics of marketing productivity. WOM is the most ancient and effective communication tool because its low cost affects the efficiency in the allocation of marketing resources. After an extensive literature review, the author proposes several propositions to be tested in the future concerning how WOM might affect each element of brand equity and customer equity.展开更多
AIM To evaluate associations between mi RNA target genes IL12B,INSR,CCND1 and IL10 polymorphisms and gastric cancer(GC)in European population.METHODS Gene polymorphisms were analyzed in 508 controls and474 GC patients...AIM To evaluate associations between mi RNA target genes IL12B,INSR,CCND1 and IL10 polymorphisms and gastric cancer(GC)in European population.METHODS Gene polymorphisms were analyzed in 508 controls and474 GC patients from 3 tertiary centers in Germany,Lithuania and Latvia.Controls were patients from the out-patient departments,who were referred for upper endoscopy because of dyspeptic symptoms and had no history of previous malignancy.Gastric cancer(GC)patients had histopathological verification of gastric adenocarcinoma.Genomic DNA was extracted using salting out method from peripheral blood mononuclear cells.IL12B T>G(rs1368439),INSR T>C(rs1051690),CCND1 A>C(rs7177)and IL10 T>C(rs3024498)SNPs were genotyped by the real-time polymerase chain reaction.Associations between gene polymorphism and GC were evaluated using multiple logistic regression analysis with adjustment for sex,age and country of birth.RESULTS We observed similar distribution of genotypes and allelic frequencies of all polymorphisms between GC patients and controls except of INSR rs1051690.The frequency of the T allele of INSR gene was significantly higher in GC patients than in controls(23.26%and 19.19%respectively,P=0.028).CT genotype was also more prevalent in patients compared to control group(38.48%and 30.12%respectively,P<0.021).Logistic regression analysis revealed that only one polymorphism(rs1051690 in INSR gene)was associated with increased risk of GC.Carriers of CT genotype had higher odds of GC when compared to CC genotype(OR=1.45,95%PI:1.08-1.95,P=0.01).Similar association was observed in a dominant model for INSR gene,where comparison of TT+CT vs CC genotypes showed an increased risk of GC(OR=1.44,95%PI:1.08-1.90,P=0.01).Other analyzed SNPs were not associated with the presence of GC.CONCLUSION INSR rs1051690 SNP is associated with increased risk of GC,while polymorphisms in IL12B,CCND1 and IL10genes are not linked with the presence of GC.展开更多
Familial intrahepatic cholestasis(FIC) comprises a group of rare cholestatic liver diseases associated with canalicular transport defects resulting predominantly from mutations in ATP8B1, ABCB11 and ABCB4. Phe-notypes...Familial intrahepatic cholestasis(FIC) comprises a group of rare cholestatic liver diseases associated with canalicular transport defects resulting predominantly from mutations in ATP8B1, ABCB11 and ABCB4. Phe-notypes range from benign recurrent intrahepatic cholestasis(BRIC), associated with recurrent cholestatic attacks, to progressive FIC(PFIC). Patients often suffer from severe pruritus and eventually progressive cholestasis results in liver failure. Currently, first-line treatment includes ursodeoxycholic acid in patients with ABCB4 deficiency(PFIC3) and partial biliary diversion in patients with ATP8B1 or ABCB11 deficiency(PFIC1 and PFIC2). When treatment fails, liver transplantation is needed which is associated with complications like rejection, post-transplant hepatic steatosis and recurrence of disease. Therefore, the need for more and better therapies for this group of chronic diseases remains. Here, we discuss new symptomatic treatment options like total biliary diversion, pharmacological diversion of bile acids and hepatocyte transplantation. Furthermore, we focus on emerging mutation-targeted therapeutic strategies, providing an outlook for future personalized treatment for inherited cholestatic liver diseases.展开更多
This study is the design guidelines for the living space with robots. The study can be applied to the architectural planning and focused on the basic environmental primary factor. The authors focused on space size, sp...This study is the design guidelines for the living space with robots. The study can be applied to the architectural planning and focused on the basic environmental primary factor. The authors focused on space size, specifical distance from the wall in the front direction, position, and distance between an individual as factors affecting individual distance. The authors research the distances a small mobile robot moves to a six mats space compared with that toward a distances 5 m or more （space less physical factors）. The following three results were obtained： （1） The individual distance is smaller than 30 cm in both the approach angle in the experiment space of six mats; （2） The distance from the wall in the front increased, and the individual distance between a participant and a robot also increased; （3） In terms of body position, the upright positioning was clarified and the individual distance was small.展开更多
Many researchers confirm that confidence factor plays a significant role in oral English training. However, lack of reliable evaluation methods renders teachers impotent in measuring individual confidence variation. T...Many researchers confirm that confidence factor plays a significant role in oral English training. However, lack of reliable evaluation methods renders teachers impotent in measuring individual confidence variation. They can do little more than form a rough impression on the basis of students' test scores and their personality traits, which proves deceptive and misleading. This paper introduces the notion of confidence index as an evaluation criterion, and empirical investigation reveals the wide variation in individual confidence index. Finally this paper explores the correlation between confidence factor and proficiency.展开更多
We study for a class of symmetric Levy processes with state space R^n the transition density pt（x） in terms of two one-parameter families of metrics, （dt）t〉o and （δt）t〉o. The first family of metrics describes...We study for a class of symmetric Levy processes with state space R^n the transition density pt（x） in terms of two one-parameter families of metrics, （dt）t〉o and （δt）t〉o. The first family of metrics describes the diagonal term pt （0）; it is induced by the characteristic exponent ψ of the Levy process by dr（x, y） = √tψ（x - y）. The second and new family of metrics 6t relates to √tψ through the formula exp（-δ^2t（x,y））=F[e^-tψ/pt（0）]（x-y）,where Y denotes the Fourier transform. Thus we obtain the following ＂Gaussian＂ representation of the tran- sition density： pt（x） = pt（O）e^-δ^2t（x,0） where pt（O） corresponds to a volume term related to √tψ and where an ＂exponential＂ decay is governed by 5t2. This gives a complete and new geometric, intrinsic interpretation of pt（x）.展开更多
基金Project(2012CB725402)supported by the State Key Development Program for Basic Research of ChinaProject(2012MS21175)supported by the National Science Foundation for Post-doctoral Scientists of ChinaProject(Bsh1202056)supported by the Excellent Postdoctoral Science Foundation of Zhejiang Province,China
文摘Traffic jam in large signalized road network presents a complex nature.In order to reveal the jam characteristics,two indexes,SVS(speed of virtual signal) and VOS(velocity of spillover),were proposed respectively.SVS described the propagation of queue within a link while VOS reflected the spillover velocity of vehicle queue.Based on the two indexes,network jam simulation was carried out on a regular signalized road network.The simulation results show that:1) The propagation of traffic congestion on a signalized road network can be classified into two stages:virtual split driven stage and flow rate driven stage.The former stage is characterized by decreasing virtual split while the latter only depends on flow rate; 2) The jam propagation rate and direction are dependent on traffic demand distribution and other network parameters.The direction with higher demand gets more chance to be jammed.Our findings can serve as the basis of the prevention of the formation and propagation of network traffic jam.
文摘In this paper the author examines the extent to which word of mouth （WOM） impact on customer equity and brand equity, two of the most popular metrics of marketing productivity. WOM is the most ancient and effective communication tool because its low cost affects the efficiency in the allocation of marketing resources. After an extensive literature review, the author proposes several propositions to be tested in the future concerning how WOM might affect each element of brand equity and customer equity.
基金Supported by Lithuanian Research Council Grant,No.MIP-14418
文摘AIM To evaluate associations between mi RNA target genes IL12B,INSR,CCND1 and IL10 polymorphisms and gastric cancer(GC)in European population.METHODS Gene polymorphisms were analyzed in 508 controls and474 GC patients from 3 tertiary centers in Germany,Lithuania and Latvia.Controls were patients from the out-patient departments,who were referred for upper endoscopy because of dyspeptic symptoms and had no history of previous malignancy.Gastric cancer(GC)patients had histopathological verification of gastric adenocarcinoma.Genomic DNA was extracted using salting out method from peripheral blood mononuclear cells.IL12B T>G(rs1368439),INSR T>C(rs1051690),CCND1 A>C(rs7177)and IL10 T>C(rs3024498)SNPs were genotyped by the real-time polymerase chain reaction.Associations between gene polymorphism and GC were evaluated using multiple logistic regression analysis with adjustment for sex,age and country of birth.RESULTS We observed similar distribution of genotypes and allelic frequencies of all polymorphisms between GC patients and controls except of INSR rs1051690.The frequency of the T allele of INSR gene was significantly higher in GC patients than in controls(23.26%and 19.19%respectively,P=0.028).CT genotype was also more prevalent in patients compared to control group(38.48%and 30.12%respectively,P<0.021).Logistic regression analysis revealed that only one polymorphism(rs1051690 in INSR gene)was associated with increased risk of GC.Carriers of CT genotype had higher odds of GC when compared to CC genotype(OR=1.45,95%PI:1.08-1.95,P=0.01).Similar association was observed in a dominant model for INSR gene,where comparison of TT+CT vs CC genotypes showed an increased risk of GC(OR=1.44,95%PI:1.08-1.90,P=0.01).Other analyzed SNPs were not associated with the presence of GC.CONCLUSION INSR rs1051690 SNP is associated with increased risk of GC,while polymorphisms in IL12B,CCND1 and IL10genes are not linked with the presence of GC.
文摘Familial intrahepatic cholestasis(FIC) comprises a group of rare cholestatic liver diseases associated with canalicular transport defects resulting predominantly from mutations in ATP8B1, ABCB11 and ABCB4. Phe-notypes range from benign recurrent intrahepatic cholestasis(BRIC), associated with recurrent cholestatic attacks, to progressive FIC(PFIC). Patients often suffer from severe pruritus and eventually progressive cholestasis results in liver failure. Currently, first-line treatment includes ursodeoxycholic acid in patients with ABCB4 deficiency(PFIC3) and partial biliary diversion in patients with ATP8B1 or ABCB11 deficiency(PFIC1 and PFIC2). When treatment fails, liver transplantation is needed which is associated with complications like rejection, post-transplant hepatic steatosis and recurrence of disease. Therefore, the need for more and better therapies for this group of chronic diseases remains. Here, we discuss new symptomatic treatment options like total biliary diversion, pharmacological diversion of bile acids and hepatocyte transplantation. Furthermore, we focus on emerging mutation-targeted therapeutic strategies, providing an outlook for future personalized treatment for inherited cholestatic liver diseases.
文摘This study is the design guidelines for the living space with robots. The study can be applied to the architectural planning and focused on the basic environmental primary factor. The authors focused on space size, specifical distance from the wall in the front direction, position, and distance between an individual as factors affecting individual distance. The authors research the distances a small mobile robot moves to a six mats space compared with that toward a distances 5 m or more （space less physical factors）. The following three results were obtained： （1） The individual distance is smaller than 30 cm in both the approach angle in the experiment space of six mats; （2） The distance from the wall in the front increased, and the individual distance between a participant and a robot also increased; （3） In terms of body position, the upright positioning was clarified and the individual distance was small.
文摘Many researchers confirm that confidence factor plays a significant role in oral English training. However, lack of reliable evaluation methods renders teachers impotent in measuring individual confidence variation. They can do little more than form a rough impression on the basis of students' test scores and their personality traits, which proves deceptive and misleading. This paper introduces the notion of confidence index as an evaluation criterion, and empirical investigation reveals the wide variation in individual confidence index. Finally this paper explores the correlation between confidence factor and proficiency.
文摘We study for a class of symmetric Levy processes with state space R^n the transition density pt（x） in terms of two one-parameter families of metrics, （dt）t〉o and （δt）t〉o. The first family of metrics describes the diagonal term pt （0）; it is induced by the characteristic exponent ψ of the Levy process by dr（x, y） = √tψ（x - y）. The second and new family of metrics 6t relates to √tψ through the formula exp（-δ^2t（x,y））=F[e^-tψ/pt（0）]（x-y）,where Y denotes the Fourier transform. Thus we obtain the following ＂Gaussian＂ representation of the tran- sition density： pt（x） = pt（O）e^-δ^2t（x,0） where pt（O） corresponds to a volume term related to √tψ and where an ＂exponential＂ decay is governed by 5t2. This gives a complete and new geometric, intrinsic interpretation of pt（x）.
