阿片类癌痛止痛药的中医性能探讨

据世界卫生组织（WHO）统计,全世界每年有1 000万新发癌症患者,600万人死于癌症,其中50%的患者有癌性疼痛症状,70%的晚期癌症患者以疼痛为主要症状[1]。疼痛已作为四大生命体征之后的第五大生命体征,对患者的生存质量有严重影响,所以控制疼痛对癌症患者很重要[2]。目前对于癌性疼痛的控制,

中医药高性能计算公共服务平台的建设与探索

科学计算是继理论和实验之后人类认识世界的第三大方法 ,服务于科学计算的高性能计算技术是伴随着电子计算机的出现迅速发展并获得广泛应用的新兴交叉学科,是信息领域的前沿高技术,是衡量一个国家综合实力的重要标志之一。

中医药领域高性能计算的引进及应用情况介绍

高性能计算是计算机科学的一个分支,研究并行算法和开发相关软件,致力于开发高性能计算机。在科学技术迅猛发展的今天,高性能计算已经成为科学技术发展和重大工程设计中具有战略意义的研究手段。

TREATMENT OF COMPLICATIONS DUE TO PERITONEAL DIALYSIS FOR CHRONIC RENAL FAILURE WITH TRADITIONAL CHINESE MEDICINE

In this paper,the experience in the treatment of complications due to continuousambulatory peritoneal dialysis for chronic renal failure with traditional Chinese medicine(TCM)is reported.Modified Renshen Yangrong Tang(Ginseng Nutrition Decoction)wasused for anorexia and hypoproteinemia;modified Xiangsha Liujunzi Tang(Decoction ofCyperus and Amomum with Six Noble Ingredients)for abdominal pain and distension;modified Da Chaihu Tang(Major Bupleurum Decoction)for peritonitis;modifiedShenling Baizhu San(Powder of Ginseng,Poria and Atractylodes)for diarrhea due toinsufficiency of the spleen with abundance of dampness;Lizhong Tang(Decoction forRegulating the Function of Middle-jiao)and modified Sishen Wan(Pills of FourMiraculous Drugs)for insufficiency of both the spleen and the kidney;Siwu Tang(Decoction of Four Ingredients)added with other drugs for cutaneous pruritus,andGuishao Sijunzi Tang(Decoction of Four Noble Drugs added with Chinese Angelica Rootand white Peony Root)for renal anemia.The therapeutic principles of invigorating theliver and kidney,strengthening the bones and muscles,and promoting blood circulation toeliminate blood stasis were adopted in the treatment of renal osteopathy,and thetherapeutic principles of invigorating the liver and kidney,expelling phlegm and resolvingdampness,and promoting blood circulation to eliminate blood stasis in the treatment ofhyperlipemia.Shen Tekang capsules(capsules for improving the renal function)wasadministered to patients for strengthening the viability and improving the nutrition state,and the recipe for treating renal function failure(both formulated by the authors)forimproving the renal function so as to decrease the frequency and duration of dialysis.

OBSERVATION ON THE THERAPEUTIC EFFECT OF BIRD-PECKING MOXIBUSTION OF SPECIFIC ACUPOINTS IN THE TREATMENT OF FUNCTIONAL DYSPEPSIA

Objective: To observe the therapeutic effect of moxibustion of some specific acupoints for treatment of functional dyspepsia (FD, qi-distension type). Methods:A total of 50 cases of FD patients were randomly divided into treatment group (n=26) and medication group (n=24). In treatment group, bird-pecking moxibustion was applied to Zhongwan (CV 12), Qihai (CV 6), Neiguan (PC 6) and Gongsun (SP 4) 5～6 times in every treatment till the local skin got flush. The treatment was given once daily, continuously for 10 days. In control group, the patients were ordered to take Motilium 10 mg/time, 3 times daily. Following 10 days’ treatment the therapeutic effect was assessed.Results:After treatment, of the 26 cases in treatment group, 11 (42.3%) were cured, 7 (26.92%) had remarkable improvement in their symptoms, 6 (23.07%) had improvement and 2 (7.69%) failed, with a total effective rate of 92.31%. Of the 24 cases in medication group, 9 (37.50%) were cured, 6 (25.00%) experienced remarkable improvement in their symptoms, 6 (25.00%) were improved and 3 (12.50%) failed, with a total effective rate of 87.50%. Comparison between two groups showed that the therapeutic effect of moxibustion was significantly superior to that of medication (P<0.05). In addition, the difference value of the therapeutic effect index (TEI) between post-and pre-treatment in treatment group was also significantly higher than that of medication group (P<0.05). Conclusion: Bird-pecking moxibustion of specific acupoints can effectively improve clinical symptoms of FD patients.

Performance modeling of positive degraded task-pair with helper-thread in CMP

Helper-thread of a task can hide the memory access time of irregular data on the chip muhi-core processor （CMP）. For constructing a compiler that effectively supports the helper-thread of a task in the multi-core scenario based on the last level shared cache, this paper studies its performance stable condi- tions. Unfortunately, there is no existing model that allows extensive investigation of the impact of stable conditions, we present the base of pre-computation that is formalized by our degraded task-pair 〈 T, T＇ 〉 with the helper-thread, and its stable conditions are analyzed. Finally, a novel performance model and a constructing method of pre-computation based on our positive degraded task-pair are proposed. The efficient results are shown by our experiments. If we further exploit memory level parallelism （MLP） for our task-pair, the task-pair 〈 T, T＇ 〉 can reach better performance.

Performance Analysis of Integrative QoS Scheme for Routers

This paper proposes an integrative scheme of DiffServ （differentiated service） for the IP-based network. In the scheme, QoS （Quality of Service） is ranked according to the level of both the queuing delay and the drop precedence that base on the relative differentiated service; it does not take the resource reservation problem into consideration for making its implementation more simple and flexible. We will propose an implemented architecture including edge routers and core routers, and the PHB （per-hop-behavior） architecture of the routers is generalized. We adopt ERED （extended random early discard） mechanism for drop precedence and use proportional delay differentiation for queuing delay. In the proportional delay differentiation topic, we propose a new WTP （waiting time priority）-like algorithm. Besides, a new stochastic petri net model of the PHB model is given, and the performance of whole implemented PHB architecture is analyzed, too.

Clinical characteristics of 96 patients with drug-induced acute liver failure:a comparison between Traditional Chinese and Western Medicine

OBJECTIVE: To compare the causes, clinical symptoms, laboratory test results, and prognosis in patients with acute liver failure(ALF) induced by traditional Chinese medicines(TCM) and by Western Medicines(WM).METHODS: The medical histories of patients who were diagnosed with drug-induced ALF(DALF)(n =96) after hospitalization in the 302 Military Hospital between January 2010 and December 2015 were retrospectively examined.RESULTS: Fifty-eight of the 96 DALF patients(60.4%) had a hepatocellular pattern of DALF, 16 patients(16.7%) had a cholestatic pattern, and 22 patients(22.9%) had a mixed pattern. DALF resolved in 24 patients(25.0%). Twenty-five patients(26.0%)developed chronic liver injury, 43 patients(44.8%)died, and 4 patients(4.2%) underwent liver transplantation. There were 42 ALF patients(43.8%) who received WM, and 32 ALF patients(33.3%) who received TCM. TCM-induced ALF patients had a higher average age [42.4 ± 18.4) vs(33.5 ± 17.9) years,P = 0.04] and higher creatinine and urine nitrogen levels [(155.2 ± 108.8) vs(97.5 ± 130.4) mmol/L, P =0.047;(9.1 ± 7.7) vs(4.3 ± 5.0) mmol/L, P = 0.002, respectively]. Patients with TCM-induced ALF exhibited an increased risk of renal injury [odds ratio(OR),3.75; 95% confidence interval(CI), 1.330-10.577].The 14 patients with TCM-induced ALF who died exhibited higher creatinine levels than the 18 patients with TCM-induced ALF patients who survived[(218.7 ± 111.6) vs(105.8 ± 78.4) mmol/L, P =0.002]. They were also more likely to exhibit ascites(85.7% vs 44.4%, P = 0.017) and hepatorenal syndrome(78.6% vs 22.2%, P = 0.002).CONCLUSION: TCM-induced ALF was more likely to be accompanied by renal injury than was WM-induced ALF, especially in TCM-induced ALF patients who died.

Assessment of the safety and efficacy of acupuncture in erectile dysfunction treatment

Objective To assess the safety and efficacy of acupuncture in erectile dysfunction treatment.Methods A systematic literature search was conducted to identify relevant studies.Seven electronic databases including Popline,World Health Organization(WHO)Global Health Library(GHL),System for Information on Grey Literature in Europe(SIGLE),Scopus,Institute for Scientific Information(ISI)Web of Science,PubMed and Virtual Health Library(VHL)were utilized to carry out the search.A manual search was further conducted for relevant publications from references of the included articles,relevant papers in PubMed and Google Scholar,and primary studies that had cited the included papers.Hand-search using each keyword to avoid missing any relevant publications was also carried out.Results The literature search yielded 2818 reports after removing duplicates using Endnote software.There were 21 studies eligible for full-text screening and five of which were subsequently included.After two studies identified from the manual search were added,a total of seven studies were found suitable to carry out the systematic review and meta-analysis.Five of them were used for quantitative and qualitative analysis,while two were only used for qualitative analysis.There were four clinical trials,one pilot study,one case report,and one animal study.Conclusion Acupuncture can improve male erectile function.