Granulomatous mastitis(GM)is a benign granulomatous condition,and its pathogenesis may be related to autoimmune disorders.Cellular immunity,humoral immunity,immunoglobulins,and complement could all play a role in the ...Granulomatous mastitis(GM)is a benign granulomatous condition,and its pathogenesis may be related to autoimmune disorders.Cellular immunity,humoral immunity,immunoglobulins,and complement could all play a role in the disease process,showing certain clinical patterns.Corticosteroids can quickly control disease progression,and immunosuppressants can be used for complex and refractory GM cases.In traditional Chinese medicine(TCM),“healthy qi”is similar to immune system function.For GM with deficient healthy qi,TCM treatments such as internal and external herbal applications can help regulate immune function and shorten disease duration by staged and TCM treatment,regulating viscera,reinforcing healthy qi,and eliminating pathogenic factors.展开更多
目的：探讨中药自拟方治疗分期治疗股骨头坏死（osteonecrosis of the femoral head，ONFH）的临床疗效。方法收集2010年7月至2013年7月本院骨科住院早、中期ONFH患者106例，采用随机数字表法将患者随机分为两组各53例，治疗组患者早期...目的：探讨中药自拟方治疗分期治疗股骨头坏死（osteonecrosis of the femoral head，ONFH）的临床疗效。方法收集2010年7月至2013年7月本院骨科住院早、中期ONFH患者106例，采用随机数字表法将患者随机分为两组各53例，治疗组患者早期服用自拟健脾活血方，中期服用自拟补肾活血方治疗；对照组口服仙灵骨葆胶囊与洛伐他汀胶囊治疗。两组均治疗6周为1个疗程，治疗2个疗程后评价临床疗效和血液流变学指标。结果治疗后治疗组总有效率为90.6%（48/53），对照组为73.6%（39/53），两组总有效率比较，差异有统计学意义（χ^2＝6.731，P＜0.05）。治疗后治疗组全血黏度高切、中切、低切，血浆黏度（PV）、红细胞压积（HCT）、红细胞聚集指数（Arbe）、红细胞沉降率（ESR）、纤维蛋白原（FIB）[（3.42±0.72）mPa·S、（4.21±0.30）mPa·S、（8.36±0.12）mPa·S、（1.39±0.16）mPa·S、（38.34±2.37）%、（5.47±0.33）、（27.35±2.16）mm/h、（3.83±0.47）g/L]均较同组治疗前[（3.97±0.21）mPa·S、（4.71±0.24）mPa·S、（9.58±0.31）mPa·S、（2.01±0.13）mPa·S、（41.29±1.01）%、（6.51±0.21）、（14.62±0.92）mm/h、（4.94±0.26）g/L]明显改善（ P＜0.05）；且治疗组各检测指标与对照组[（3.76±0.08）mPa·S、（4.47±0.16）mPa·S、（8.99±0.07）mPa·S 、（1.72±0.14）mPa·S 、（40.46±1.06）%、（6.11±0.38）、（24.98±1.42）mm/h 、（4.33±0.57）g/L]比较，差异均有统计学意义（P＜0.01或0.05）。结论中药自拟方分期治疗可改善ONFH患者血液流变学指标，提高骨密度，促进骨小梁生长。展开更多
基金supported by the 2022 National Clinical Research Base“Top List”Special Project of the Health Commission of Henan Province(2022JDZX086)2021 National Clinical Research Base Research Special Project of the Health Commission of Henan Province(2021JDZY018)National Distinguished and Veteran TCM Experts Inheritance Studio Construction Project of the National Administration of Traditional ChineseMedicine(2100601-CZ0175).
文摘Granulomatous mastitis(GM)is a benign granulomatous condition,and its pathogenesis may be related to autoimmune disorders.Cellular immunity,humoral immunity,immunoglobulins,and complement could all play a role in the disease process,showing certain clinical patterns.Corticosteroids can quickly control disease progression,and immunosuppressants can be used for complex and refractory GM cases.In traditional Chinese medicine(TCM),“healthy qi”is similar to immune system function.For GM with deficient healthy qi,TCM treatments such as internal and external herbal applications can help regulate immune function and shorten disease duration by staged and TCM treatment,regulating viscera,reinforcing healthy qi,and eliminating pathogenic factors.
文摘目的：探讨中药自拟方治疗分期治疗股骨头坏死（osteonecrosis of the femoral head，ONFH）的临床疗效。方法收集2010年7月至2013年7月本院骨科住院早、中期ONFH患者106例，采用随机数字表法将患者随机分为两组各53例，治疗组患者早期服用自拟健脾活血方，中期服用自拟补肾活血方治疗；对照组口服仙灵骨葆胶囊与洛伐他汀胶囊治疗。两组均治疗6周为1个疗程，治疗2个疗程后评价临床疗效和血液流变学指标。结果治疗后治疗组总有效率为90.6%（48/53），对照组为73.6%（39/53），两组总有效率比较，差异有统计学意义（χ^2＝6.731，P＜0.05）。治疗后治疗组全血黏度高切、中切、低切，血浆黏度（PV）、红细胞压积（HCT）、红细胞聚集指数（Arbe）、红细胞沉降率（ESR）、纤维蛋白原（FIB）[（3.42±0.72）mPa·S、（4.21±0.30）mPa·S、（8.36±0.12）mPa·S、（1.39±0.16）mPa·S、（38.34±2.37）%、（5.47±0.33）、（27.35±2.16）mm/h、（3.83±0.47）g/L]均较同组治疗前[（3.97±0.21）mPa·S、（4.71±0.24）mPa·S、（9.58±0.31）mPa·S、（2.01±0.13）mPa·S、（41.29±1.01）%、（6.51±0.21）、（14.62±0.92）mm/h、（4.94±0.26）g/L]明显改善（ P＜0.05）；且治疗组各检测指标与对照组[（3.76±0.08）mPa·S、（4.47±0.16）mPa·S、（8.99±0.07）mPa·S 、（1.72±0.14）mPa·S 、（40.46±1.06）%、（6.11±0.38）、（24.98±1.42）mm/h 、（4.33±0.57）g/L]比较，差异均有统计学意义（P＜0.01或0.05）。结论中药自拟方分期治疗可改善ONFH患者血液流变学指标，提高骨密度，促进骨小梁生长。
