The ethanolic extracts of 100 common traditional Chinese drugs, which are widely used in many prescriptions in treatment of cancer in China, were screened for MDR of KBV200 cell line in vitro with MTT method. The ...The ethanolic extracts of 100 common traditional Chinese drugs, which are widely used in many prescriptions in treatment of cancer in China, were screened for MDR of KBV200 cell line in vitro with MTT method. The result showed 9 extracts having MDR reversal activity. They were the extracts of Fructus Lagenariae Sicerariae, Radix Glycyrrhizae, Poria, Herba Andrographitis, Radix Sophorae Tonkinensis, Caulis Mahoniae, Folium Artemisiae Argyi, Rhizoma Curcumae, Fructus Cnidii. Other 5 extracts showed cytotoxic on KBV200 cell line. $$$$展开更多
The above therapeutic results show that TCM drugs have excellent effects in counteracting the metastasis of tumors. They can produce a synergistic effect when used together with surgery, radio- and chemotherapy. In an...The above therapeutic results show that TCM drugs have excellent effects in counteracting the metastasis of tumors. They can produce a synergistic effect when used together with surgery, radio- and chemotherapy. In analyzing the relationship between the factors that affect the distant metastasis, the authors strongly recommend that the FDM-survival rate be used, i.e. the survival rate free from distant metastasis as suggested by Hong Minghuang et al in their article. An analysis based on FDM-survival rate in a duration of three or five years with the data treated with the Kaplan-Meier and/or Life Table would be rational and convincible.展开更多
基金support of National Natural Science Foundation of China(39970892)
文摘The ethanolic extracts of 100 common traditional Chinese drugs, which are widely used in many prescriptions in treatment of cancer in China, were screened for MDR of KBV200 cell line in vitro with MTT method. The result showed 9 extracts having MDR reversal activity. They were the extracts of Fructus Lagenariae Sicerariae, Radix Glycyrrhizae, Poria, Herba Andrographitis, Radix Sophorae Tonkinensis, Caulis Mahoniae, Folium Artemisiae Argyi, Rhizoma Curcumae, Fructus Cnidii. Other 5 extracts showed cytotoxic on KBV200 cell line. $$$$
文摘The above therapeutic results show that TCM drugs have excellent effects in counteracting the metastasis of tumors. They can produce a synergistic effect when used together with surgery, radio- and chemotherapy. In analyzing the relationship between the factors that affect the distant metastasis, the authors strongly recommend that the FDM-survival rate be used, i.e. the survival rate free from distant metastasis as suggested by Hong Minghuang et al in their article. An analysis based on FDM-survival rate in a duration of three or five years with the data treated with the Kaplan-Meier and/or Life Table would be rational and convincible.
