Objective:Cancer-associated inflammation and coagulation cascades play vital roles in cancer progression and survival.In this study,we investigated the significance of the combination of preoperative fibrinogen and th...Objective:Cancer-associated inflammation and coagulation cascades play vital roles in cancer progression and survival.In this study,we investigated the significance of the combination of preoperative fibrinogen and the neutrophil-to-lymphocyte ratio(NLR)in predicting the survival of patients with non-small cell lung cancer(NSCLC).Methods:We retrospectively enrolled 589 patients with NSCLC who underwent surgery.The univariate and multivariate Cox survival analyses were used to evaluate the prognostic indicators,including the combination of fibrinogen and NLR(F-NLR).The cut-off values for fibrinogen,NLR,and clinical laboratory variables were defined by the receiver operating characteristic(ROC)curve analysis.According to the ROC curve,the recommended cut-off values for fibrinogen and the NLR were 3.48 g/L and 2.30,respectively.Patients with both a high NLR(≥2.30)and hyperfibrinogenemia(≥3.48 g/L)were given a score of 2,whereas those with one or neither were scored as 1 or 0,respectively.Results:Our results showed that F-NLR was an independent prognostic indicator for disease-free survival(DFS)[hazard ratio(HR),1.466;95%confidence interval(CI),1.243–1.730;P<0.001]and overall survival(OS)(HR,1.512;95%CI,1.283–1.783;P<0.001).The five-year OS rates were 66.1%,53.5%,and 33.3%for the F-NLR=0,F-NLR=1,and F-NLR=2,respectively(P<0.001).Correspondingly,their five-year DFS rates were 62.2%,50.3%,and 30.4%,respectively(P<0.001).In the subgroup analyses of the pathological stages,the F-NLR level was significantly correlated with DFS and OS in stage I and IIIA cancers.Conclusions:Preoperative F-NLR score can be used as a valuable prognostic marker for patients with resectable early-stage NSCLC.展开更多
By creating a labor market dynamic general equilibrium model, this paper derives the pass-through mechanism of exchange rate's employment and wage effects,carries out an empirical study on the employment and wage ...By creating a labor market dynamic general equilibrium model, this paper derives the pass-through mechanism of exchange rate's employment and wage effects,carries out an empirical study on the employment and wage effects of RMB exchange rate for manufacturing sectors in China and the United States based on ridge regression, and examines the role of industry characteristics in this process. Research findings suggest that: RMB depreciation will drive employment and wage growth for most of China's laborintensive manufacturing sectors, and RMB appreciation will increase employment for certain capital-and technology-intensive sectors; but RMB depreciation has insignificant employment and wage effects for most sectors in the US. Hence, in achieving the longterm stability of RMB exchange rate, China should take advantage of RMB appreciation's manufacturing upgrade effect and ensure the steady growth of manufacturing employment.The US should make breakthroughs in various links of its economic development in order to tackle unemployment, instead of blaming RMB exchange rate. In addition, the nature of business activities and trade union characteristic are both significant factors that lead to differences in inter-sector employment levels of Chinese and US manufacturing sectors.Technology characteristic and other monopolistic characteristics exert decisive effects on the difference of wage return for various sectors in China and the US.展开更多
OBJECTIVE To analyze clinical characteristics and treatment methods of the patients with adenocarcinoma of the uterine cervix （AUC） and adenosquamous carcinoma of the cervix （ASCC）. To compare the survival time of...OBJECTIVE To analyze clinical characteristics and treatment methods of the patients with adenocarcinoma of the uterine cervix （AUC） and adenosquamous carcinoma of the cervix （ASCC）. To compare the survival time of the patients in 2 groups and analyze the prognostic factors. METHODS Clinical data of both 123 patients with AUC and 32 patients with ASCC treated at the Cancer Hospital, Chinese Academy of Medical Science （CAMS） ＆ Peking Union Medical College （PUMC）, were retrospectively analyzed. RESULTS The median age of the AUC patients was 50 years, and that of the ASCC patients was 44, P = 0.019. Poorly-differentiated （grade 3） cases accounted for 59.5% of the total ASCC patients, while only 32.5% of the AUC patients were in grade 3, P = 0.002. In 123 AUC patients, relapse or failure of the treatment occurred in 63 of the patients （51.2%）, and the median relapse time was 6 months （0-59 months）. In 32 ASCC patients, relapse or failure of the treatment occurred in 8 of these patients （51.2%）, with a median relapse time of 4.5 months （0-52 months）. The overall 5-year survival rate of the AUC patients was 49.8%, which was significantly lower than that of the ASCC patients （74.1%）, P = 0.015. The 5-year survival rates of the ASCC patients in Stage Ⅰ-Ⅲ were higher than that of the AUC patients with the same stages. However, statistical significant difference could only be found among the patients in Stage II, P = 0.006. The 5-year survival rates of the ASCC patients with various differential grade were higher than those of the AUC patients with the same differential grade, but statistical significant difference could only be found among the patients in the two groups with moderately differentiation, P = 0.039. It was found by Cox regression analysis that only clinical stage （P 〈 0.001） and histological type （P = 0.046） were the independent prognostic factors. CONCLUSION Clinical stage and histological type were the independent prognostic factors of the AUC and ASCC patients. The prOgnosis of ASCC patients is better than that of the AUC patients.展开更多
For earthquake and tsunami early warning and emergency response,the earthquake epicenter and magnitude should be determined rapidly and correctly.Using high-rate GPS observations,we can readily obtain precise and high...For earthquake and tsunami early warning and emergency response,the earthquake epicenter and magnitude should be determined rapidly and correctly.Using high-rate GPS observations,we can readily obtain precise and high resolution displacement time series and the seismic waveforms during the earthquake.In this paper,a new algorithm is proposed for estimating the earthquake epicenter and magnitude with the seismic waveforms derived from high-rate GPS data during the earthquake.A case study of the 2008 Wenchuan earthquake is conducted from 1 Hz GPS data and the epicenter and magnitude are determined.Compared with the results issued by the China Seismological Bureau,the estimation error of the epicenter and the magnitude is about 12 km and 0.1 magnitude unit,respectively.It has shown that high-rate GPS could be a new tool feasible for estimating the earthquake epicenter and magnitude,independent of or combined with seismometers.展开更多
基金supported by grants from National Key R&D Program of China (Grant No. 2016YFC0905501)the Tianjin Science and Technology Major Project, China (Grant No. 12ZCDZSY15400)
文摘Objective:Cancer-associated inflammation and coagulation cascades play vital roles in cancer progression and survival.In this study,we investigated the significance of the combination of preoperative fibrinogen and the neutrophil-to-lymphocyte ratio(NLR)in predicting the survival of patients with non-small cell lung cancer(NSCLC).Methods:We retrospectively enrolled 589 patients with NSCLC who underwent surgery.The univariate and multivariate Cox survival analyses were used to evaluate the prognostic indicators,including the combination of fibrinogen and NLR(F-NLR).The cut-off values for fibrinogen,NLR,and clinical laboratory variables were defined by the receiver operating characteristic(ROC)curve analysis.According to the ROC curve,the recommended cut-off values for fibrinogen and the NLR were 3.48 g/L and 2.30,respectively.Patients with both a high NLR(≥2.30)and hyperfibrinogenemia(≥3.48 g/L)were given a score of 2,whereas those with one or neither were scored as 1 or 0,respectively.Results:Our results showed that F-NLR was an independent prognostic indicator for disease-free survival(DFS)[hazard ratio(HR),1.466;95%confidence interval(CI),1.243–1.730;P<0.001]and overall survival(OS)(HR,1.512;95%CI,1.283–1.783;P<0.001).The five-year OS rates were 66.1%,53.5%,and 33.3%for the F-NLR=0,F-NLR=1,and F-NLR=2,respectively(P<0.001).Correspondingly,their five-year DFS rates were 62.2%,50.3%,and 30.4%,respectively(P<0.001).In the subgroup analyses of the pathological stages,the F-NLR level was significantly correlated with DFS and OS in stage I and IIIA cancers.Conclusions:Preoperative F-NLR score can be used as a valuable prognostic marker for patients with resectable early-stage NSCLC.
文摘By creating a labor market dynamic general equilibrium model, this paper derives the pass-through mechanism of exchange rate's employment and wage effects,carries out an empirical study on the employment and wage effects of RMB exchange rate for manufacturing sectors in China and the United States based on ridge regression, and examines the role of industry characteristics in this process. Research findings suggest that: RMB depreciation will drive employment and wage growth for most of China's laborintensive manufacturing sectors, and RMB appreciation will increase employment for certain capital-and technology-intensive sectors; but RMB depreciation has insignificant employment and wage effects for most sectors in the US. Hence, in achieving the longterm stability of RMB exchange rate, China should take advantage of RMB appreciation's manufacturing upgrade effect and ensure the steady growth of manufacturing employment.The US should make breakthroughs in various links of its economic development in order to tackle unemployment, instead of blaming RMB exchange rate. In addition, the nature of business activities and trade union characteristic are both significant factors that lead to differences in inter-sector employment levels of Chinese and US manufacturing sectors.Technology characteristic and other monopolistic characteristics exert decisive effects on the difference of wage return for various sectors in China and the US.
文摘OBJECTIVE To analyze clinical characteristics and treatment methods of the patients with adenocarcinoma of the uterine cervix （AUC） and adenosquamous carcinoma of the cervix （ASCC）. To compare the survival time of the patients in 2 groups and analyze the prognostic factors. METHODS Clinical data of both 123 patients with AUC and 32 patients with ASCC treated at the Cancer Hospital, Chinese Academy of Medical Science （CAMS） ＆ Peking Union Medical College （PUMC）, were retrospectively analyzed. RESULTS The median age of the AUC patients was 50 years, and that of the ASCC patients was 44, P = 0.019. Poorly-differentiated （grade 3） cases accounted for 59.5% of the total ASCC patients, while only 32.5% of the AUC patients were in grade 3, P = 0.002. In 123 AUC patients, relapse or failure of the treatment occurred in 63 of the patients （51.2%）, and the median relapse time was 6 months （0-59 months）. In 32 ASCC patients, relapse or failure of the treatment occurred in 8 of these patients （51.2%）, with a median relapse time of 4.5 months （0-52 months）. The overall 5-year survival rate of the AUC patients was 49.8%, which was significantly lower than that of the ASCC patients （74.1%）, P = 0.015. The 5-year survival rates of the ASCC patients in Stage Ⅰ-Ⅲ were higher than that of the AUC patients with the same stages. However, statistical significant difference could only be found among the patients in Stage II, P = 0.006. The 5-year survival rates of the ASCC patients with various differential grade were higher than those of the AUC patients with the same differential grade, but statistical significant difference could only be found among the patients in the two groups with moderately differentiation, P = 0.039. It was found by Cox regression analysis that only clinical stage （P 〈 0.001） and histological type （P = 0.046） were the independent prognostic factors. CONCLUSION Clinical stage and histological type were the independent prognostic factors of the AUC and ASCC patients. The prOgnosis of ASCC patients is better than that of the AUC patients.
基金supported by the National Natural Science Foundation of China (Grant Nos. 41104024, 41231174 & 41274049)
文摘For earthquake and tsunami early warning and emergency response,the earthquake epicenter and magnitude should be determined rapidly and correctly.Using high-rate GPS observations,we can readily obtain precise and high resolution displacement time series and the seismic waveforms during the earthquake.In this paper,a new algorithm is proposed for estimating the earthquake epicenter and magnitude with the seismic waveforms derived from high-rate GPS data during the earthquake.A case study of the 2008 Wenchuan earthquake is conducted from 1 Hz GPS data and the epicenter and magnitude are determined.Compared with the results issued by the China Seismological Bureau,the estimation error of the epicenter and the magnitude is about 12 km and 0.1 magnitude unit,respectively.It has shown that high-rate GPS could be a new tool feasible for estimating the earthquake epicenter and magnitude,independent of or combined with seismometers.
