AIM:To identify the risk factors and three single nucleotide polymorphisms(SNPs) of NOD2/CARD15 gene in inflammatory bowel disease(IBD) of the population in Zhejiang,China.METHODS:A case-control study was conducted us...AIM:To identify the risk factors and three single nucleotide polymorphisms(SNPs) of NOD2/CARD15 gene in inflammatory bowel disease(IBD) of the population in Zhejiang,China.METHODS:A case-control study was conducted using recall questionnaire to collect data on demographic,socioeconomic,lifestyle characteristics and dietary behaviors from 136 determined IBD patients and 136 paired healthy controls.COX regression method was used to screen the statistically significant risk factors for IBD.The polymorphisms of NOD2/CARD15 gene Arg702Trp,Gly908Arg and Leu1007fsinsC were genotyped and further compared between 60 patients with IBD and 60 healthy controls by polymerase chain reaction and restriction fragment length polymorphism.RESULTS:IBD occurred primarily in young and middle-aged people.The mean age for IBD patients was 42.6 years.The ratio of males to females was 1.23:1.COX regression indicated a higher statistical significance in milk,fried food and stress compared with the other postulated risk factors for IBD.None of the patients with IBD and healthy controls had heterozygous or homozygous SNPs variants.CONCLUSION:Milk,fried food and stress are associated with increased risk of IBD.The common variants in NOD2/CARD15 gene are not associated with IBD in China's Zhejiang population.展开更多
China is currently experiencing one of the most rapidly expanding HIV epidemics in the world. Although the overall prevalence rate is still low, with a population of 1.3 billion, high-risk factors which have contribut...China is currently experiencing one of the most rapidly expanding HIV epidemics in the world. Although the overall prevalence rate is still low, with a population of 1.3 billion, high-risk factors which have contributed to the HIV/AIDS epidemics worldwide continue to prevail in China, including a high rate of injecting drug use and needle sharing, commercial sex with low rates of condom use, and concurrent sex with both commercial sex workers and noncommercial casual or steady sex partners. In addition, there are increasing “double risk” populations overlapping drug users and sex workers, as well as increasing rates of STDs and HIV among high-risk populations. Sexual transmission, therefore, may serve as a bridge connecting high-risk populations with general populations. There is an urgent need to prevent the spread of HIV from these high-risk oooulations into the general oooulation of China.展开更多
The objective of social development is to construct a harmonious society.In China,the key to a harmonious society is the happiness of more than 900 million farmers living in the rural areas.This study aimed to measure...The objective of social development is to construct a harmonious society.In China,the key to a harmonious society is the happiness of more than 900 million farmers living in the rural areas.This study aimed to measure rural residents' subjective well-being(SWB) through the day reconstruction method,as well as to analyze SWB's influencing factors through a variety of statistical methods.The results showed that the average U index was 12.79%,indicating that respondents were unhappy 12.79% of the time.Twenty-seven percent of the population had a U index greater than 0,with the average value being 47%,indicating that these people were unhappy 47% of the time.The study also found that SWB varied according to the characteristics of the respondents.Logistic regression analysis showed that social and demographic factors,including age,education,county,household size,generation number,per capita income,migration status and social networking,which significantly affected rural residents' SWB.The size of the impact varied with the different factors.展开更多
At present, the aging situation of China's population is becoming more and more serious. By the end of 2016, there were 231 million people over the age of 60 in China, accounting for 16.7% of the total population. Ab...At present, the aging situation of China's population is becoming more and more serious. By the end of 2016, there were 231 million people over the age of 60 in China, accounting for 16.7% of the total population. About 150 million people aged 65 and over make up 10.8 percent of the total population. China is expected to enter the peak period of population aging by 2035. Therefore, the government as a single pension service main body management pattern already can not adapt to our country entered the aging society, mobilize and fostering social organizations to participate in the pension services is to build perfect endowment service system, satisfy people pension service demand model of a kind of indispensable. In view of the development of social organizations has just started in our country, there exist many problems and difficulties, so this article USES the ISM method, for social organizations to participate in research and analyze influence factors of pension services, and then find out the social organization in the process of participation in pension service problems, put forward effective solutions.展开更多
Existing evidence on the relationship between cardiovascular health(CVH) metrics and cardiovascular disease(CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics o...Existing evidence on the relationship between cardiovascular health(CVH) metrics and cardiovascular disease(CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics on preventing incident atherosclerotic CVD(ASCVD) in Chinese population. This study was conducted among 93,987 adults from the China-PAR project(Prediction for ASCVD Risk in China) who were followed up until 2015. Cox proportional hazard regression models were used to estimate the hazard ratios(HRs) and their corresponding 95% confidence intervals(CIs) of CVH metrics for the risk of ASCVD, including coronary heart disease(CHD), stroke and ASCVD death. We further estimated the population-attributable risk percentage(PAR%) of these metrics in relation to each outcome. We observed gradient inverse associations between the number of ideal CVH metrics and ASCVD incidence. Compared with participants having ≤2 ideal CVH metrics, the multivariable-adjusted HRs(95% CIs) of ASCVD for those with 3, 4, 5, 6 and 7 ideal CVH metrics were 0.83(0.74–0.93), 0.66(0.59–0.74), 0.55(0.48–0.61), 0.44(0.38–0.50) and 0.24(0.18–0.31), respectively(P for trend <0.0001). Approximately 62.1% of total ASCVD, 38.7% of CHD, 66.4% of stroke, and 60.5% of ASCVD death were attributable to not achieving all the seven ideal CVH metrics. After adjusting effects of ideal health factors, having four ideal health behaviors could independently bring adults health benefits in preventing 17.4% of ASCVD, 18.0% of CHD, 16.7% of stroke, and 10.1% of ASCVD death. Among all the seven CVH metrics, to keep with ideal blood pressure(BP) implied the largest public health gains against various ASCVD events(PAR% between 33.0% and 47.2%), while ideal diet was the metric most difficult to be achieved in the long term. Our study indicates that the more ideal CVH metrics adults have, the less ASCVD burden there is in China. Special efforts of health education and behavior modification should be made on keeping ideal BP and dietary habits in general Chinese population to prevent the epidemic of ASCVD.展开更多
文摘AIM:To identify the risk factors and three single nucleotide polymorphisms(SNPs) of NOD2/CARD15 gene in inflammatory bowel disease(IBD) of the population in Zhejiang,China.METHODS:A case-control study was conducted using recall questionnaire to collect data on demographic,socioeconomic,lifestyle characteristics and dietary behaviors from 136 determined IBD patients and 136 paired healthy controls.COX regression method was used to screen the statistically significant risk factors for IBD.The polymorphisms of NOD2/CARD15 gene Arg702Trp,Gly908Arg and Leu1007fsinsC were genotyped and further compared between 60 patients with IBD and 60 healthy controls by polymerase chain reaction and restriction fragment length polymorphism.RESULTS:IBD occurred primarily in young and middle-aged people.The mean age for IBD patients was 42.6 years.The ratio of males to females was 1.23:1.COX regression indicated a higher statistical significance in milk,fried food and stress compared with the other postulated risk factors for IBD.None of the patients with IBD and healthy controls had heterozygous or homozygous SNPs variants.CONCLUSION:Milk,fried food and stress are associated with increased risk of IBD.The common variants in NOD2/CARD15 gene are not associated with IBD in China's Zhejiang population.
文摘China is currently experiencing one of the most rapidly expanding HIV epidemics in the world. Although the overall prevalence rate is still low, with a population of 1.3 billion, high-risk factors which have contributed to the HIV/AIDS epidemics worldwide continue to prevail in China, including a high rate of injecting drug use and needle sharing, commercial sex with low rates of condom use, and concurrent sex with both commercial sex workers and noncommercial casual or steady sex partners. In addition, there are increasing “double risk” populations overlapping drug users and sex workers, as well as increasing rates of STDs and HIV among high-risk populations. Sexual transmission, therefore, may serve as a bridge connecting high-risk populations with general populations. There is an urgent need to prevent the spread of HIV from these high-risk oooulations into the general oooulation of China.
基金supported by Independent Inovation Foundation of Shandong Univercity,IIFSDU
文摘The objective of social development is to construct a harmonious society.In China,the key to a harmonious society is the happiness of more than 900 million farmers living in the rural areas.This study aimed to measure rural residents' subjective well-being(SWB) through the day reconstruction method,as well as to analyze SWB's influencing factors through a variety of statistical methods.The results showed that the average U index was 12.79%,indicating that respondents were unhappy 12.79% of the time.Twenty-seven percent of the population had a U index greater than 0,with the average value being 47%,indicating that these people were unhappy 47% of the time.The study also found that SWB varied according to the characteristics of the respondents.Logistic regression analysis showed that social and demographic factors,including age,education,county,household size,generation number,per capita income,migration status and social networking,which significantly affected rural residents' SWB.The size of the impact varied with the different factors.
文摘At present, the aging situation of China's population is becoming more and more serious. By the end of 2016, there were 231 million people over the age of 60 in China, accounting for 16.7% of the total population. About 150 million people aged 65 and over make up 10.8 percent of the total population. China is expected to enter the peak period of population aging by 2035. Therefore, the government as a single pension service main body management pattern already can not adapt to our country entered the aging society, mobilize and fostering social organizations to participate in the pension services is to build perfect endowment service system, satisfy people pension service demand model of a kind of indispensable. In view of the development of social organizations has just started in our country, there exist many problems and difficulties, so this article USES the ISM method, for social organizations to participate in research and analyze influence factors of pension services, and then find out the social organization in the process of participation in pension service problems, put forward effective solutions.
基金supported by grants from the CAMS Innovation Fund for Medical Sciences (2017-12M-1-004)Ministry of Science and Technology of China (2017YFC0211700)National Natural Science Foundation of China (91643208)
文摘Existing evidence on the relationship between cardiovascular health(CVH) metrics and cardiovascular disease(CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics on preventing incident atherosclerotic CVD(ASCVD) in Chinese population. This study was conducted among 93,987 adults from the China-PAR project(Prediction for ASCVD Risk in China) who were followed up until 2015. Cox proportional hazard regression models were used to estimate the hazard ratios(HRs) and their corresponding 95% confidence intervals(CIs) of CVH metrics for the risk of ASCVD, including coronary heart disease(CHD), stroke and ASCVD death. We further estimated the population-attributable risk percentage(PAR%) of these metrics in relation to each outcome. We observed gradient inverse associations between the number of ideal CVH metrics and ASCVD incidence. Compared with participants having ≤2 ideal CVH metrics, the multivariable-adjusted HRs(95% CIs) of ASCVD for those with 3, 4, 5, 6 and 7 ideal CVH metrics were 0.83(0.74–0.93), 0.66(0.59–0.74), 0.55(0.48–0.61), 0.44(0.38–0.50) and 0.24(0.18–0.31), respectively(P for trend <0.0001). Approximately 62.1% of total ASCVD, 38.7% of CHD, 66.4% of stroke, and 60.5% of ASCVD death were attributable to not achieving all the seven ideal CVH metrics. After adjusting effects of ideal health factors, having four ideal health behaviors could independently bring adults health benefits in preventing 17.4% of ASCVD, 18.0% of CHD, 16.7% of stroke, and 10.1% of ASCVD death. Among all the seven CVH metrics, to keep with ideal blood pressure(BP) implied the largest public health gains against various ASCVD events(PAR% between 33.0% and 47.2%), while ideal diet was the metric most difficult to be achieved in the long term. Our study indicates that the more ideal CVH metrics adults have, the less ASCVD burden there is in China. Special efforts of health education and behavior modification should be made on keeping ideal BP and dietary habits in general Chinese population to prevent the epidemic of ASCVD.