为系统、深入地研究中国西部盆(盆地)、山(山脉)、原(高原)的壳幔结构与深部动力学过程,2003年我们提出并领导实施了“羚羊计划”(ANTILOPE-Array Network of Tibetan International Lithospheric Observation and Probe Experiments),...为系统、深入地研究中国西部盆(盆地)、山(山脉)、原(高原)的壳幔结构与深部动力学过程,2003年我们提出并领导实施了“羚羊计划”(ANTILOPE-Array Network of Tibetan International Lithospheric Observation and Probe Experiments),在青藏高原先后完成了羚羊-I(ANTILOPE-I)到羚羊-IV(ANTILOPE-IV)4条二维宽频带台阵剖面,而在青藏高原东西构造结则实施了羚羊-V和羚羊-VI两个三维宽频带台阵探测。另外,我们将前期在准噶尔盆地、天山造山带、塔里木盆地、阿尔金造山带和柴达木盆地开展的九条综合地球物理观测剖面也纳入羚羊计划的总体框架中来。通过“羚羊计划”的实施,我们在中国西部(包括西北部的环青藏高原盆山体系以及西南部的青藏高原)取得了大量的、高质量的、综合的第一手观测数据,获得了中国西部盆、山、原精细的壳幔结构,系统地揭示了中国西部盆山原的深部地球动力学过程。主要结论总结如下:确定了准噶尔盆地基底的结构与属性,优化了盆地的基底构造格架;建立了天山造山带“层间插入削减”新的陆内造山模式,揭示了印欧碰撞在天山岩石圈缩短44%的去向以及由洋陆俯冲到陆陆碰撞俯冲的转换机制;揭示了塔里木盆地、阿尔金造山带和柴达木盆地的盆山接触关系;获得了塔里木盆地顺时针旋转的深部几何学、运动学和动力学证据;确定了青藏高原之下印度板块与欧亚板块的碰撞边界;发现目前的青藏高原由南部的印度板块、北部的欧亚板块和夹持于二者之间的巨型破碎区——西藏“板块”构成,首次确定了各自的岩石圈底边界;修正了高原变形的两个端员模型;建立了深部构造对地表地形的制约关系;系统地揭示了印度板块沿喜马拉雅造山带俯冲的水平距离与俯冲角度的变化规律与控制因素。“羚羊计划”以其巨大的观测网络与综合地球物理探测技术,采用地球物理学、地质学、地球化学等不同学科相结合的分析方法,揭示了印度板块俯冲、西藏巨型破碎区发育、塔里木板块顺时针旋转、西部水汽通道提前关闭、中国西北部干旱、沙漠化提前这一深部结构、动力学过程及其对地表地形、油气资源和环境变化的制约关系,推动了青藏高原地球系统科学理论的发展。展开更多
目的通过体内实验研究婴儿双歧杆菌(Bifidobacterium infantis 13.085)和雷帕霉素对中国对虾原肌球蛋白致敏BALB/c小鼠过敏反应的治疗作用,从Treg/Th17细胞平衡及相关细胞因子角度探讨其缓解过敏的免疫调节作用机制。方法将中国对虾原...目的通过体内实验研究婴儿双歧杆菌(Bifidobacterium infantis 13.085)和雷帕霉素对中国对虾原肌球蛋白致敏BALB/c小鼠过敏反应的治疗作用,从Treg/Th17细胞平衡及相关细胞因子角度探讨其缓解过敏的免疫调节作用机制。方法将中国对虾原肌球蛋白和弗氏佐剂混合液腹腔注射诱发BALB/c小鼠致敏,建立动物过敏模型。将实验小鼠随机分为正常对照组、致敏对照组、双歧杆菌治疗组、雷帕霉素治疗组。观察分析小鼠过敏症状,采用ELISA测定小鼠血清中特异性IgE、IgG2a的含量,采用流式细胞术测定脾脏T淋巴细胞亚群(Treg、Th17)数量,采用荧光定量PCR测定脾脏中Treg型和Th17型细胞因子和转录因子的表达量。结果第56天实验周期结束后结果发现,相比于致敏对照组,双歧杆菌和雷帕霉素治疗组小鼠过敏症状有明显的缓解,血清中特异性IgE显著降低(P<0.05),脾脏Treg/Th17比值显著升高(P<0.05),Th17型细胞因子IL-17A m RNA表达水平显著降低,Treg型细胞因子Foxp3 m RNA表达水平显著升高。此外,不同剂量的雷帕霉素治疗组缓解过敏反应存在剂量差异性。结论双歧杆菌13.085和雷帕霉素能有效缓解小鼠过敏症状,其作用可能通过平衡Treg/Th17细胞亚群数量,促进Treg型细胞因子表达而抑制Th17型细胞因子分泌有关。展开更多
Sandy forest-steppe ecotone in Baiyinaobao Natural Reserve of Inner Mongolia Autonomous Region of China is one of the special landscape types in forest-steppe vegetation zone in China. Vegetation landscape types, land...Sandy forest-steppe ecotone in Baiyinaobao Natural Reserve of Inner Mongolia Autonomous Region of China is one of the special landscape types in forest-steppe vegetation zone in China. Vegetation landscape types, landscape patches, and patch size were measured by the field investigation, forest photograph, and airscape. The structure of landscape patches in sandy forest-steppe ecotone, including composition structure, and size structure, was studied and the dynamics and transformation of landscape patches were analyzed. The data obtained in this study could provide theoretical basis for the research on vegetation landscape in forest-steppe ecotones and other vegetation types.展开更多
A field experiment was conducted to investigate the fate of ^15N-labeled urea and its residual effect under the winter wheat (Triticum aestivum L.) and summer maize (Zea mays L.) rotation system on the North China...A field experiment was conducted to investigate the fate of ^15N-labeled urea and its residual effect under the winter wheat (Triticum aestivum L.) and summer maize (Zea mays L.) rotation system on the North China Plain. Compared to a conventional application rate of 360 kg N ha^-1 (N360), a reduced rate of 120 kg N ha^-1 (N120) led to a significant increase (P 〈 0.05) in wheat yield and no significant differences were found for maize. However, in the 0-100 cm soil profile at harvest, compared with N360, N120 led to significant decreases (P 〈 0.05) of percent residual N and percent unaccounted-for N, which possibly reflected losses from the managed system. Of the residual fertilizer N in the soil profile, 25.6%-44.7% and 20.7%-38.2% for N120 and N360, respectively, were in the organic N pool, whereas 0.3%-3.0% and 11.2%-24.4%, correspondingly, were in the nitrate pool, indicating a higher potential for leaching loss associated with application at the conventional rate. Recovery of residual N in the soil profile by succeeding crops was less than 7.5% of the applied N. For N120, total soil N balance was negative; however, there was still considerable mineral N (NH4^+-N and NO3^--N) in the soil profile after harvest. Therefore, N120 could be considered ngronomically acceptable in the short run, but for long-term sustainability, the N rate should be recommended based on a soil mineral N test and a plant tissue nitrate test to maintain the soil fertility.展开更多
Maize (Zea mays L.), a staple crop grown from June to September during the rainy season on the North China Plain,is usually inter-planted in winter wheat (Triticum aestivum L.) fields about one week before harvesting ...Maize (Zea mays L.), a staple crop grown from June to September during the rainy season on the North China Plain,is usually inter-planted in winter wheat (Triticum aestivum L.) fields about one week before harvesting of the winterwheat. In order to improve irrigation efficiency in this region of serious water shortage, field studies in 1999 and 2001, twodry seasons with less than average seasonal rainfall, were conducted with up to five irrigation applications to determineevapotranspiration, calculate the crop coefficient, and optimize the irrigation schedule with maize under mulch, as well asto establish the effects of irrigation timing and the number of applications on grain yield and water use efficiency (WUE)of maize. Results showed that with grain production at about 8 000 kg ha-1 the total evapotranspiration and WUE ofirrigated maize under mulch were about 380-400 mm and 2.0-2.2 kg m-3, respectively. Also in 2001 WUE of maizewith mulch for the treatment with three irrigations was 11.8% better than that without mulch. In the 1999 and 2001seasons, maize yield significantly improved (P = 0.05) with four irrigation applications, however, further increases werenot significant. At the same time there were no significant differences for WUE with two to four irrigation applications.In the 2001 season mulch lead to a decrease of 50 mm in the total soil evaporation, and the maize crop coefficient undermulch varied between 0.3-1.3 with a seasonal average of 1.0.展开更多
Coal and shale are both unconventional gas reservoirs. Comparison of pore characteristics in shale and coal would help understand organic pore structure in shale and investigate co-exploration of shale gas and coalbed...Coal and shale are both unconventional gas reservoirs. Comparison of pore characteristics in shale and coal would help understand organic pore structure in shale and investigate co-exploration of shale gas and coalbed methane in coal bearing strata. In this study, five shale samples and three coal samples of Taiyuan Formation were collected from Qinshui Basin, China. High pressure mercury injection, scanning electronic microscopy, and fractal theory have been used to compare pore characteristics in shale and coal. The results show that pore volumes in coal are much larger than that in shale, especially pores 3-100 nm. In coal, there are many semi-closed pores in micro pores (〈10 nm) and transition pores (10-100 nm). On the contrary, micro pores and transition pores are mainly with open pores in shale. The fractal curves show that pores larger than 65 nm in coal and shale reservoir both have obvious self-similarity and the fractal dimension values in shale and coal are similar. But the fractal characteristics of pores smaller than 65 nm in shale reservoir are quite different from that in coal.展开更多
Objective To evaluate the sensitivity and specificity of international classification criteria (2002) for primary Sjogren's syndrome (pSS) and the role of lower lip biopsy in diagnosis of pSS in Chinese patients....Objective To evaluate the sensitivity and specificity of international classification criteria (2002) for primary Sjogren's syndrome (pSS) and the role of lower lip biopsy in diagnosis of pSS in Chinese patients. Mothoda Patients who were diagnosed by the experts/rheumatologists as pSS during 1990-2002 from the Department of Rheumatology, Peking Union Medical College Hospital were retrospectively collected as experimental group. Patients who were diagnosed as non-pSS connective tissue diseases or non-connective tissue diseases served as control group. Those with a history of head-neck radiation, hepatitis C virus infection, AIDS, lymphoma, sarcoidosis, graft versus host disease (GVHD), and anti-acetylcholine drug use were exempted. Both groups were required to complete questionnaires about symptoms such as dry eyes and dry mouth, and complete the objective tests of keratoconjunctivitis and xerostomia including Schirmer test, corneal staining, unstimulated salivary flow, sialography, lower lip biopsy, and antinuclear antibodies (including anti-SSA/SSB antibodies) test. Results A total of 330 pSS patients were included in experimental group and 185 non-pSS patients in control group. The mean age of both groups matched (47.8 ± 10.9 years vs. 46.2±13.6 years, P 〉 0.05). The sensitivities of the criteria in pSS patients with lower lip biopsy and in pSS patients without lower lip biopsy were 89.2% and 87.2%, respectively; the overall sensitivity was 88.5%. The specificity was 97.3%. A total of 11.3% pSS patients with negative anti-SSA/SSB antibodies were diagnosed as pSS by lower lip biopsy. Coadwion The international classification criteria (2002) for pSS is feasible in Chinese patients. It has high sensitivity and specificity, and may serve as diagnosis criteria in routine clinical practice.展开更多
The topographic maps of 1:50,000 scales,aerial photographs taken in 1966,one Landsat image taken in 1999,and SRTM data from 2000 were used to quantify the losses in area and volume of the glaciers on the Su-lo Mountai...The topographic maps of 1:50,000 scales,aerial photographs taken in 1966,one Landsat image taken in 1999,and SRTM data from 2000 were used to quantify the losses in area and volume of the glaciers on the Su-lo Mountain,in the northeastern Tibetan Plateau,China in the past 30 years.The total glacier area decreased from 492.9km2 in 1966 to 458.2km2 in 1999.The volume loss of the studied glaciers reached 1.4 km3 from 1966 to 2000.This agrees with documented changes in other mountain glaciers of the whole Tibetan Plateau.展开更多
Active host-pathogen interactions take place during infection of human immunodeficiency virus type 1 (HIV-1). Outcomes of these interactions determine the efficiency of viral infection and subsequent disease progressi...Active host-pathogen interactions take place during infection of human immunodeficiency virus type 1 (HIV-1). Outcomes of these interactions determine the efficiency of viral infection and subsequent disease progression. HIV- infected cells respond to viral invasion with various defensive strategies such as innate, cellular and humoral immune antiviral mechanisms. On the other hand, the virus has also developed various offensive tactics to suppress these host cellular responses. Among many of the viral offensive strategies, HIV-1 viral auxiliary proteins (Tat, Rev, Nef, Vif, Vpr and Vpu) play important roles in the host-pathogen interaction and thus have significant impacts on the outcome of HIV infection. One of the best examples is the interaction of Vif with a host cytidine deaminase APOBEC3G. Although specific roles of other auxiliary proteins are not as well described as Vif-APOBEC3G interaction, it is the goal of this brief review to summarize some of the preliminary findings with the hope to stimulate further discussion and investiga- tion in this exhilarating area of research.展开更多
Permafrost in China includes high latitude permafrost in northeastern China, alpine permafrost in northwestern China and high plateau permafrost on the Tibetan Plateau. The high altitude permafrost is about 92% of the...Permafrost in China includes high latitude permafrost in northeastern China, alpine permafrost in northwestern China and high plateau permafrost on the Tibetan Plateau. The high altitude permafrost is about 92% of the total permafrost area in China. The south boundary or lower limit of the seasonally frozen ground is defined in accordance with the 0 ℃ isothermal line of mean air temperature in January, which is roughly corresponding to the line extending from the Qinling Mountains to the Huaihe River in the east and to the southeast boundary of the Tibetan Plateau in the west. Seasonal frozen ground occurs in large parts of the territory in northern China, including Northeast, North, Northwest China and the Tibetan Plateau except for permafrost regions, and accounting for about 55% of the land area of China. The southern limit of short-term frozen ground generally swings south and north along the 25° northern latitude line, occurring in the wet and warm subtropic monsoon climatic zone. Its area is less than 20% of the land area of China.展开更多
The North China Plain,where summer corn(Zea mays L.)and winter wheat(Triticum aestivum L.)are the major crops grown,is a major agricultural area in China.Permeable soils make the region susceptible to groundwater poll...The North China Plain,where summer corn(Zea mays L.)and winter wheat(Triticum aestivum L.)are the major crops grown,is a major agricultural area in China.Permeable soils make the region susceptible to groundwater pollution by NO_3-N,which is applied to fields in large amounts of more than 400 kg NO_3-N ha^(-1)as fertilizer.A field experiment was established in 2002 to examine the relationship among N fertilization rate,soil NO_3-N,and NO_3-N groundwater contamination.Two adjacent fields were fertilized with local farmers' N fertilization rate(LN)and double the normal application rate(HN),respectively,and managed under otherwise identical conditions.The fields were under a traditional summer corn/winter wheat rotation.Over a 22-month period,we monitored NO_3-N concentrations in both bulk soil and soil pore water in 20-40 cm increments up to 180 cm depth.We also monitored NO_3-N concentrations in groundwater and the depth of the groundwater table.No significant differences in soil NO_3-N were observed between the LN and HN treatment.We identified NO_3-N plumes moving downward through the soil profile.The HN treatment resulted in significantly higher groundwater NO_3-N,relative to the LN treatment,with groundwater NO_3-N consistently exceeding the maximum safe level of 10 mg L^(-1),but groundwater NO_3-N above the maximum safe level was also observed in the LN treatment after heavy rain.Heavy rain in June,July,and August 2003 caused increased NO_3-N leaching through the soil and elevated NO_3-N concentrations in the groundwater.Concurrent rise of the groundwater table into NO_3-N- rich soil layers also contributed to the increased NO_3-N concentrations in the groundwater.Our results indicate that under conditions of average rainfall,soil NO_3-N was accumulated in the soil profile.The subsequent significantly higher- than-average rainfalls continuously flushed the soil NO_3-N into deeper layers and raised the groundwater table,which caused continuous groundwater contamination with NO_3-N.The results suggest that under common farming practices in the North China Plain,groundwater contamination with NO_3-N was likely,especially during heavy rainfalls,and the degree of groundwater contamination appeared to be proportional to the N application rates.Decreasing fertilization rates, splitting fertilizer inputs,and optimizing irrigation scheduling had potential to reduce groundwater NO_3-N contamination.展开更多
文摘为系统、深入地研究中国西部盆(盆地)、山(山脉)、原(高原)的壳幔结构与深部动力学过程,2003年我们提出并领导实施了“羚羊计划”(ANTILOPE-Array Network of Tibetan International Lithospheric Observation and Probe Experiments),在青藏高原先后完成了羚羊-I(ANTILOPE-I)到羚羊-IV(ANTILOPE-IV)4条二维宽频带台阵剖面,而在青藏高原东西构造结则实施了羚羊-V和羚羊-VI两个三维宽频带台阵探测。另外,我们将前期在准噶尔盆地、天山造山带、塔里木盆地、阿尔金造山带和柴达木盆地开展的九条综合地球物理观测剖面也纳入羚羊计划的总体框架中来。通过“羚羊计划”的实施,我们在中国西部(包括西北部的环青藏高原盆山体系以及西南部的青藏高原)取得了大量的、高质量的、综合的第一手观测数据,获得了中国西部盆、山、原精细的壳幔结构,系统地揭示了中国西部盆山原的深部地球动力学过程。主要结论总结如下:确定了准噶尔盆地基底的结构与属性,优化了盆地的基底构造格架;建立了天山造山带“层间插入削减”新的陆内造山模式,揭示了印欧碰撞在天山岩石圈缩短44%的去向以及由洋陆俯冲到陆陆碰撞俯冲的转换机制;揭示了塔里木盆地、阿尔金造山带和柴达木盆地的盆山接触关系;获得了塔里木盆地顺时针旋转的深部几何学、运动学和动力学证据;确定了青藏高原之下印度板块与欧亚板块的碰撞边界;发现目前的青藏高原由南部的印度板块、北部的欧亚板块和夹持于二者之间的巨型破碎区——西藏“板块”构成,首次确定了各自的岩石圈底边界;修正了高原变形的两个端员模型;建立了深部构造对地表地形的制约关系;系统地揭示了印度板块沿喜马拉雅造山带俯冲的水平距离与俯冲角度的变化规律与控制因素。“羚羊计划”以其巨大的观测网络与综合地球物理探测技术,采用地球物理学、地质学、地球化学等不同学科相结合的分析方法,揭示了印度板块俯冲、西藏巨型破碎区发育、塔里木板块顺时针旋转、西部水汽通道提前关闭、中国西北部干旱、沙漠化提前这一深部结构、动力学过程及其对地表地形、油气资源和环境变化的制约关系,推动了青藏高原地球系统科学理论的发展。
文摘目的通过体内实验研究婴儿双歧杆菌(Bifidobacterium infantis 13.085)和雷帕霉素对中国对虾原肌球蛋白致敏BALB/c小鼠过敏反应的治疗作用,从Treg/Th17细胞平衡及相关细胞因子角度探讨其缓解过敏的免疫调节作用机制。方法将中国对虾原肌球蛋白和弗氏佐剂混合液腹腔注射诱发BALB/c小鼠致敏,建立动物过敏模型。将实验小鼠随机分为正常对照组、致敏对照组、双歧杆菌治疗组、雷帕霉素治疗组。观察分析小鼠过敏症状,采用ELISA测定小鼠血清中特异性IgE、IgG2a的含量,采用流式细胞术测定脾脏T淋巴细胞亚群(Treg、Th17)数量,采用荧光定量PCR测定脾脏中Treg型和Th17型细胞因子和转录因子的表达量。结果第56天实验周期结束后结果发现,相比于致敏对照组,双歧杆菌和雷帕霉素治疗组小鼠过敏症状有明显的缓解,血清中特异性IgE显著降低(P<0.05),脾脏Treg/Th17比值显著升高(P<0.05),Th17型细胞因子IL-17A m RNA表达水平显著降低,Treg型细胞因子Foxp3 m RNA表达水平显著升高。此外,不同剂量的雷帕霉素治疗组缓解过敏反应存在剂量差异性。结论双歧杆菌13.085和雷帕霉素能有效缓解小鼠过敏症状,其作用可能通过平衡Treg/Th17细胞亚群数量,促进Treg型细胞因子表达而抑制Th17型细胞因子分泌有关。
基金The paper is supported by National Nature Science Foundation of China (grant numbers: 39900019, and 30070129).
文摘Sandy forest-steppe ecotone in Baiyinaobao Natural Reserve of Inner Mongolia Autonomous Region of China is one of the special landscape types in forest-steppe vegetation zone in China. Vegetation landscape types, landscape patches, and patch size were measured by the field investigation, forest photograph, and airscape. The structure of landscape patches in sandy forest-steppe ecotone, including composition structure, and size structure, was studied and the dynamics and transformation of landscape patches were analyzed. The data obtained in this study could provide theoretical basis for the research on vegetation landscape in forest-steppe ecotones and other vegetation types.
基金Project supported by the National Natural Science Foundation of China (Nos. 40571071, 30390080 and 30370287)the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT0511).
文摘A field experiment was conducted to investigate the fate of ^15N-labeled urea and its residual effect under the winter wheat (Triticum aestivum L.) and summer maize (Zea mays L.) rotation system on the North China Plain. Compared to a conventional application rate of 360 kg N ha^-1 (N360), a reduced rate of 120 kg N ha^-1 (N120) led to a significant increase (P 〈 0.05) in wheat yield and no significant differences were found for maize. However, in the 0-100 cm soil profile at harvest, compared with N360, N120 led to significant decreases (P 〈 0.05) of percent residual N and percent unaccounted-for N, which possibly reflected losses from the managed system. Of the residual fertilizer N in the soil profile, 25.6%-44.7% and 20.7%-38.2% for N120 and N360, respectively, were in the organic N pool, whereas 0.3%-3.0% and 11.2%-24.4%, correspondingly, were in the nitrate pool, indicating a higher potential for leaching loss associated with application at the conventional rate. Recovery of residual N in the soil profile by succeeding crops was less than 7.5% of the applied N. For N120, total soil N balance was negative; however, there was still considerable mineral N (NH4^+-N and NO3^--N) in the soil profile after harvest. Therefore, N120 could be considered ngronomically acceptable in the short run, but for long-term sustainability, the N rate should be recommended based on a soil mineral N test and a plant tissue nitrate test to maintain the soil fertility.
基金the Knowledge Innovation Project of the Chinese Academy of Sciences (No. KZCX-SW-317-02).
文摘Maize (Zea mays L.), a staple crop grown from June to September during the rainy season on the North China Plain,is usually inter-planted in winter wheat (Triticum aestivum L.) fields about one week before harvesting of the winterwheat. In order to improve irrigation efficiency in this region of serious water shortage, field studies in 1999 and 2001, twodry seasons with less than average seasonal rainfall, were conducted with up to five irrigation applications to determineevapotranspiration, calculate the crop coefficient, and optimize the irrigation schedule with maize under mulch, as well asto establish the effects of irrigation timing and the number of applications on grain yield and water use efficiency (WUE)of maize. Results showed that with grain production at about 8 000 kg ha-1 the total evapotranspiration and WUE ofirrigated maize under mulch were about 380-400 mm and 2.0-2.2 kg m-3, respectively. Also in 2001 WUE of maizewith mulch for the treatment with three irrigations was 11.8% better than that without mulch. In the 1999 and 2001seasons, maize yield significantly improved (P = 0.05) with four irrigation applications, however, further increases werenot significant. At the same time there were no significant differences for WUE with two to four irrigation applications.In the 2001 season mulch lead to a decrease of 50 mm in the total soil evaporation, and the maize crop coefficient undermulch varied between 0.3-1.3 with a seasonal average of 1.0.
基金The authors thank the National Science Foundation of China (41472135), the Research and Innovation Project for College Graduates of Jiangsu Province (KYLX15-1396), the Scientific Research Foundation of the Key Laboratory of Coalbed Methane Resources and Reservoir Formation Process, Ministry of Education (China University of Mining and Technology) (No. 2015-04) for the support of the research.
文摘Coal and shale are both unconventional gas reservoirs. Comparison of pore characteristics in shale and coal would help understand organic pore structure in shale and investigate co-exploration of shale gas and coalbed methane in coal bearing strata. In this study, five shale samples and three coal samples of Taiyuan Formation were collected from Qinshui Basin, China. High pressure mercury injection, scanning electronic microscopy, and fractal theory have been used to compare pore characteristics in shale and coal. The results show that pore volumes in coal are much larger than that in shale, especially pores 3-100 nm. In coal, there are many semi-closed pores in micro pores (〈10 nm) and transition pores (10-100 nm). On the contrary, micro pores and transition pores are mainly with open pores in shale. The fractal curves show that pores larger than 65 nm in coal and shale reservoir both have obvious self-similarity and the fractal dimension values in shale and coal are similar. But the fractal characteristics of pores smaller than 65 nm in shale reservoir are quite different from that in coal.
基金Supported by the National Natural Sciences Foundation of China(30300164 ).
文摘Objective To evaluate the sensitivity and specificity of international classification criteria (2002) for primary Sjogren's syndrome (pSS) and the role of lower lip biopsy in diagnosis of pSS in Chinese patients. Mothoda Patients who were diagnosed by the experts/rheumatologists as pSS during 1990-2002 from the Department of Rheumatology, Peking Union Medical College Hospital were retrospectively collected as experimental group. Patients who were diagnosed as non-pSS connective tissue diseases or non-connective tissue diseases served as control group. Those with a history of head-neck radiation, hepatitis C virus infection, AIDS, lymphoma, sarcoidosis, graft versus host disease (GVHD), and anti-acetylcholine drug use were exempted. Both groups were required to complete questionnaires about symptoms such as dry eyes and dry mouth, and complete the objective tests of keratoconjunctivitis and xerostomia including Schirmer test, corneal staining, unstimulated salivary flow, sialography, lower lip biopsy, and antinuclear antibodies (including anti-SSA/SSB antibodies) test. Results A total of 330 pSS patients were included in experimental group and 185 non-pSS patients in control group. The mean age of both groups matched (47.8 ± 10.9 years vs. 46.2±13.6 years, P 〉 0.05). The sensitivities of the criteria in pSS patients with lower lip biopsy and in pSS patients without lower lip biopsy were 89.2% and 87.2%, respectively; the overall sensitivity was 88.5%. The specificity was 97.3%. A total of 11.3% pSS patients with negative anti-SSA/SSB antibodies were diagnosed as pSS by lower lip biopsy. Coadwion The international classification criteria (2002) for pSS is feasible in Chinese patients. It has high sensitivity and specificity, and may serve as diagnosis criteria in routine clinical practice.
基金supported by the National Natural Science Foundation of China(40576001 and 40825017)the Chinese Academy of Sciences(KZCX3SW344 and 100 Talents Project)+1 种基金the Korean Research Council of Public Science and Technology(PP07010)the National Key Technology R&D Program(2006BAB18B01).
文摘The topographic maps of 1:50,000 scales,aerial photographs taken in 1966,one Landsat image taken in 1999,and SRTM data from 2000 were used to quantify the losses in area and volume of the glaciers on the Su-lo Mountain,in the northeastern Tibetan Plateau,China in the past 30 years.The total glacier area decreased from 492.9km2 in 1966 to 458.2km2 in 1999.The volume loss of the studied glaciers reached 1.4 km3 from 1966 to 2000.This agrees with documented changes in other mountain glaciers of the whole Tibetan Plateau.
文摘Active host-pathogen interactions take place during infection of human immunodeficiency virus type 1 (HIV-1). Outcomes of these interactions determine the efficiency of viral infection and subsequent disease progression. HIV- infected cells respond to viral invasion with various defensive strategies such as innate, cellular and humoral immune antiviral mechanisms. On the other hand, the virus has also developed various offensive tactics to suppress these host cellular responses. Among many of the viral offensive strategies, HIV-1 viral auxiliary proteins (Tat, Rev, Nef, Vif, Vpr and Vpu) play important roles in the host-pathogen interaction and thus have significant impacts on the outcome of HIV infection. One of the best examples is the interaction of Vif with a host cytidine deaminase APOBEC3G. Although specific roles of other auxiliary proteins are not as well described as Vif-APOBEC3G interaction, it is the goal of this brief review to summarize some of the preliminary findings with the hope to stimulate further discussion and investiga- tion in this exhilarating area of research.
文摘Permafrost in China includes high latitude permafrost in northeastern China, alpine permafrost in northwestern China and high plateau permafrost on the Tibetan Plateau. The high altitude permafrost is about 92% of the total permafrost area in China. The south boundary or lower limit of the seasonally frozen ground is defined in accordance with the 0 ℃ isothermal line of mean air temperature in January, which is roughly corresponding to the line extending from the Qinling Mountains to the Huaihe River in the east and to the southeast boundary of the Tibetan Plateau in the west. Seasonal frozen ground occurs in large parts of the territory in northern China, including Northeast, North, Northwest China and the Tibetan Plateau except for permafrost regions, and accounting for about 55% of the land area of China. The southern limit of short-term frozen ground generally swings south and north along the 25° northern latitude line, occurring in the wet and warm subtropic monsoon climatic zone. Its area is less than 20% of the land area of China.
基金Project supported by the Knowledge Innovation Program of the Chinese Academy of Sciences(No.kzc x2-yw-406)the National Basic Research Program of China(No.2005CB121103).
文摘The North China Plain,where summer corn(Zea mays L.)and winter wheat(Triticum aestivum L.)are the major crops grown,is a major agricultural area in China.Permeable soils make the region susceptible to groundwater pollution by NO_3-N,which is applied to fields in large amounts of more than 400 kg NO_3-N ha^(-1)as fertilizer.A field experiment was established in 2002 to examine the relationship among N fertilization rate,soil NO_3-N,and NO_3-N groundwater contamination.Two adjacent fields were fertilized with local farmers' N fertilization rate(LN)and double the normal application rate(HN),respectively,and managed under otherwise identical conditions.The fields were under a traditional summer corn/winter wheat rotation.Over a 22-month period,we monitored NO_3-N concentrations in both bulk soil and soil pore water in 20-40 cm increments up to 180 cm depth.We also monitored NO_3-N concentrations in groundwater and the depth of the groundwater table.No significant differences in soil NO_3-N were observed between the LN and HN treatment.We identified NO_3-N plumes moving downward through the soil profile.The HN treatment resulted in significantly higher groundwater NO_3-N,relative to the LN treatment,with groundwater NO_3-N consistently exceeding the maximum safe level of 10 mg L^(-1),but groundwater NO_3-N above the maximum safe level was also observed in the LN treatment after heavy rain.Heavy rain in June,July,and August 2003 caused increased NO_3-N leaching through the soil and elevated NO_3-N concentrations in the groundwater.Concurrent rise of the groundwater table into NO_3-N- rich soil layers also contributed to the increased NO_3-N concentrations in the groundwater.Our results indicate that under conditions of average rainfall,soil NO_3-N was accumulated in the soil profile.The subsequent significantly higher- than-average rainfalls continuously flushed the soil NO_3-N into deeper layers and raised the groundwater table,which caused continuous groundwater contamination with NO_3-N.The results suggest that under common farming practices in the North China Plain,groundwater contamination with NO_3-N was likely,especially during heavy rainfalls,and the degree of groundwater contamination appeared to be proportional to the N application rates.Decreasing fertilization rates, splitting fertilizer inputs,and optimizing irrigation scheduling had potential to reduce groundwater NO_3-N contamination.