AIM:To compare diverse endoscopic interventions in the management of occluded uncovered self-expanding metal stents(SEMSs) that had been placed for palliative treatment of unresectable malignant biliary obstruction.ME...AIM:To compare diverse endoscopic interventions in the management of occluded uncovered self-expanding metal stents(SEMSs) that had been placed for palliative treatment of unresectable malignant biliary obstruction.METHODS:A retrospective review was undertaken in 4 tertiary endoscopic centers to determine optimal management of different types of occluded SEMSs.The technical success of performed treatment in occluded SEMSs,the patency of the stent,the need for re-intervention and the financial costs of each treatment were analyzed.RESULTS:Fifty four patients were included in the analysis;21 received Hanaro,19 Wallstent and 14 Flexus.For the relief of obstruction,a plastic stent was inserted in 24 patients,a second SEMS in 25 and mechanical cleaning was performed in 5 patients.The overall median second patency rates between second SEMSs and plastic stents did not differ(133 d for SEMSs vs 106 d for plastic stents;P = 0.856).Similarly,no difference was found between the overall survival of SEMS and plastic stent groups,and no procedure-related complications occurred.Incremental cost analysis showed that successive plastic stenting was a cost-saving strategy at least in Greece.CONCLUSION:Insertion of uncovered SEMSs or plastic stents is a safe and effective treatment for occluded uncovered SEMSs;insertion of plastic stents appears to be the most cost-effective strategy.展开更多
The distribution of vertical stress for both active and passive state in the silo with a central innerdowncomer is reported in this paper. Experimental measurement of the axial distribution of vertical stress for both...The distribution of vertical stress for both active and passive state in the silo with a central innerdowncomer is reported in this paper. Experimental measurement of the axial distribution of vertical stress for bothactive and passive state in the silo are in good agreement with that predicted by theoretical analysis. The meanaxial stress is reduced due to the presence of the inner downcomer in the silo.展开更多
A supply chain is a network that performs the procurement of raw material, the transportation of raw material to intermediate and end products, and the distribution of end products to retailers or customers. Installat...A supply chain is a network that performs the procurement of raw material, the transportation of raw material to intermediate and end products, and the distribution of end products to retailers or customers. Installation and operation of distribution centers and all downstream members play a vital role in fulfilling the customers demand and have a great impact for supply chain management performance. In this paper we address a new approach for solving a supply chain optimization model to decide distribution centers based on environmental consideration.展开更多
Objective: To evaluate the effect of the treatment modality guided by intraventricular intracranial pressure (ICP) monitoring on patients with severe traumatic brain injury (TBI). Methods: The clinical data of ...Objective: To evaluate the effect of the treatment modality guided by intraventricular intracranial pressure (ICP) monitoring on patients with severe traumatic brain injury (TBI). Methods: The clinical data of a group of 136 severely brain-injured patients admitted to Shanghai Neurosurgical Emergency Center from December 2004 to February 2006 were studied. Results: The intraventricular ICP monitor was placed in all the 136 patients via Kocher's pathway, Paine's pathway or intraoperative opened ventricle. In this series, the probe was placed during the procedure of craniotomy in 98 patients; for other 38 patients, the probe was placed initially to measure or to monitor ICE A stepwise protocol targeting at ICP control (420 mm Hg) and optimal cerebral perfusion pressure (CPP) maintenance (60-90 mm Hg) was deployed.Among them, 76 patients survived with good recovery, 14 with moderate disability, 24 with severe disability, 10 with vegetative state, and 12 died. Complications associated with intraventricular ICP monitoring included hemorrhage and infection. Hemorrhage occurred in 1 patient and infection in 5 patients. There were no unacceptable complications related to ICP monitoring. Conclusions: Ventricular access for 1CP monitoring can be safely and accurately achieved. ICP monitoring via ventriculostomy may facilitate an early and accurate intervention for severely brain-injured patients. The intraventricular ICP monitoring is a low-risk procedure and can yield great benefits for management of patients with severe TBI.展开更多
Organic light-emitting diodes (OLEDs) have been extensively studied since the first efficient device based on small molecular luminescent materials was reported by Tang. Organic electroluminescent material, one of t...Organic light-emitting diodes (OLEDs) have been extensively studied since the first efficient device based on small molecular luminescent materials was reported by Tang. Organic electroluminescent material, one of the centerpieces of OLEDs, has been the focus of studies by many material scientists. To obtain high luminosity and to keep material costs low, a few remarkable design concepts have been developed. Aggregation-induced emission (AIE) materials were invented to overcome the common fluorescence-quenching problem, and cross-dipole stacking of fluorescent molecules was shown to be an effective method to get high solid-state luminescence. To exceed the limit of internal quantum efficiency of conventional fluorescent materials, phosphorescent materials were successfully applied in highly efficient electroluminescent devices. Most recently, delayed flu- orescent materials via reverse-intersystem crossing (RISC) from triplet to singlet and the "hot exciton" materials based on hy- bridized local and charge-transfer (HLCT) states were developed to he a new generation of low-cost luminescent materials as efficient as phosphorescent materials. In terms of the device-fabrication process, solution-processible small molecular lumi- nescent materials possess the advantages of high purity (vs. polymers) and low procession cost (vs. vacuum deposition), which are garnering them increasing attention. Herein, we review the progress of the development of small-molecule luminescent materials with different design concepts and features, and also briefly examine future development tendencies of luminescent materials.展开更多
Chalcogenide perovskites(CPs) exhibiting lower band gaps than oxide perovskites and higher stability than halide perovskites are promising materials for photovoltaic and optoelectronic applications. For such applicati...Chalcogenide perovskites(CPs) exhibiting lower band gaps than oxide perovskites and higher stability than halide perovskites are promising materials for photovoltaic and optoelectronic applications. For such applications, the absence of deep defect levels serving as recombination centers(dubbed defect tolerance) is a highly desirable property. Here,using density functional theory(DFT) calculations, we study the intrinsic defects in BaZrS_(3), a representative CP material.We compare Hubbard-U and hybrid functional methods, both of which have been widely used in addressing the band gap problem of semi-local functionals in DFT. We find that tuning the U value to obtain experimental bulk band gap and then using the obtained U value for defect calculations may result in over-localization of defect states. In the hybrid functional calculation, the band gap of BaZrS_(3)can be accurately obtained. We observe the formation of small S-atom clusters in both methods, which tend to self-passivate the defects from forming mid-gap levels. Even though in the hybrid functional calculations several relatively deep defects are observed, all of them exhibit too high formation energy to play a significant role if the materials are prepared under thermal equilibrium.BaZrS_(3)is thus expected to exhibit sufficient defect tolerance promising for photovoltaic and optoelectronic applications.展开更多
The characteristics of the upper ocean response to tropical cyclone wind (TCW) forcing in the northwestern Pacific were in- vestigated using satellite and Argo data, as well as an ocean general circulation model. In...The characteristics of the upper ocean response to tropical cyclone wind (TCW) forcing in the northwestern Pacific were in- vestigated using satellite and Argo data, as well as an ocean general circulation model. In particular, a case study was carried out on typhoon Rammasun, which passed through our study area during May 6-13, 2008. It is found that the local response fight under the TCW forcing is characterized by a quick deepening of the surface mixed layer, a strong latent heat loss to the atmosphere, and an intense upwelling near the center of typhoon, leading to a cooling of the oceanic surface layer that persists as a cold wake along the typhoon track. More interestingly, the upper ocean response exhibits a four-layer thermal structure, including a cooling layer near the surface and a warming layer right below, accompanied by another pair of cooling/warming layers in the thermocline. The formation of the surface cooling/warming layers can be readily explained by the strong vertical mixing induced by TCW forcing, while the thermal response in the thermocline is probably a result of the cyclone-driven upwelling and the associated advective processes.展开更多
文摘AIM:To compare diverse endoscopic interventions in the management of occluded uncovered self-expanding metal stents(SEMSs) that had been placed for palliative treatment of unresectable malignant biliary obstruction.METHODS:A retrospective review was undertaken in 4 tertiary endoscopic centers to determine optimal management of different types of occluded SEMSs.The technical success of performed treatment in occluded SEMSs,the patency of the stent,the need for re-intervention and the financial costs of each treatment were analyzed.RESULTS:Fifty four patients were included in the analysis;21 received Hanaro,19 Wallstent and 14 Flexus.For the relief of obstruction,a plastic stent was inserted in 24 patients,a second SEMS in 25 and mechanical cleaning was performed in 5 patients.The overall median second patency rates between second SEMSs and plastic stents did not differ(133 d for SEMSs vs 106 d for plastic stents;P = 0.856).Similarly,no difference was found between the overall survival of SEMS and plastic stent groups,and no procedure-related complications occurred.Incremental cost analysis showed that successive plastic stenting was a cost-saving strategy at least in Greece.CONCLUSION:Insertion of uncovered SEMSs or plastic stents is a safe and effective treatment for occluded uncovered SEMSs;insertion of plastic stents appears to be the most cost-effective strategy.
文摘The distribution of vertical stress for both active and passive state in the silo with a central innerdowncomer is reported in this paper. Experimental measurement of the axial distribution of vertical stress for bothactive and passive state in the silo are in good agreement with that predicted by theoretical analysis. The meanaxial stress is reduced due to the presence of the inner downcomer in the silo.
文摘A supply chain is a network that performs the procurement of raw material, the transportation of raw material to intermediate and end products, and the distribution of end products to retailers or customers. Installation and operation of distribution centers and all downstream members play a vital role in fulfilling the customers demand and have a great impact for supply chain management performance. In this paper we address a new approach for solving a supply chain optimization model to decide distribution centers based on environmental consideration.
文摘Objective: To evaluate the effect of the treatment modality guided by intraventricular intracranial pressure (ICP) monitoring on patients with severe traumatic brain injury (TBI). Methods: The clinical data of a group of 136 severely brain-injured patients admitted to Shanghai Neurosurgical Emergency Center from December 2004 to February 2006 were studied. Results: The intraventricular ICP monitor was placed in all the 136 patients via Kocher's pathway, Paine's pathway or intraoperative opened ventricle. In this series, the probe was placed during the procedure of craniotomy in 98 patients; for other 38 patients, the probe was placed initially to measure or to monitor ICE A stepwise protocol targeting at ICP control (420 mm Hg) and optimal cerebral perfusion pressure (CPP) maintenance (60-90 mm Hg) was deployed.Among them, 76 patients survived with good recovery, 14 with moderate disability, 24 with severe disability, 10 with vegetative state, and 12 died. Complications associated with intraventricular ICP monitoring included hemorrhage and infection. Hemorrhage occurred in 1 patient and infection in 5 patients. There were no unacceptable complications related to ICP monitoring. Conclusions: Ventricular access for 1CP monitoring can be safely and accurately achieved. ICP monitoring via ventriculostomy may facilitate an early and accurate intervention for severely brain-injured patients. The intraventricular ICP monitoring is a low-risk procedure and can yield great benefits for management of patients with severe TBI.
基金supported by the National Natural Science Foundation of China(21334002,51303057,51373054,91233113)the National Basic Research Program of China(2013CB834705,2014CB643504,2015CB655003)+1 种基金the Fundamental Research Funds for the Central Universities(2013ZZ0001)the Introduced Innovative R&D Team of Guangdong(201101C0105067115)
文摘Organic light-emitting diodes (OLEDs) have been extensively studied since the first efficient device based on small molecular luminescent materials was reported by Tang. Organic electroluminescent material, one of the centerpieces of OLEDs, has been the focus of studies by many material scientists. To obtain high luminosity and to keep material costs low, a few remarkable design concepts have been developed. Aggregation-induced emission (AIE) materials were invented to overcome the common fluorescence-quenching problem, and cross-dipole stacking of fluorescent molecules was shown to be an effective method to get high solid-state luminescence. To exceed the limit of internal quantum efficiency of conventional fluorescent materials, phosphorescent materials were successfully applied in highly efficient electroluminescent devices. Most recently, delayed flu- orescent materials via reverse-intersystem crossing (RISC) from triplet to singlet and the "hot exciton" materials based on hy- bridized local and charge-transfer (HLCT) states were developed to he a new generation of low-cost luminescent materials as efficient as phosphorescent materials. In terms of the device-fabrication process, solution-processible small molecular lumi- nescent materials possess the advantages of high purity (vs. polymers) and low procession cost (vs. vacuum deposition), which are garnering them increasing attention. Herein, we review the progress of the development of small-molecule luminescent materials with different design concepts and features, and also briefly examine future development tendencies of luminescent materials.
基金supported by the National Natural Science Foundation of China (11774365)the Natural Science Foundation of Shanghai (19ZR1421800)+4 种基金Shanghai International Cooperation Project (20520760900)the Opening Project and Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures (SKL201804 and SKL201803SIC) support by US National Science Foundation (NSF) (CBET1510121)US Department of Energy (DOE) (DEEE0007364)support by US NSF (CBET-1510948).support by US NSF (DMR-1506669)support by the Fundamental Research Funds for the Central Universities (DUT21RC(3) 033)。
文摘Chalcogenide perovskites(CPs) exhibiting lower band gaps than oxide perovskites and higher stability than halide perovskites are promising materials for photovoltaic and optoelectronic applications. For such applications, the absence of deep defect levels serving as recombination centers(dubbed defect tolerance) is a highly desirable property. Here,using density functional theory(DFT) calculations, we study the intrinsic defects in BaZrS_(3), a representative CP material.We compare Hubbard-U and hybrid functional methods, both of which have been widely used in addressing the band gap problem of semi-local functionals in DFT. We find that tuning the U value to obtain experimental bulk band gap and then using the obtained U value for defect calculations may result in over-localization of defect states. In the hybrid functional calculation, the band gap of BaZrS_(3)can be accurately obtained. We observe the formation of small S-atom clusters in both methods, which tend to self-passivate the defects from forming mid-gap levels. Even though in the hybrid functional calculations several relatively deep defects are observed, all of them exhibit too high formation energy to play a significant role if the materials are prepared under thermal equilibrium.BaZrS_(3)is thus expected to exhibit sufficient defect tolerance promising for photovoltaic and optoelectronic applications.
基金supported by the National Basic Research Pro-gram of China(Grant No.2013CB430302)the National Natural Science Foundation of China(Grant Nos.91128204,41321004,41475101,41421005)+1 种基金the China Scholarship Council,the CAS Strategic Priority Project(Grant Nos.XDA 11010301,XDA11010104)the National Natural Science Foundation of China-Shandong Joint Fund for Marine Science Research Centers(Grant No.U1406401)
文摘The characteristics of the upper ocean response to tropical cyclone wind (TCW) forcing in the northwestern Pacific were in- vestigated using satellite and Argo data, as well as an ocean general circulation model. In particular, a case study was carried out on typhoon Rammasun, which passed through our study area during May 6-13, 2008. It is found that the local response fight under the TCW forcing is characterized by a quick deepening of the surface mixed layer, a strong latent heat loss to the atmosphere, and an intense upwelling near the center of typhoon, leading to a cooling of the oceanic surface layer that persists as a cold wake along the typhoon track. More interestingly, the upper ocean response exhibits a four-layer thermal structure, including a cooling layer near the surface and a warming layer right below, accompanied by another pair of cooling/warming layers in the thermocline. The formation of the surface cooling/warming layers can be readily explained by the strong vertical mixing induced by TCW forcing, while the thermal response in the thermocline is probably a result of the cyclone-driven upwelling and the associated advective processes.