喘哮康口服液的免疫作用研究

目的:研究喘哮康口服液对免疫功能的影响。方法:测定被动过敏大鼠的皮肤蓝斑、冷应激小鼠的淋巴细胞、正常小鼠的碳廓清指数。结果:喘哮康口服液较大剂量时能抑制大鼠被动过敏皮肤反应;对正常状态下小鼠的碳粒廓清能力没有明显的影响,但能提高冷应激状态下鼠淋巴细胞的转化率。结论:喘哮康口服液具有增强机体免疫能力的作用。

疗伤片大鼠长期毒性试验研究

疗伤片0.3、0.8、2.0g(片重)/kg(体重)3个剂量连续灌胃大鼠3个月(12周),此时低、中、高剂量分别相当于70kg人临床剂量的10、24、58倍,生化检测结果显示疗伤片高剂量组大鼠的AST、T-B IL、BUN、ALB均有不同程度显著性变化;病理组织学检查结果显示高剂量组动物肝、肾脏病理变化加剧,两者结果表明疗伤片高剂量给药期间对大鼠的肝、肾脏器可能有一定的毒性作用,但于停药(2周)后均恢复正常,表明此毒性反应为一可逆性毒性反应。低、中剂量给药期及停药期大鼠状况、体重、血液指标、脏器系数、组织形态学观察均无明显差异或异常。说明疗伤片高剂量对大鼠的肝、肾功能有一定的毒性反应,此为可逆性毒性反应。

Recent advances in network pharmacology applications in Chinese herbal medicine

Network pharmacology is a new discipline based on the theory of systems biology and network analysis of biological systems to design the drugs.It comprehensively observes the intervention and influence of drugs on the disease network,and reveals the mystery of multi-molecular drugs synergistically acting on disease.These concepts reflect the ideas of multi-component,multi-target and system regulation,and have many similarities with the research ideas of traditional Chinese medicine,which focuses on syndrome differentiation and treatment,emphasizes the overall understanding of the etiology and pathogenesis.Network pharmacology can be used to predict and identify the target and active component of traditional herbal medicine,to clarify the mechanism of action,to scientifically explain the rules of the prescription,to explore the rules of real-world prescription,to discover new indications and new active compounds,and to study drug relocation,etc.The applications of network pharmacology in traditional herbal medicine were systematically summarized to demonstrate the significant value in these areas.

Network pharmacology： an important breakthrough in traditional Chinese medicine research

Objective： To study the relationship between traditional Chinese medicine （TCM） research and network pharmacology. Methods： Discuss the common features of TCM and network pharmacology through the analysis of the characteristics of TCM, the background of network pharmacology, so as better interpretation of TCM and in-depth understanding of TCM research and network pharmacology. Results： Multicomponent and multitarget characteristics of TCM as same as the study thought of network pharmacology. Network pharmacology breaks through the research model of linear and coincides with the complexity of TCM, provides technical support for rational design of TCM formulae, both and a new way in the research of TCM. It becomes a new strategy for modern TCM research. Conclusion： Network pharmacology is an important breakthrough in TCM research, its research promote modernization and internationalization process of TCM conduce to the research and development of TCM and have important significance for the integration of Chinese and Western medicine.