目的:研究短梗五加果多酚(Acanthopanax sessiliflorus fruit polyphenols,ASFP)对大鼠动脉粥样硬化(atherosclerosis,As)的预防作用,并探讨其作用机制。方法:40只雄性SD大鼠随机平均分成4组,每组10只。采用高脂饮食结合腹腔注射VD3的...目的:研究短梗五加果多酚(Acanthopanax sessiliflorus fruit polyphenols,ASFP)对大鼠动脉粥样硬化(atherosclerosis,As)的预防作用,并探讨其作用机制。方法:40只雄性SD大鼠随机平均分成4组,每组10只。采用高脂饮食结合腹腔注射VD3的方法建立As模型,不同剂量ASFP给药组自造模开始之日起分别灌胃150、75 mg/(kg·d)的ASFP,空白组和高脂饮食组大鼠灌胃等量生理盐水,各实验组连续处理12周后,检测大鼠血清生理生化水平并计算As指数;苏木素-伊红染色观察大鼠主动脉As病变情况;Western blot检测主动脉中黏附分子和丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路关键基因的蛋白表达水平。结果:与高脂饮食组相比,ASFP能显著降低大鼠血清中的血脂、黏附分子和炎症因子水平,减少主动脉中的脂质沉积,改善各层结构排列紊乱,显著降低主动脉中细胞间黏附分子-1、血管细胞黏附分子-1、磷酸化p38和磷酸化细胞外信号调节蛋白激酶1/2(phospho-extracellular signal regulated kinases 1/2,p-ERK1/2)的蛋白表达量。结论:ASFP具有预防As的作用,其作用可能与其降血脂和抑制p38 MAPK和ERK1/2 MAPK信号通路,进而抑制炎症因子的表达有关。展开更多
Electroencephalogram （EEG） based brain-computer interfaces allow users to communicate with the external environment by means of their EEG signals, without relying on the brain＇s usual output pathways such as muscle...Electroencephalogram （EEG） based brain-computer interfaces allow users to communicate with the external environment by means of their EEG signals, without relying on the brain＇s usual output pathways such as muscles. A popular application for EEGs is the EEG-based speller, which translates EEG signals into intentions to spell particular words, thus benefiting those suffering from severe disabilities, such as amyotrophic lateral sclerosis. Although the EEG-based English speller （EEGES） has been widely studied in recent years, few studies have focused on the EEG-based Chinese speller （EEGCS）. The EEGCS is more difficult to develop than the EEGES, because the English alphabet contains only 26 letters. By contrast, Chinese contains more than 11000 logographic characters. The goal of this paper is to survey the literature on EEGCS systems. First, the taxonomy of current EEGCS systems is discussed to get the gist of the paper. Then, a common framework unifying the current EEGCS and EEGES systems is proposed, in which the concept of EEG-based choice acts as a core component. In addition, a variety of current EEGCS systems are investigated and discussed to highlight the advances, current problems, and future directions for EEGCS.展开更多
文摘目的:研究短梗五加果多酚(Acanthopanax sessiliflorus fruit polyphenols,ASFP)对大鼠动脉粥样硬化(atherosclerosis,As)的预防作用,并探讨其作用机制。方法:40只雄性SD大鼠随机平均分成4组,每组10只。采用高脂饮食结合腹腔注射VD3的方法建立As模型,不同剂量ASFP给药组自造模开始之日起分别灌胃150、75 mg/(kg·d)的ASFP,空白组和高脂饮食组大鼠灌胃等量生理盐水,各实验组连续处理12周后,检测大鼠血清生理生化水平并计算As指数;苏木素-伊红染色观察大鼠主动脉As病变情况;Western blot检测主动脉中黏附分子和丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路关键基因的蛋白表达水平。结果:与高脂饮食组相比,ASFP能显著降低大鼠血清中的血脂、黏附分子和炎症因子水平,减少主动脉中的脂质沉积,改善各层结构排列紊乱,显著降低主动脉中细胞间黏附分子-1、血管细胞黏附分子-1、磷酸化p38和磷酸化细胞外信号调节蛋白激酶1/2(phospho-extracellular signal regulated kinases 1/2,p-ERK1/2)的蛋白表达量。结论:ASFP具有预防As的作用,其作用可能与其降血脂和抑制p38 MAPK和ERK1/2 MAPK信号通路,进而抑制炎症因子的表达有关。
基金Project supported by the China Scholarship Council,the National Natural Science Foundation of China(Nos.61673328,61673322,61402386,61305061,61203336,and 61273338)the Fundamental Research Funds for the Central Universities,China(No.20720160126)the National Basic Research Program(973)of China(No.2013CB329502)
文摘Electroencephalogram （EEG） based brain-computer interfaces allow users to communicate with the external environment by means of their EEG signals, without relying on the brain＇s usual output pathways such as muscles. A popular application for EEGs is the EEG-based speller, which translates EEG signals into intentions to spell particular words, thus benefiting those suffering from severe disabilities, such as amyotrophic lateral sclerosis. Although the EEG-based English speller （EEGES） has been widely studied in recent years, few studies have focused on the EEG-based Chinese speller （EEGCS）. The EEGCS is more difficult to develop than the EEGES, because the English alphabet contains only 26 letters. By contrast, Chinese contains more than 11000 logographic characters. The goal of this paper is to survey the literature on EEGCS systems. First, the taxonomy of current EEGCS systems is discussed to get the gist of the paper. Then, a common framework unifying the current EEGCS and EEGES systems is proposed, in which the concept of EEG-based choice acts as a core component. In addition, a variety of current EEGCS systems are investigated and discussed to highlight the advances, current problems, and future directions for EEGCS.
