原发性中枢神经系统淋巴瘤（primary central nervous system lymphomas,PCNSL）是指发生于脑、脊髓、脑脊膜等处的非霍奇金恶性淋巴组织肿瘤,无系统性淋巴瘤的表现,约占颅内恶性肿瘤的3%[1],多为B细胞型。结外NK/T细胞淋巴瘤多见于面...原发性中枢神经系统淋巴瘤（primary central nervous system lymphomas,PCNSL）是指发生于脑、脊髓、脑脊膜等处的非霍奇金恶性淋巴组织肿瘤,无系统性淋巴瘤的表现,约占颅内恶性肿瘤的3%[1],多为B细胞型。结外NK/T细胞淋巴瘤多见于面部中线结构附近,而原发于中枢神经系统者较少见。展开更多
目的探索MRI在多发性脑胶质瘤(multiple gliomas,MCG)和原发性中枢神经系统淋巴瘤(primary central nervous system lymphoma,PCNSL)鉴别诊断中的应用价值。方法收集了60例MCG患者和36例PCNSL患者,均为经手术病理确诊患者,所有患者均接...目的探索MRI在多发性脑胶质瘤(multiple gliomas,MCG)和原发性中枢神经系统淋巴瘤(primary central nervous system lymphoma,PCNSL)鉴别诊断中的应用价值。方法收集了60例MCG患者和36例PCNSL患者,均为经手术病理确诊患者,所有患者均接受了MRI平扫和增强扫描。对MCG和PCNSL病例的MRI图像的特点作比较分析。结果60例MCG患者共有180个病灶,其中93个(51.67%)位于额叶、顶叶、颞叶和岛叶,42个病灶(占23.33%)位于海马及海马旁回,45个(25.0%)位于其他部位(丘脑、脑干和小脑);36例PCNSL患者共100个病灶,78个病灶(78.00%)位于中线旁深部白质,22个(22.0%)分别位于胼胝体、额叶、顶叶、枕叶、小脑。两者MRI信号特征分析结果:MRI平扫MCG病灶大都呈团块或斑块状,其信号基本欠均匀,呈长T1WI、长T2WI信号,具有占位效应;PCNSL病灶大都呈实性团块或结节状,呈等长或稍长T1WI、T2WI信号,占位效应较MCG病灶轻微。MRI增强扫描MCG病灶之间和病灶内呈不相一致的强化程度;PCNSL病灶则强化程度较为均匀一致;MCG病灶伴囊变、出血者多于PCNSL病灶(P<0.05、P<0.01)。结论MRI显示,MCG和PCNSL的病灶位置、信号特征和强化程度各具特点,特别是两种病变的强化特征的差异可作为二者之间更准确可靠的影像学鉴别依据。展开更多
In order to elucidate the differences between systemic and central nervous system (CNS) immunity that are relevant to exacerbations of multiple sclerosis (MS), paired peripheral blood and cerebrospinal fluid (CSF) sam...In order to elucidate the differences between systemic and central nervous system (CNS) immunity that are relevant to exacerbations of multiple sclerosis (MS), paired peripheral blood and cerebrospinal fluid (CSF) samples obtained from 36 nontreated patients with relapsing-remitting MS (RRMS) were simultaneously examined using flow cytometry to determine the percentages of functional lymphocyte subsets, as well as enzyme-linked immunosorbent assays for measu- ring soluble immune mediators.Active RRMS patients (n = 27) were characterized by an increase in CD4+CXCR3+Th1 cells in blood as compared with inactive patients (n = 9), and this parameter was inversely correlated with plasma levels of IL-10 and IL-12p70. In contrast, an increase in the percentage of CD4+CD25+cells and a decrease in the percentage of CD8+CD11ahigh cells were features of CSF samples from those with active RRMS. Further, CSF CD4+CD25+cells had a close association with leukocyte counts as well as albumin and CXCL10 levels in the CSF, and, thus, could be useful as a measure for inflammatory reactions in the CNS. On the other hand, CD8+CD11ahigh cells may function as immunoregulatory cells, as their percentage in the CSF showed a positive correlation with CSF levels of the anti-inflammatory cytokine IL-4. These findings suggest that MS relapses occur in a combination with altered cell-mediated immunity that differs between the peripheral blood and CSF compartments, while measurement of lymphocyte subsets may be helpful for monitoring disease status.展开更多
文摘原发性中枢神经系统淋巴瘤（primary central nervous system lymphomas,PCNSL）是指发生于脑、脊髓、脑脊膜等处的非霍奇金恶性淋巴组织肿瘤,无系统性淋巴瘤的表现,约占颅内恶性肿瘤的3%[1],多为B细胞型。结外NK/T细胞淋巴瘤多见于面部中线结构附近,而原发于中枢神经系统者较少见。
文摘目的探索MRI在多发性脑胶质瘤(multiple gliomas,MCG)和原发性中枢神经系统淋巴瘤(primary central nervous system lymphoma,PCNSL)鉴别诊断中的应用价值。方法收集了60例MCG患者和36例PCNSL患者,均为经手术病理确诊患者,所有患者均接受了MRI平扫和增强扫描。对MCG和PCNSL病例的MRI图像的特点作比较分析。结果60例MCG患者共有180个病灶,其中93个(51.67%)位于额叶、顶叶、颞叶和岛叶,42个病灶(占23.33%)位于海马及海马旁回,45个(25.0%)位于其他部位(丘脑、脑干和小脑);36例PCNSL患者共100个病灶,78个病灶(78.00%)位于中线旁深部白质,22个(22.0%)分别位于胼胝体、额叶、顶叶、枕叶、小脑。两者MRI信号特征分析结果:MRI平扫MCG病灶大都呈团块或斑块状,其信号基本欠均匀,呈长T1WI、长T2WI信号,具有占位效应;PCNSL病灶大都呈实性团块或结节状,呈等长或稍长T1WI、T2WI信号,占位效应较MCG病灶轻微。MRI增强扫描MCG病灶之间和病灶内呈不相一致的强化程度;PCNSL病灶则强化程度较为均匀一致;MCG病灶伴囊变、出血者多于PCNSL病灶(P<0.05、P<0.01)。结论MRI显示,MCG和PCNSL的病灶位置、信号特征和强化程度各具特点,特别是两种病变的强化特征的差异可作为二者之间更准确可靠的影像学鉴别依据。
文摘In order to elucidate the differences between systemic and central nervous system (CNS) immunity that are relevant to exacerbations of multiple sclerosis (MS), paired peripheral blood and cerebrospinal fluid (CSF) samples obtained from 36 nontreated patients with relapsing-remitting MS (RRMS) were simultaneously examined using flow cytometry to determine the percentages of functional lymphocyte subsets, as well as enzyme-linked immunosorbent assays for measu- ring soluble immune mediators.Active RRMS patients (n = 27) were characterized by an increase in CD4+CXCR3+Th1 cells in blood as compared with inactive patients (n = 9), and this parameter was inversely correlated with plasma levels of IL-10 and IL-12p70. In contrast, an increase in the percentage of CD4+CD25+cells and a decrease in the percentage of CD8+CD11ahigh cells were features of CSF samples from those with active RRMS. Further, CSF CD4+CD25+cells had a close association with leukocyte counts as well as albumin and CXCL10 levels in the CSF, and, thus, could be useful as a measure for inflammatory reactions in the CNS. On the other hand, CD8+CD11ahigh cells may function as immunoregulatory cells, as their percentage in the CSF showed a positive correlation with CSF levels of the anti-inflammatory cytokine IL-4. These findings suggest that MS relapses occur in a combination with altered cell-mediated immunity that differs between the peripheral blood and CSF compartments, while measurement of lymphocyte subsets may be helpful for monitoring disease status.
