The title compound of karounidiol (C30H48O2), a main active triterpene component of snakegourd seed, was isolated from unsaponifiable matter of the seed oil of Trichosanthes kirilowii Maxim., and characterized by X-ra...The title compound of karounidiol (C30H48O2), a main active triterpene component of snakegourd seed, was isolated from unsaponifiable matter of the seed oil of Trichosanthes kirilowii Maxim., and characterized by X-ray diffraction analysis. It crystallizes in orthorhombic system, space group P212121 with C30H48O2CH3OHH2O (C31H54O4), a = 7.515(1), b = 14.407(1), c = 27.799(2) , V = 3009.8(5) 3, Z = 4, Dx = 1.087 g/cm3, Mr = 490.77, F(000) = 1088 and = 0.086 mm-1. The final R = 0.0840 and wR = 0.2289 for 2752 observed reflections (|F|2 ≥ 2|F|2). The molecular crystal structure of karounidiol shows relative stereochemistry of (3,13,14, 20)-3,29-dihydroxy-13-methyl-26-norolean-7,9(11)-diene. The molecule is composed of five six- membered rings with ring junctures of A/B trans, C/D trans and D/E cis.展开更多
This paper summarizes the progress on the total syntheses riod from 2006 to 2010. The overview focuses on the first of natural products accomplished in rnainland China during the petotal synthesis of natural products ...This paper summarizes the progress on the total syntheses riod from 2006 to 2010. The overview focuses on the first of natural products accomplished in rnainland China during the petotal synthesis of natural products of contemporary interest includ- ing alkaloids, cyclopeptides and cyclic depsipeptides, macrolides, terpenoids and steroids, saponins and glycosides. The development of novel synthetic strategies and methodologies, and application of new selective synthetic methods in the total syntheses of natural products are included as well.展开更多
基金the State Science and Technology Commission (No. 96-903-02-02)
文摘The title compound of karounidiol (C30H48O2), a main active triterpene component of snakegourd seed, was isolated from unsaponifiable matter of the seed oil of Trichosanthes kirilowii Maxim., and characterized by X-ray diffraction analysis. It crystallizes in orthorhombic system, space group P212121 with C30H48O2CH3OHH2O (C31H54O4), a = 7.515(1), b = 14.407(1), c = 27.799(2) , V = 3009.8(5) 3, Z = 4, Dx = 1.087 g/cm3, Mr = 490.77, F(000) = 1088 and = 0.086 mm-1. The final R = 0.0840 and wR = 0.2289 for 2752 observed reflections (|F|2 ≥ 2|F|2). The molecular crystal structure of karounidiol shows relative stereochemistry of (3,13,14, 20)-3,29-dihydroxy-13-methyl-26-norolean-7,9(11)-diene. The molecule is composed of five six- membered rings with ring junctures of A/B trans, C/D trans and D/E cis.
基金the National Natural Science Foundation of China (20832005,21072160,20902075)the National Basic Research Program (973 Program) of China (2010CB833200)+2 种基金the Natural Science Foundation of Fujian Province of China (2009J05037)the Specialized Research Fund for the Doctoral Program of Higher Education(20090121120007)the Scientific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Education of China for financial support
文摘This paper summarizes the progress on the total syntheses riod from 2006 to 2010. The overview focuses on the first of natural products accomplished in rnainland China during the petotal synthesis of natural products of contemporary interest includ- ing alkaloids, cyclopeptides and cyclic depsipeptides, macrolides, terpenoids and steroids, saponins and glycosides. The development of novel synthetic strategies and methodologies, and application of new selective synthetic methods in the total syntheses of natural products are included as well.
