OBJECTIVE： This study was designed to develop a disease-specific health-related quality of life （HR-QOL） measure for patients with post-stroke spasticity. METHODS; Based on responses from 20 patients with post-stro...OBJECTIVE： This study was designed to develop a disease-specific health-related quality of life （HR-QOL） measure for patients with post-stroke spasticity. METHODS; Based on responses from 20 patients with post-stroke spasticity and an extensive literature search, items potentially used to measure these patients＇ recovery status were identified and the Apoplexy Spastic-Paralysis Questionnaire （ASPQ） was formed. A sample of 106 patients was then tested twice using the ASPQ, the Self-rating Depression Scale （SDS） and the Stroke-specific Quality of Life （SS-QOL）. Clinicians also examined all the patients using the Ashworth Scale （AS）. Inter- nal reliability was assessed using Cronbach＇s coeffi- cient a, while construct validity was determined us- ing principal component analysis （PCA）. Empirical validity was evaluated between patients with de- pression and those without depression by single factor analysis. Sensitivity was examined by calcu- lating the Spearman correlation coefficient be- tween the changes in scores of the ASPQ, the AS and the SS-QOL. RESULTS： The ASPQ had adequate internal consis- tency reliability （a=0.874） and sensitivity, with sig- nificant correlations between the changes in scores of the AS, the SS-QOL and the ASPQ, with three do- mains. In a construct validity test, six factors were extracted; the overall variance explained by all fac- tors was 72.6%. For empirical validity, mean values of 19 items and 3 domains were all higher in the de- pressive patients than in the non-depressive pa- tients. CONCLUSION： The ASPQ is a reliable and valid self-rating scale for measuring the HR-QOL in pa- tients with post-stroke spasticity.展开更多
基金Supported by China National Funds for Young Scientists (81001583)the National Fundamental Research and Development Grant(973 program,2006CB504601)the National Science and Technology Infrastructure Program (2004DEA71040)
文摘OBJECTIVE： This study was designed to develop a disease-specific health-related quality of life （HR-QOL） measure for patients with post-stroke spasticity. METHODS; Based on responses from 20 patients with post-stroke spasticity and an extensive literature search, items potentially used to measure these patients＇ recovery status were identified and the Apoplexy Spastic-Paralysis Questionnaire （ASPQ） was formed. A sample of 106 patients was then tested twice using the ASPQ, the Self-rating Depression Scale （SDS） and the Stroke-specific Quality of Life （SS-QOL）. Clinicians also examined all the patients using the Ashworth Scale （AS）. Inter- nal reliability was assessed using Cronbach＇s coeffi- cient a, while construct validity was determined us- ing principal component analysis （PCA）. Empirical validity was evaluated between patients with de- pression and those without depression by single factor analysis. Sensitivity was examined by calcu- lating the Spearman correlation coefficient be- tween the changes in scores of the ASPQ, the AS and the SS-QOL. RESULTS： The ASPQ had adequate internal consis- tency reliability （a=0.874） and sensitivity, with sig- nificant correlations between the changes in scores of the AS, the SS-QOL and the ASPQ, with three do- mains. In a construct validity test, six factors were extracted; the overall variance explained by all fac- tors was 72.6%. For empirical validity, mean values of 19 items and 3 domains were all higher in the de- pressive patients than in the non-depressive pa- tients. CONCLUSION： The ASPQ is a reliable and valid self-rating scale for measuring the HR-QOL in pa- tients with post-stroke spasticity.
