胆红素过多可引起黄疸,胆红素的具体功能还没有搞清楚。然而,最近的一项研究表明,血液中胆红素浓度的轻度增高能防止动脉的阻塞。现在研究人员已掌握了胆红素与心脏病有关的新证据。盐湖城犹他州大学医学院Paul N Hop-kins等对有早期心...胆红素过多可引起黄疸,胆红素的具体功能还没有搞清楚。然而,最近的一项研究表明,血液中胆红素浓度的轻度增高能防止动脉的阻塞。现在研究人员已掌握了胆红素与心脏病有关的新证据。盐湖城犹他州大学医学院Paul N Hop-kins等对有早期心脏病表现的120名男性和41名女性进行研究。对他们进行血液检验,其中包括检验血中胆红素的浓度。把检验结果输入计算机,观察胆红素对心脏是否有保护作用。 Hopkins说,他惊奇地发现胆红素对心脏确实具有保护作用。展开更多
Objective: To evaluate relations between production and conjugation of biliru bin in the pathophysiology of jaundice in glucose- 6- phosophate dehydrogenase (G6PD) deficient neonates. Methods: Term and borderline prem...Objective: To evaluate relations between production and conjugation of biliru bin in the pathophysiology of jaundice in glucose- 6- phosophate dehydrogenase (G6PD) deficient neonates. Methods: Term and borderline premature (35- 37 week s gestational age), healthy, male, G6PD deficient neonates were studied close to the beginning of the 3rd day. Blood carboxyhaemogobin corrected for inspired CO (COHbc; an index of bilirubin production) and serum total conjugated bilirubin (TCB; a reflection of bilirubin conjugation) were measured in simultaneously dra wn blood samples by gas chromatography and reverse phase high performance liquid chromatography respectively. A bilirubin production- conjugation index compris ing COHbc/TCB was determined; a high index reflects imbalance between the biliru bin production and conjugation processes. COHbc and TCB individually and the pro duction- conjugation index were studied in relation to serum total bilirubin (S TB)- concentration. Results: Fifty one G6PD deficient neonates were sampled at 51 (8) hours. COHbc values did not correlate with STB (r = 0.22, p = 0.15). TCB did correlate inversely with STB (r = - 0.42, p = 0.004), and there was a posit ive correlation between the production- conjugation index and STB (r = 0.45, p = 0.002). The production- conjugation index (median (interquartile range))was h igher in the premature (n = 8) than term neonates (2.31 (2.12- 3.08) v 1.05 (0. 53- 1.81), p = 0.003). This difference was the result of changes in TCB. Conclu sions: The data show that jaundice in G6PD deficient neonates is the result of a n imbalance between production and conjugation of bilirubin with a tendency for inefficient bilirubin conjugation over increased haemolysis in its pathogenesis. Borderline premature infants are at especial risk of bilirubin production- con jugation imbalance.展开更多
文摘胆红素过多可引起黄疸,胆红素的具体功能还没有搞清楚。然而,最近的一项研究表明,血液中胆红素浓度的轻度增高能防止动脉的阻塞。现在研究人员已掌握了胆红素与心脏病有关的新证据。盐湖城犹他州大学医学院Paul N Hop-kins等对有早期心脏病表现的120名男性和41名女性进行研究。对他们进行血液检验,其中包括检验血中胆红素的浓度。把检验结果输入计算机,观察胆红素对心脏是否有保护作用。 Hopkins说,他惊奇地发现胆红素对心脏确实具有保护作用。
文摘Objective: To evaluate relations between production and conjugation of biliru bin in the pathophysiology of jaundice in glucose- 6- phosophate dehydrogenase (G6PD) deficient neonates. Methods: Term and borderline premature (35- 37 week s gestational age), healthy, male, G6PD deficient neonates were studied close to the beginning of the 3rd day. Blood carboxyhaemogobin corrected for inspired CO (COHbc; an index of bilirubin production) and serum total conjugated bilirubin (TCB; a reflection of bilirubin conjugation) were measured in simultaneously dra wn blood samples by gas chromatography and reverse phase high performance liquid chromatography respectively. A bilirubin production- conjugation index compris ing COHbc/TCB was determined; a high index reflects imbalance between the biliru bin production and conjugation processes. COHbc and TCB individually and the pro duction- conjugation index were studied in relation to serum total bilirubin (S TB)- concentration. Results: Fifty one G6PD deficient neonates were sampled at 51 (8) hours. COHbc values did not correlate with STB (r = 0.22, p = 0.15). TCB did correlate inversely with STB (r = - 0.42, p = 0.004), and there was a posit ive correlation between the production- conjugation index and STB (r = 0.45, p = 0.002). The production- conjugation index (median (interquartile range))was h igher in the premature (n = 8) than term neonates (2.31 (2.12- 3.08) v 1.05 (0. 53- 1.81), p = 0.003). This difference was the result of changes in TCB. Conclu sions: The data show that jaundice in G6PD deficient neonates is the result of a n imbalance between production and conjugation of bilirubin with a tendency for inefficient bilirubin conjugation over increased haemolysis in its pathogenesis. Borderline premature infants are at especial risk of bilirubin production- con jugation imbalance.
