The similarities of the non-linear chemical （NLC） fingerprints of Radix Glycyrrhizaes from four producing areas and eight other traditional Chinese medicines （TCMs） were calculated, using a systemic similarity cal...The similarities of the non-linear chemical （NLC） fingerprints of Radix Glycyrrhizaes from four producing areas and eight other traditional Chinese medicines （TCMs） were calculated, using a systemic similarity calculation method proposed and three other main calculation ones （Euclidean distance, correlation coefficient and included angle cosine）. All of the correlation coefficient similarities of different TCMs are higher than 0.952, and the included angle cosines are all higher than 0.962. So, both the conelation coefficient and included angle cosine similarities are unable to be used as the criteria for quantitatively evaluating the similarities of NLC fingerprints of TCMs. Although all of the Euclidean distance similarities of Berry Liquorices from four producing areas are less than 73, those of the other eight TCMs are all more than 180. The Euclidean distance cannot reflect the relative magnitudes of the feature differences in the NLC fingerprints very correctly. The systemic similarity method is the best among the four ones. All of the systemic similarities of Berry Liquorices from the four producing areas are higher than 0.962, while those of the other eight TCMs are all lower than 0.805, and the systemic similarity can reflect the differences between samples most faithfully, and can be used as a quantitative one evaluating the similarities of NLC fingerprints of TCMs, by which TCM could be distinguished and evaluated quickly, simply and exactly.展开更多
Diabetic nephropathy is one of the most serious complications of diabetes mellitus. In the early stage, edema and proteinuria are the main clinical manifestations. In the later stage, glomerulosclerosis and interstiti...Diabetic nephropathy is one of the most serious complications of diabetes mellitus. In the early stage, edema and proteinuria are the main clinical manifestations. In the later stage, glomerulosclerosis and interstitial fibrosis will occur. And the prognosis is poor. Nowadays, traditional Chinese medicine has a remarkable curative effect in the treatment of diabetic nephropathy. There are more and more studies on the treatment of diabetic nephropathy with traditional Chinese medicine, but most of them focus on the syndromes of diabetic nephropathy, which are short of in-depth research and summary on the mechanism of Chinese herbal prescriptions. In this paper, the traditional Chinese medicine inheritance support system and network pharmacology BATMAN-TCM software were used to collect and analyze the relevant literature. It was found that the core compatibility of Shanzhuyu, Fuling and Shuyu in the treatment of diabetic nephropathy is closely related to the signal transduction pathway and target of diabetic nephropathy, and has a positive effect on the improvement of clinical symptoms such as proteinuria, glycometabolism disorder, edema, etc. This paper explores the core compatibility of Shanzhuyu, Fuling and Shuyu on diabetic nephropathy, in order to provide reference for clinical treatment.展开更多
Liver injury remains a significant global health problem and has a variety of causes,including oxidative stress(OS),inflammation,and apoptosis of liver cells.There is currently no curative therapy for this disorder.Sa...Liver injury remains a significant global health problem and has a variety of causes,including oxidative stress(OS),inflammation,and apoptosis of liver cells.There is currently no curative therapy for this disorder.Sanwei Ganjiang Prescription(SWGJP),derived from traditional Chinese medicine(TCM),has shown its effectiveness in long-term liver damage therapy,although the underlying molecular mechanisms are still not fully understood.To explore the underlining mechanisms of action for SWGJP in liver injury from a holistic view,in the present study,a systems pharmacology approach was developed,which involved drug target identification and multilevel data integration analysis.Using a comprehensive systems approach,we identified 43 candidate compounds in SWGJP and 408 corresponding potential targets.We further deciphered the mechanisms of SWGJP in treating liver injury,including compound-target network analysis,target-function network analysis,and integrated pathways analysis.We deduced that SWGJP may protect hepatocytes through several functional modules involved in liver injury integrated-pathway,such as Nrf2-dependent anti-oxidative stress module.Notably,systems pharmacology provides an alternative way to investigate the complex action mode of TCM.展开更多
基金Project(2009GJD20033) supported by the National Science and Technology Ministry of China
文摘The similarities of the non-linear chemical （NLC） fingerprints of Radix Glycyrrhizaes from four producing areas and eight other traditional Chinese medicines （TCMs） were calculated, using a systemic similarity calculation method proposed and three other main calculation ones （Euclidean distance, correlation coefficient and included angle cosine）. All of the correlation coefficient similarities of different TCMs are higher than 0.952, and the included angle cosines are all higher than 0.962. So, both the conelation coefficient and included angle cosine similarities are unable to be used as the criteria for quantitatively evaluating the similarities of NLC fingerprints of TCMs. Although all of the Euclidean distance similarities of Berry Liquorices from four producing areas are less than 73, those of the other eight TCMs are all more than 180. The Euclidean distance cannot reflect the relative magnitudes of the feature differences in the NLC fingerprints very correctly. The systemic similarity method is the best among the four ones. All of the systemic similarities of Berry Liquorices from the four producing areas are higher than 0.962, while those of the other eight TCMs are all lower than 0.805, and the systemic similarity can reflect the differences between samples most faithfully, and can be used as a quantitative one evaluating the similarities of NLC fingerprints of TCMs, by which TCM could be distinguished and evaluated quickly, simply and exactly.
文摘Diabetic nephropathy is one of the most serious complications of diabetes mellitus. In the early stage, edema and proteinuria are the main clinical manifestations. In the later stage, glomerulosclerosis and interstitial fibrosis will occur. And the prognosis is poor. Nowadays, traditional Chinese medicine has a remarkable curative effect in the treatment of diabetic nephropathy. There are more and more studies on the treatment of diabetic nephropathy with traditional Chinese medicine, but most of them focus on the syndromes of diabetic nephropathy, which are short of in-depth research and summary on the mechanism of Chinese herbal prescriptions. In this paper, the traditional Chinese medicine inheritance support system and network pharmacology BATMAN-TCM software were used to collect and analyze the relevant literature. It was found that the core compatibility of Shanzhuyu, Fuling and Shuyu in the treatment of diabetic nephropathy is closely related to the signal transduction pathway and target of diabetic nephropathy, and has a positive effect on the improvement of clinical symptoms such as proteinuria, glycometabolism disorder, edema, etc. This paper explores the core compatibility of Shanzhuyu, Fuling and Shuyu on diabetic nephropathy, in order to provide reference for clinical treatment.
基金supported by the National Natural Science Foundation of China(Nos.81603318,81473740,and 81673627)Guangdong Provincial Major Science and Technology for Special Program of China(No.2015A030302072)+2 种基金Guangdong Provincial Major Science and Technology for Special Program of China(No.2015A030302071)the Guangzhou Science Technology and Innovation Commission Technology Research Projects(No.201805010005)the Guangzhou Science Technology and Innovation Commission Technology Research Projects(No.201607010333)
文摘Liver injury remains a significant global health problem and has a variety of causes,including oxidative stress(OS),inflammation,and apoptosis of liver cells.There is currently no curative therapy for this disorder.Sanwei Ganjiang Prescription(SWGJP),derived from traditional Chinese medicine(TCM),has shown its effectiveness in long-term liver damage therapy,although the underlying molecular mechanisms are still not fully understood.To explore the underlining mechanisms of action for SWGJP in liver injury from a holistic view,in the present study,a systems pharmacology approach was developed,which involved drug target identification and multilevel data integration analysis.Using a comprehensive systems approach,we identified 43 candidate compounds in SWGJP and 408 corresponding potential targets.We further deciphered the mechanisms of SWGJP in treating liver injury,including compound-target network analysis,target-function network analysis,and integrated pathways analysis.We deduced that SWGJP may protect hepatocytes through several functional modules involved in liver injury integrated-pathway,such as Nrf2-dependent anti-oxidative stress module.Notably,systems pharmacology provides an alternative way to investigate the complex action mode of TCM.
