Stroke is the leading cause of human disability with limited effective drugs availability. The disruption of multiple signaling pathways in stroke makes developing new drugs be difficult. Traditional Chinese medicine(...Stroke is the leading cause of human disability with limited effective drugs availability. The disruption of multiple signaling pathways in stroke makes developing new drugs be difficult. Traditional Chinese medicine(TCM) has its unique advantage in targeting multiple signaling pathways with multiple components. Many TCM formulas have the potential for neuroprotection and neurogenesis, but well-designed clinical trials are insufficient and underlying mechanisms unclear. Herein, we introduce the commonly used TCM formulas for stroke treatment and selectively introduce two classic formulas, An Gong Niu Huang(AGNH) pill and Bu Yang Huan Wu Decoction(BYHWD) for neuroprotection and neurogenesis, respectively. Current scientific evidence and clinical trials indicate AGNH pill could be an effective neuroprotective formula as adjunct therapy with relative safety. On the other hand, as a representative TCM formula for post stroke disability, BYHWD could improve the neurological outcome with its neuroprotective and neurogenic effects. The underlying mechanisms could be attributed to the modulation of multiple molecular targets with its multiple components. In conclusion, TCM formulas could be potential adjunct therapies for stroke treatment. The clinical efficacies and molecular mechanisms of promoting neuroprotection and neurogenesis remain to be further studies.展开更多
Objective: To observe the therapeutic effect of the integrated acupuncture-moxibustio n and herbal therapies for facial paralysis. Methods: A total of 68 cases of facial paralysis were treated by integration of acupun...Objective: To observe the therapeutic effect of the integrated acupuncture-moxibustio n and herbal therapies for facial paralysis. Methods: A total of 68 cases of facial paralysis were treated by integration of acupunct ure-moxibustion and herbal therapies. For acu-moxibustion, Yifeng (翳风 TE 17) , Dicang (地仓 ST 4), Jiache (颊车 ST 6), Yangbai (阳白 GB 14), Hegu (合谷 LI 4), etc. were used. In addition, for facial palsy patients with wind-phlegm blockin g meridian-collaterals and wind-stirring due to yin defi ciency types in the acute stage, Modified Qian Zheng San (牵正散 Powder for Treating Wry-mouth) and Modi f ied Zhen Gan Xi Feng Tang (镇肝熄风汤 Tranquilizing Liver-wind Decoction) were u sed respectively; and for those in convalescent stage and sequela stage, Modifie d Danggui Bu Xue Tang (当归补血汤 Ghinese Angelica Decoction for Replenishing Bl ood) + Qian Zheng San (Powder for Treating Wry-mouth) and Modified Bu Yang Hu an Wu Tang (补阳还五汤 Decoction Invigorating Yang for Recuperation) were employed. Results: After the treatment, the curative rate of the 68 cases a ccounted for 90 % of the total cases, the remarkably effective 6%, the improved 3% and the poor 1% respectively. Conclusion: The therapeutic effectiveness of the integrated tre atment of acupuncture-moxibustion and herbal therapies for facial paralysis is certain.展开更多
基金funding support from the Hong Kong Innovation and Technology Commission ITF grant (UIM/289)Grant from National Natural Science Foundation of China (No. 31570855)Contract Research Project of Beijing Tong Ren Tang Chinese Medicine Co. Ltd.
文摘Stroke is the leading cause of human disability with limited effective drugs availability. The disruption of multiple signaling pathways in stroke makes developing new drugs be difficult. Traditional Chinese medicine(TCM) has its unique advantage in targeting multiple signaling pathways with multiple components. Many TCM formulas have the potential for neuroprotection and neurogenesis, but well-designed clinical trials are insufficient and underlying mechanisms unclear. Herein, we introduce the commonly used TCM formulas for stroke treatment and selectively introduce two classic formulas, An Gong Niu Huang(AGNH) pill and Bu Yang Huan Wu Decoction(BYHWD) for neuroprotection and neurogenesis, respectively. Current scientific evidence and clinical trials indicate AGNH pill could be an effective neuroprotective formula as adjunct therapy with relative safety. On the other hand, as a representative TCM formula for post stroke disability, BYHWD could improve the neurological outcome with its neuroprotective and neurogenic effects. The underlying mechanisms could be attributed to the modulation of multiple molecular targets with its multiple components. In conclusion, TCM formulas could be potential adjunct therapies for stroke treatment. The clinical efficacies and molecular mechanisms of promoting neuroprotection and neurogenesis remain to be further studies.
文摘Objective: To observe the therapeutic effect of the integrated acupuncture-moxibustio n and herbal therapies for facial paralysis. Methods: A total of 68 cases of facial paralysis were treated by integration of acupunct ure-moxibustion and herbal therapies. For acu-moxibustion, Yifeng (翳风 TE 17) , Dicang (地仓 ST 4), Jiache (颊车 ST 6), Yangbai (阳白 GB 14), Hegu (合谷 LI 4), etc. were used. In addition, for facial palsy patients with wind-phlegm blockin g meridian-collaterals and wind-stirring due to yin defi ciency types in the acute stage, Modified Qian Zheng San (牵正散 Powder for Treating Wry-mouth) and Modi f ied Zhen Gan Xi Feng Tang (镇肝熄风汤 Tranquilizing Liver-wind Decoction) were u sed respectively; and for those in convalescent stage and sequela stage, Modifie d Danggui Bu Xue Tang (当归补血汤 Ghinese Angelica Decoction for Replenishing Bl ood) + Qian Zheng San (Powder for Treating Wry-mouth) and Modified Bu Yang Hu an Wu Tang (补阳还五汤 Decoction Invigorating Yang for Recuperation) were employed. Results: After the treatment, the curative rate of the 68 cases a ccounted for 90 % of the total cases, the remarkably effective 6%, the improved 3% and the poor 1% respectively. Conclusion: The therapeutic effectiveness of the integrated tre atment of acupuncture-moxibustion and herbal therapies for facial paralysis is certain.
