中药陈药研究现状及思路探讨

目的:为中药陈药理论研究提供借鉴和思路。方法:挖掘本草文献,梳理现代研究文献,分析中药陈药应用历史和特色,明确研究现状和存在问题,并提出研究思路。结果:中药陈药应用历史悠久,国内学者对其应用进行了研究,但仍存在陈药的必要性、原理、时限等不明确以及研究方法不恰当等问题;其研究应该在固定并注意陈化条件下,引入过程论思想,采用"自始至终(从新品到陈品)"的研究思路。结论:中药陈药应用是中医临床一大特色,应深入研究陈化过程,为中药陈用理论的现代研究奠定基础。

Early metabolism evaluation making traditional Chinese medicine effective and safe therapeutics

Increasing attention is being paid to the scientific evaluation of traditional Chinese medicine （TCM）. As many TCMs are capable of biotransformation in the gastrointestinal tract, attention to biotransforrnation of TCM in the gastrointestinal tract may lead to discovery of the active components and active mechanisms. In this article, we review reports that host metabolic enzymes and intestinal bacteria may be responsible for the metabolism of TCM. Good understanding of the in vivo course of TCM will help us to know how to conduct metabolism evaluation of TCM by using in vitro human-derived system. This evaluation system will create new views on TCM as effective and safe therapeutic agents.