The purpose of this study was to determine the association of vaginal pH ≥ 5.0 and vaginal neutrophils >5 per oil field with preterm rupture of membranes (PPROM). This was a secondary analysis of the Vaginal Infec...The purpose of this study was to determine the association of vaginal pH ≥ 5.0 and vaginal neutrophils >5 per oil field with preterm rupture of membranes (PPROM). This was a secondary analysis of the Vaginal Infections and Prematurity cohort, and was comprised of 12,734 evaluable women enrolled between 23 and 26 weeks’ gestation. Women were tested for sexually transmitted infections and vaginal pH. Gram- stained smears were used for the detection of neutrophils. In this analysis, 5751 (41.3% ) women had neutrophils >5 per oil field, and 2500 (18.0% ) had pH ≥ 5.0. Both elevated pH and neutrophils were present in 1149 women (8.3% ). The concomitant presence of both neutrophils and elevated pH was significantly associated with PPROM at 24 to 32 weeks. Elevated vaginal pH and neutrophils are most strongly associated with early thirdtrimester PPROM, reflecting the importance of infection and/or inflammation in the pathogenesis of this condition.展开更多
Objectives The study assessed racia l differences in vaginal pH among women without bacterial vag inosis.Study design Data from the Vaginal Infections and Prematurity(VIP)Study were analyzed.From 1984to 1989,13,917lar...Objectives The study assessed racia l differences in vaginal pH among women without bacterial vag inosis.Study design Data from the Vaginal Infections and Prematurity(VIP)Study were analyzed.From 1984to 1989,13,917largely low -income women were enrolled during routine prenatal visits from 23to 26weeks’gestation.Vaginal cultures,Gram stains,and pH levels were colle cted.Comparisons of pH by race were made among women with G ram stain scores<7and without trichomoniasis before and after ad-justment for actual Gram stain score.Results Amongwomen with Gram stain scores<7,there was a modest but statis-tically significant racial differe nce in vaginal pH level.However,after controlling for diff erence in Gram stain score,age,and study site,there was no longer a signifi-cant difference in vaginal pH.Conclusion There is no sig-nificant difference in vaginal pH le vel between black and white women after controlling for di fferences in confounding factors,particularly vaginal flora.展开更多
文摘The purpose of this study was to determine the association of vaginal pH ≥ 5.0 and vaginal neutrophils >5 per oil field with preterm rupture of membranes (PPROM). This was a secondary analysis of the Vaginal Infections and Prematurity cohort, and was comprised of 12,734 evaluable women enrolled between 23 and 26 weeks’ gestation. Women were tested for sexually transmitted infections and vaginal pH. Gram- stained smears were used for the detection of neutrophils. In this analysis, 5751 (41.3% ) women had neutrophils >5 per oil field, and 2500 (18.0% ) had pH ≥ 5.0. Both elevated pH and neutrophils were present in 1149 women (8.3% ). The concomitant presence of both neutrophils and elevated pH was significantly associated with PPROM at 24 to 32 weeks. Elevated vaginal pH and neutrophils are most strongly associated with early thirdtrimester PPROM, reflecting the importance of infection and/or inflammation in the pathogenesis of this condition.
文摘Objectives The study assessed racia l differences in vaginal pH among women without bacterial vag inosis.Study design Data from the Vaginal Infections and Prematurity(VIP)Study were analyzed.From 1984to 1989,13,917largely low -income women were enrolled during routine prenatal visits from 23to 26weeks’gestation.Vaginal cultures,Gram stains,and pH levels were colle cted.Comparisons of pH by race were made among women with G ram stain scores<7and without trichomoniasis before and after ad-justment for actual Gram stain score.Results Amongwomen with Gram stain scores<7,there was a modest but statis-tically significant racial differe nce in vaginal pH level.However,after controlling for diff erence in Gram stain score,age,and study site,there was no longer a signifi-cant difference in vaginal pH.Conclusion There is no sig-nificant difference in vaginal pH le vel between black and white women after controlling for di fferences in confounding factors,particularly vaginal flora.
