AIM： TO assess feasibility, tolerability and efficacy of gemcitabine-based chemotherapy in patients ≥ 75 years old with advanced pancreatic cancer. METHODS： All consecutive patients ≥ 75 years old with advanced pa...AIM： TO assess feasibility, tolerability and efficacy of gemcitabine-based chemotherapy in patients ≥ 75 years old with advanced pancreatic cancer. METHODS： All consecutive patients ≥ 75 years old with advanced pancreatic adenocarcinoma were included in this retrospective study. Necessary criteria to receive chemotherapy were： performance status 0-2, adequate biological parameters and no serious comorbidities. Other patients received best supportive care （BSC）. RESULTS： Thirty-eight patients （53% women, median age 78 years, range 75-84） with pancreatic cancer （metastatic： n = 20, locally advanced： n = 18） were studied. Among them, 30 （79%） were able to receive chemotherapy [median number： 9 infusions （1-45）]. Six patients （23%） had at least one episode of grade 3 neutropenia and one patient developed a grade 3 hemolytic-uremic syndrome. No toxic death occurred. Three patients （11%） had a partial tumor response, 13 （46%） had a stable disease and 12 （43%） had a tumor progression. Median survival was 9.1 mo （metastatic： 6.9 too, locally advanced： 11.4 too）. CONCLUSION： Tolerance and efficacy of gemcitabinebased chemotherapy is acceptable in elderly patients in good condition, with similar results to younger patients.展开更多
The Daqing Mountains area comprises a typical occurrence of the Khondalite Belt in the Western Block of the North China Craton (NCC). In this area, both early and late Paleoproterozoic metasedimentary rocks have been ...The Daqing Mountains area comprises a typical occurrence of the Khondalite Belt in the Western Block of the North China Craton (NCC). In this area, both early and late Paleoproterozoic metasedimentary rocks have been identified in what was originally called the Upper Wula Mountains "Subgroup". Six metasedimentary rock samples yielded SHRIMP U-Pb zircon ages of 2.56-2.04 Ga for detrital and 1.96-1.83 Ga for metamorphic zircons. Based on these data and previously published results, the following conclusions can be drawn: 1) The source region for the late Paleoproterozoic detrital sedimentary rocks is mainly 2.55 2.4 and 2.2 2.04 Ga in age, consistent with the early Precambrian geological history identified widely in the basement of the NCC. 2) The majority of sedimentary rocks of the khondalite series were deposited between 2.04 and 1.95 Ga, and then in a protracted period (1.96 and 1.83 Ga) underwent a complex history of amphibolite to granulite-facies metamorphism.展开更多
A new SIMS U-Pb zircon age of 654.2 ± 2.7 Ma was reported from the middle Datangpo Formation in Changyang County of Hubei Province, China. The age is identical with that of 654 ± 3.8 Ma from the top Datangpo...A new SIMS U-Pb zircon age of 654.2 ± 2.7 Ma was reported from the middle Datangpo Formation in Changyang County of Hubei Province, China. The age is identical with that of 654 ± 3.8 Ma from the top Datangpo Formation in western Hunan Province, revealing that the volcanic activities （- 654 Ma） may have occurred widely in South China. The occurrence of the tuff beds （-654 Ma） at different intervals of the Datangpo Formation indicates that the erosion process after the Datangpo deposition varied significantly in different areas. It is thus consequently suggested that the rift in South China was active until the Nantuo glaciation. In addition, the new age confirms that the Nantuo glaciation started much later than 654 Ma.展开更多
文摘AIM： TO assess feasibility, tolerability and efficacy of gemcitabine-based chemotherapy in patients ≥ 75 years old with advanced pancreatic cancer. METHODS： All consecutive patients ≥ 75 years old with advanced pancreatic adenocarcinoma were included in this retrospective study. Necessary criteria to receive chemotherapy were： performance status 0-2, adequate biological parameters and no serious comorbidities. Other patients received best supportive care （BSC）. RESULTS： Thirty-eight patients （53% women, median age 78 years, range 75-84） with pancreatic cancer （metastatic： n = 20, locally advanced： n = 18） were studied. Among them, 30 （79%） were able to receive chemotherapy [median number： 9 infusions （1-45）]. Six patients （23%） had at least one episode of grade 3 neutropenia and one patient developed a grade 3 hemolytic-uremic syndrome. No toxic death occurred. Three patients （11%） had a partial tumor response, 13 （46%） had a stable disease and 12 （43%） had a tumor progression. Median survival was 9.1 mo （metastatic： 6.9 too, locally advanced： 11.4 too）. CONCLUSION： Tolerance and efficacy of gemcitabinebased chemotherapy is acceptable in elderly patients in good condition, with similar results to younger patients.
基金supported by National Natural Science Foundation of China (Grant No.41002062)Scientific Research Program of the Ministry of Science and Technology of China (Grant No. J0901)the Key Program of the Land and Resource Ministry of China (Grant Nos. 1212011120151,1212010811033, 1212010711815)
文摘The Daqing Mountains area comprises a typical occurrence of the Khondalite Belt in the Western Block of the North China Craton (NCC). In this area, both early and late Paleoproterozoic metasedimentary rocks have been identified in what was originally called the Upper Wula Mountains "Subgroup". Six metasedimentary rock samples yielded SHRIMP U-Pb zircon ages of 2.56-2.04 Ga for detrital and 1.96-1.83 Ga for metamorphic zircons. Based on these data and previously published results, the following conclusions can be drawn: 1) The source region for the late Paleoproterozoic detrital sedimentary rocks is mainly 2.55 2.4 and 2.2 2.04 Ga in age, consistent with the early Precambrian geological history identified widely in the basement of the NCC. 2) The majority of sedimentary rocks of the khondalite series were deposited between 2.04 and 1.95 Ga, and then in a protracted period (1.96 and 1.83 Ga) underwent a complex history of amphibolite to granulite-facies metamorphism.
基金supported by the MLR Public Benefit Research Foundation(201411044)the National Basic Research Program of China(2013CB835005)+1 种基金the National Natural Science Foundation of China(41172035)China Geological Survey(12120114077901)
文摘A new SIMS U-Pb zircon age of 654.2 ± 2.7 Ma was reported from the middle Datangpo Formation in Changyang County of Hubei Province, China. The age is identical with that of 654 ± 3.8 Ma from the top Datangpo Formation in western Hunan Province, revealing that the volcanic activities （- 654 Ma） may have occurred widely in South China. The occurrence of the tuff beds （-654 Ma） at different intervals of the Datangpo Formation indicates that the erosion process after the Datangpo deposition varied significantly in different areas. It is thus consequently suggested that the rift in South China was active until the Nantuo glaciation. In addition, the new age confirms that the Nantuo glaciation started much later than 654 Ma.
