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单基因遗传病发病风险的临床估计与教学
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作者 涂冰 柳小年 《卫生职业教育》 2002年第12期56-57,共2页
遗传咨询涉及遗传学与医学,前者包括遗传病的传递方式、系谱分析、再发风险估计,后者包括疾病诊断、产前诊断、预后防治.
关键词 单基因遗传病 发病风险 临床估计 估算方法
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产后出血量的理论评估和临床估计
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作者 吴长阳 《河南中医》 2014年第B11期372-372,共1页
目的探讨产后出血量的理论评估,分析它与临床估计量之间的差异.方法:对我院124 名产后出血患者,以产前和产后三天患者的血红蛋白(HB)、红细胞压积变化(HCT)和红细胞计数结合血容量估算产后出血量,对比临床估计量进行回顾性分析.结... 目的探讨产后出血量的理论评估,分析它与临床估计量之间的差异.方法:对我院124 名产后出血患者,以产前和产后三天患者的血红蛋白(HB)、红细胞压积变化(HCT)和红细胞计数结合血容量估算产后出血量,对比临床估计量进行回顾性分析.结果:理论估计值和临床估计值之间有明显差异.结论:理论估计产后出血量对临床评估出血量有一定的指导意义. 展开更多
关键词 产后出血 出血量估计 理论评估 临床估计
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浅谈对各类脱水患者补液计划的制定及体会
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作者 李进伟 《中国医药指南》 2011年第4期44-45,共2页
机体由于水的摄入不足或丧失过多引起体液减少的现象,称脱水。脱水不仅是水的丢失,同时伴有电解质(主要是钠离子失)的丢失。合理早期的补液疗法是防治脱水、降低病死率的关键。
关键词 脱水 治疗 临床估计 体会
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食道癌的等中心定位
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作者 陈财福 肖震宇 《赣南医学院学报》 2006年第1期95-95,共1页
关键词 等中心定位 食道癌 定位准确性 晚期病人 放射治疗 恶性肿瘤 食道病变 临床估计 正常组织 模拟定位
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Subclinical hypothyroidism is associated with lipid-rich plaques in patients with coronary artery disease as assessed by optical coherence tomography 被引量:5
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作者 Xiao-Qing CAI Feng TIAN +6 位作者 Tian-Wen HAN Dong-Kai SHAN Yang LIU Wei-Jun YIN Jing Jing Qiang Xu Yun-Dai CHEN 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2018年第8期534-539,共6页
Background Subclinical hypothyroidism (SCH) has recently been acknowledged as an unconventional risk factor for coronary artery disease (CAD) and characterized by poor prognosis, which may be due to atheroscleroti... Background Subclinical hypothyroidism (SCH) has recently been acknowledged as an unconventional risk factor for coronary artery disease (CAD) and characterized by poor prognosis, which may be due to atherosclerotic plaque characteristics. We conducted this study to observe coronary plaque characteristics in coronary artery disease patients with concomitant SCH. Methods Patients with coronary artery disease were enrolled in the study and divided into an SCH group (patients, n = 26; plaques, n = 35) and a non-SCH group (patients, n = 52; plaques, n = 66). They were divided 1:2 according to propensity-matched analysis including age, diabetes mellitus, gender, CAD severity and culprit vessel. Optical coherence tomography (OCT) imaging was performed on all patients, and images were analyzed by two inde- pendent investigators. Lipid-rich plaques (LRP), the precursor of vulnerable plaques, were defined as having more than one quadrant occu- pied with lipid pool. Maximum lipid arcs were simultaneously recorded. Fibrotic plaques and calcific plaques were also identified. The pres- ence of coronary dissection, plaque erosion, thrombus, macrophage, calcific nodule, thin-cap fibroatheroma and micro channel were all noted. Results The ratio of LRP in SCH group was significantly higher than that in non-SCH group (54% vs. 30.3%, P = 0.037). That was the case as well for the maximum lipid arcs value (181.5°± 61.6° vs. 142.1° 4± 35.9°, p = 0.046). While thin-cap fibroatheroma (TCFA) was detected, no difference was identified between the two groups in either TCFA ratio (20% vs. 16.7%, P = 0.579) or fibrous cap thickness (57.5 4± 14.0 vs. 63.5 4±10.7 gin, P = 0.319). Other OCT characteristics such as dissection, plaque erosion, thrombus, macrophage shadow and calcific nodule were also similar. ConcLusion Higher ratio of LRP with greater lipid arc in SCH patients may be related to the plaque instability and poor prognosis in CAD patients with SCH. 展开更多
关键词 Coronary artery disease Optical coherence tomography Plaque characteristics Subclinical hypothyroidism
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血液透析症状性低血压和难治性高血压患者相对血容量变化的比较 被引量:22
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作者 严玉澄 林爱武 钱家麒 《中华肾脏病杂志》 CAS CSCD 北大核心 2005年第7期417-420,共4页
目的对症状性低血压(SH)和难治性高血压(RH)患者血透中相对血容量(RBV)的变化进行比较研究。方法选取SH患者15例和RH患者13例,通过血容量监测仪观察透析前和透析后每小时的RBV,BP,HR及超滤量(UV)。SH组共149次,RH组146次,比较两组各项... 目的对症状性低血压(SH)和难治性高血压(RH)患者血透中相对血容量(RBV)的变化进行比较研究。方法选取SH患者15例和RH患者13例,通过血容量监测仪观察透析前和透析后每小时的RBV,BP,HR及超滤量(UV)。SH组共149次,RH组146次,比较两组各项指标的变化并分析各参数间的关系。结果SH组各小时RBV的变化均明显大于RH组(P<0.01)。SH组总的UV明显大于RH组。用体表面积校正后,UV分别为(2122.5±560.20)和(1389.83±615.59)ml/m2,P<0.01。用UV对RBV进行校正,RBV的变化在SH组仍明显大于RH组[分别为(-6.10±3.15),(-11.44±4.34),(15.62±5.30),(-18.83±7.43)%和(-2.94±3.23),(-6.91+4.99),(-11.04±5.82),(-14.87±6.16)%,P均<0.01]。RH组中有2例增加超滤量,干体重下降后,其平均动脉压(0h,1-3h)显著下降。RH组有58次在透后1h内RBV较开始时升高。结论在血透中,SH和RH患者间RBV的变化存在差异,这可能部分与两组患者的水化状态不同有关。对于SH患者,当RBV变化较大时要警惕发生低血压;对RH患者,当发现RBV变化较小时应当注意是否仍然存在水负荷过多。进一步降低原先认为已达临床估计目标的干体重值可能使部分RH患者血压得到进一步下降。 展开更多
关键词 症状性低血压 血容量变化 高血压患者 血液透析 难治性高血压 RBV 平均动脉压 水负荷过多 体表面积 体重下降 水化状态 患者血压 临床估计 超滤量 RH SH 透析后 透析前 监测仪 UV 干体重 血透 校正
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BATE curve in assessment of clinical utility of predictive biomarkers 被引量:2
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作者 ZHOU XiaoHua 1,2,3,& MA YunBei 4,5 1 Northwest HSR&D Center of Excellence,VA Puget Sound Health Care System,Seattle,WA 98198,USA 2 Department of Biostatistics,University of Washington,Seattle,WA 98198,USA +2 位作者 3 Beijing International Center for Mathematical Research,Peking University,Beijing 100871,China 4 Department of Operations Research and Financial Engineering,Princeton University,Princeton,NJ 08540,USA 5 School of Statisitcs,Southwest University of Finance and Economics,Chengdu 611130,China 《Science China Mathematics》 SCIE 2012年第8期1529-1552,共24页
In this paper, for time-to-event data, we propose a new statistical framework for casual inference in evaluating clinical utility of predictive biomarkers and in selecting an optimal treatment for a particular patient... In this paper, for time-to-event data, we propose a new statistical framework for casual inference in evaluating clinical utility of predictive biomarkers and in selecting an optimal treatment for a particular patient. This new casual framework is based on a new concept, called Biomarker Adjusted Treatment Effect (BATE) curve. The BATE curve can be used for assessing clinical utility of a predictive biomarker, for designing a subsequent confirmation trial, and for guiding clinical practice. We then propose semi-p^rametric methods for estimating the BATE curves of biomarkers and establish asymptotic results of the proposed estimators for the BATE curves. We also conduct extensive simulation studies to evaluate finite-sample properties of the proposed estimation methods. Finally, we illustrate the application of the proposed method in a real-world data set. 展开更多
关键词 predictive biomarker cutoff points INTERACTION BATE curve time-to-event outcome
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