This report studied on pharmaceutical characteristics of the stealth liposome containing dau-norubicin (DNR). The shape, size, entrapment efficiency and stability of the daunorubicin stealth liposomes (DNRSL) were exa...This report studied on pharmaceutical characteristics of the stealth liposome containing dau-norubicin (DNR). The shape, size, entrapment efficiency and stability of the daunorubicin stealth liposomes (DNRSL) were examined. Visible spectrophotometry and the HPLC method were established for determination of the DNR in the DNRSL. The release of DNR from DNRSL in HBS (pH 7.5) and rat serum at 37 oC were examined. The results showed that the DNRSL had high entrapment efficiency (>85%), small size and slow release.展开更多
Sorafenib,a multitargeted tyrosine kinase inhibitor,has been shown to improve survival in patients with advanced hepatocellular carcinoma(HCC).As the clinical use of sorafenib increases,many adverse effects have been ...Sorafenib,a multitargeted tyrosine kinase inhibitor,has been shown to improve survival in patients with advanced hepatocellular carcinoma(HCC).As the clinical use of sorafenib increases,many adverse effects have been reported,such as hand-foot skin reaction,diarrhea,anorexia,asthenia,alopecia,weight loss,hypertension and arterial thromboembolism.However,there are no prior reports of splenic infarction as an adverse effect of sorafenib.Here,a case of splenic infarction in a patient with HCC who was treated with sorafenib is reported. The patient had no other predisposing factors to explain the splenic infarction except for the administration of sorafenib.The splenic infarction improved after sorafenib was discontinued;however,the HCC progressed.展开更多
According to the aplanatism theory, lens can be used to focus the electromagnetic wave. A piano-convex hyperboloid of revo- lution lens made of low loss material is designed for combinatorial applications with the rec...According to the aplanatism theory, lens can be used to focus the electromagnetic wave. A piano-convex hyperboloid of revo- lution lens made of low loss material is designed for combinatorial applications with the rectangle microstrip applicator in microwave hyperthermia. Results of the extensive simulations and experiments show that the introduction of the lens to the clinical used antenna can significantly improve the directivity and hence increase the microwave power density in near field. In microwave hyperthermia applications, the lens antenna will exhibit superior directivity, high gain and well thermal efficiency for tumor in superficial layer. Besides, it has small treatment area that is helpful for reducing the injury of the normal tissue around the tumor.展开更多
文摘This report studied on pharmaceutical characteristics of the stealth liposome containing dau-norubicin (DNR). The shape, size, entrapment efficiency and stability of the daunorubicin stealth liposomes (DNRSL) were examined. Visible spectrophotometry and the HPLC method were established for determination of the DNR in the DNRSL. The release of DNR from DNRSL in HBS (pH 7.5) and rat serum at 37 oC were examined. The results showed that the DNRSL had high entrapment efficiency (>85%), small size and slow release.
文摘Sorafenib,a multitargeted tyrosine kinase inhibitor,has been shown to improve survival in patients with advanced hepatocellular carcinoma(HCC).As the clinical use of sorafenib increases,many adverse effects have been reported,such as hand-foot skin reaction,diarrhea,anorexia,asthenia,alopecia,weight loss,hypertension and arterial thromboembolism.However,there are no prior reports of splenic infarction as an adverse effect of sorafenib.Here,a case of splenic infarction in a patient with HCC who was treated with sorafenib is reported. The patient had no other predisposing factors to explain the splenic infarction except for the administration of sorafenib.The splenic infarction improved after sorafenib was discontinued;however,the HCC progressed.
文摘According to the aplanatism theory, lens can be used to focus the electromagnetic wave. A piano-convex hyperboloid of revo- lution lens made of low loss material is designed for combinatorial applications with the rectangle microstrip applicator in microwave hyperthermia. Results of the extensive simulations and experiments show that the introduction of the lens to the clinical used antenna can significantly improve the directivity and hence increase the microwave power density in near field. In microwave hyperthermia applications, the lens antenna will exhibit superior directivity, high gain and well thermal efficiency for tumor in superficial layer. Besides, it has small treatment area that is helpful for reducing the injury of the normal tissue around the tumor.
