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《外科免疫学》
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作者 Zbar AndrewP 于健春 《国外医学情报》 2003年第5期46-47,共2页
关键词 《外科免疫学》 抗肿瘤免疫疗法 临床免疫抑制 创伤 脓肿 移植学 粘膜免疫
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Effect of perioperative blood transfusion on clinical outcomes in hepatic surgery for cancer 被引量:10
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作者 Gianlorenzo Dionigi Luigi Boni +5 位作者 Francesca Rovera Stefano Rausei Salvatore Cuffari Giovanni Cantone Alessandro Bacuzzi Renzo Dionigi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第32期3976-3983,共8页
Allogeneic blood transfusion during liver resection for malignancies has been associated with an increased incidence of different types of complications: infectious complications, tumor recurrence, decreased survival.... Allogeneic blood transfusion during liver resection for malignancies has been associated with an increased incidence of different types of complications: infectious complications, tumor recurrence, decreased survival. Even if there is clear evidence of transfusion-induced immunosuppression, it is difficult to demonstrate that transfusion is the only determinant factor that decisively affects the outcome. In any case there are several motivations to reduce the practice of blood transfusion. The advantages and drawbacks of different transfusion alternatives are reviewed here, emphasizing that surgeons and anesthetists who practice in centers with a high volume of liver resections, should be familiar with all the possible alternatives. 展开更多
关键词 Blood transfusion Blood products Allogeneicblood transfusion Intraoperative autotransfusion Preoperative autologous blood donation Intraoperativeisovolemic hemodilution Infectious complications Liverresection Hepatocellular carcinoma
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Transplantation in autoimmune liver diseases 被引量:4
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作者 Marcus Mottershead James Neuberger 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第21期3388-3395,共8页
Liver transplantation remains an effective treatment for those with end-stage disease and with intractable liver-related symptoms.The shortage of organs for transplantation has resulted in the need for rationing.A var... Liver transplantation remains an effective treatment for those with end-stage disease and with intractable liver-related symptoms.The shortage of organs for transplantation has resulted in the need for rationing.A variety of approaches to selection and allocation have been developed and vary from country to country.The shortage of donors has meant that new approaches have to be adopted to make maximal use of the available organs;these include splitting grafts,use of extended criteria livers,livers from non-heart-beating donors and from living donors.Post transplantation,most patients will need life-long immunosuppression,although a small proportion can have immunosuppression successfully withdrawn.Newer immunosuppressive drugs and different strategies may allow a more targeted approach with a reduction in side-effects and so improve the patient and graft survival.For autoimmune diseases,transplantation is associated with significant improvement in the quality and length of life.Disease may recur after transplantation and may affect patient and graft survival. 展开更多
关键词 Liver transplantation Autoimmune disease RECURRENCE IMMUNOSUPPRESSION
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Present and future cell therapies for pancreatic beta cell replenishment 被引量:3
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作者 Juan Domínguez-Bendala Camillo Ricordi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第47期6876-6884,共9页
If only at a small scale,islet transplantation has successfully addressed what ought to be the primary endpoint of any cell therapy:the functional replenishment of damaged tissue in patients.After years of less-thanop... If only at a small scale,islet transplantation has successfully addressed what ought to be the primary endpoint of any cell therapy:the functional replenishment of damaged tissue in patients.After years of less-thanoptimal approaches to immunosuppression,recent advances consistently yield long-term graft survival rates comparable to those of whole pancreas transplantation.Limited organ availability is the main hurdle that stands in the way of the widespread clinical utilization of this pioneering intervention.Progress in stem cell research over the past decade,coupled with our decades-long experience with islet transplantation,is shaping the future of cell therapies for the treatment of diabetes.Here we review the most promising avenues of research aimed at generating an inexhaustible supply of insulin-producing cells for islet regeneration,including the differentiation of pluripotent and multipotent stem cells of embryonic and adult origin along the beta cell lineage and the direct reprogramming of non-endocrine tissues into insulin-producing cells. 展开更多
关键词 Human embryonic stem cells Induced pluripotent stem cells Mesenchymal stem cells Beta cell differentiation REPROGRAMMING Islet transplantation
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Orthotopic heart transplantation with prolonged donor ischemic time:report of 3 cases and literature review
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作者 Zhang Zaigao Xie Shuiben Xue Zhiqiang Bei Yajun Zhao Zhe 《Journal of Medical Colleges of PLA(China)》 CAS 2009年第4期235-238,共4页
Heart transplantation has become an effective therapy for patients with end stage heart failure. The preservation of the donor heart is an important factor that affects the results of the operation. We performed 3 cas... Heart transplantation has become an effective therapy for patients with end stage heart failure. The preservation of the donor heart is an important factor that affects the results of the operation. We performed 3 cases of orthotopic heart transplantation and obtained some experience in the preservation of the donor heart. Methods: Three male patients with end stage heart failure received the operation in our department successfully. Doppler echocardiography showed left ventrieular end diameter (LVED) of the patients were 91, 87, and 83 mm, and ejection fraction (EF) were 24%, 20%, 12.9%, respectively. Once the declaration of brain death had been made, the median stemotomy was performed with a sternal saw. Haparin at a dose of 300 U/kg of body weight was administered. After at least 2-min heparin circulation, the procurement proceeded. The superior vena cava and the inferior vena cava were nearly completely divided. When the heart was empty, the ascending aorta was cross-clamped and the St. Thomas solution was infused by gravity. The heart was excised by transection of the inferior vena cava, the superior vena cava and all pulmonary veins. After donor heart was removed, it was infused with University of Wisconsin (UW) solution by gravity at a temperature of 4-6℃, then placed in UW solution for storage during transportation. The temperature of solution was maintained at about 4-6℃. The ischemic times of donor heart were 9, 8 and 6 h, respectively. The bicaval anastomotic heart transplantation was adopted. The left atrial anastomoses were constructed using 3.0 polypropylene. The inferior vene cava anastomosis was constructed, the donor and native aorta were cut to an appropriate length. Then the aorta and main pulmonary artery anastomosis were performed respectively. The superior vene cava anastomosis was usually constructed during the rewarming phase. The intraoperative course with a cardiopulmonary bypass of the 3 patients was 96, 44 and 49 min, respectively. Standard triple immunosuppression therapy was commenced in the immediate post-operative period. Results: The operation procedure was smooth and no perioperative death occurred. The follow-up was carried out carefully. The patient's condition was fine in 25, 30 and 32 months after operation. The blood pressure was 130/90, 140/95 and 120/80 mmHg, respectively, and LVED was 51, 49 and 53 mm; EF was 50%, 54% and 60%, respectively. Cardiothoracic ratio was 0.63, 0.55, and 0.64, respectively. Conclusion: Preservation time of donor heart with St. Thomas solution infusion and UW solution storage at 0-4℃ may exceed 6 h, and receive comparable middle-term outcomes. 展开更多
关键词 Heart transplantation Dilated cardiomyopathy Myocardial protection Donor heart preservation
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举办朝阳移植论坛通知
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《中华器官移植杂志》 CAS CSCD 北大核心 2010年第4期226-226,共1页
朝阳移植论坛为中华医学会继续教育项目。论坛特别约请国内外著名移植专家进行专题讲座,追踪器官移植领域国际最新进展,力求从深层次探讨器官移植基础和临床问题。论坛安排较多讨论时间,让与会者能与国内外专家面对面互动交流。本次... 朝阳移植论坛为中华医学会继续教育项目。论坛特别约请国内外著名移植专家进行专题讲座,追踪器官移植领域国际最新进展,力求从深层次探讨器官移植基础和临床问题。论坛安排较多讨论时间,让与会者能与国内外专家面对面互动交流。本次论坛主题为于细胞移植疗法诱导移植免疫耐受、胰岛细胞移植和临床免疫抑制药物监测。与会人员可授予国家级I类继续医学教育学分6分。欢迎全国器官移植相关专业医技人员和临床药物分析药技人员参加。 展开更多
关键词 器官移植 论坛 继续教育项目 移植免疫耐受 细胞移植疗法 临床免疫抑制 胰岛细胞移植 继续医学教育
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举办朝阳移植论坛通知
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《中华器官移植杂志》 CAS CSCD 北大核心 2010年第6期331-331,共1页
朝阳移植论坛为中华医学会继续教育项目。论坛特别约请国内外著名移植专家进行专题讲座,追踪器官移植领域国际最新进展,力求从深层次探讨器官移植基础和临床问题。论坛安排较多讨论时间,让与会者能与国内外专家面对面互动交流。本次... 朝阳移植论坛为中华医学会继续教育项目。论坛特别约请国内外著名移植专家进行专题讲座,追踪器官移植领域国际最新进展,力求从深层次探讨器官移植基础和临床问题。论坛安排较多讨论时间,让与会者能与国内外专家面对面互动交流。本次论坛主题为干细胞移植疗法诱导移植免疫耐受、胰岛细胞移植和临床免疫抑制药物监测。与会人员可授予国家级I类继续医学教育学分6分。欢迎全国器官移植相关专业医技人员和临床药物分析药技人员参加。 展开更多
关键词 器官移植 论坛 继续教育项目 移植免疫耐受 细胞移植疗法 临床免疫抑制 胰岛细胞移植 继续医学教育
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举办朝阳移植论坛通知
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《中华器官移植杂志》 CAS CSCD 北大核心 2010年第7期428-428,共1页
朝阳移植论坛为中华医学会继续教育项目。论坛特别约请国内外著名移植专家进行专题讲座,追踪器官移植领域国际最新进展,力求从深层次探讨器官移植基础和临床问题。论坛安排较多讨论时间,让与会者能与国内外专家面对面互动交流。本次... 朝阳移植论坛为中华医学会继续教育项目。论坛特别约请国内外著名移植专家进行专题讲座,追踪器官移植领域国际最新进展,力求从深层次探讨器官移植基础和临床问题。论坛安排较多讨论时间,让与会者能与国内外专家面对面互动交流。本次论坛主题为干细胞移植疗法诱导移植免疫耐受、胰岛细胞移植和临床免疫抑制药物监测。与会人员可授予国家级Ⅰ类继续医学教育学分6分。欢迎全国器官移植相关专业医技人员和临床药物分析药技人员参加。 展开更多
关键词 器官移植 论坛 继续教育项目 移植免疫耐受 细胞移植疗法 临床免疫抑制 胰岛细胞移植 继续医学教育
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Effect of soothing-liver and nourishing-heart acupuncture on early selective serotonin reuptake inhibitor treatment onset for depressive disorder and related indicators of neuroimmunology:a randomized controlled clinical trial 被引量:15
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作者 Liu Yi Feng Hui +6 位作者 Mo Yali Gao Jingfang Mao Hongjing Song Mingfen Wang Shengdong Yin Yan Liu Wenjuan 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2015年第5期507-513,共7页
OBJECTIVE:To observe the effect of soothing-liver and nourishing-heart acupuncture on selective serotonin reuptake inhibitor(SSRIs) treatment effect onset in patients with depressive disorder and related indicators of... OBJECTIVE:To observe the effect of soothing-liver and nourishing-heart acupuncture on selective serotonin reuptake inhibitor(SSRIs) treatment effect onset in patients with depressive disorder and related indicators of neuroimmunology.METHODS:Overall,126 patients with depressive disorder were randomly divided into a medicine and acupuncture-medicine group using a random number table.Patients were treated for 6 consecutive weeks.The two groups were evaluated by the Montgomery-Asberg Depression Rating Scale(MADRS) and Side Effects Rating Scale(SERS) to assess the effect of the soothing-liver and nourishing-heart acupuncture method on early onset of SSRI treatment effect.Changes in serum 5-hydroxytryptamine(5-HT) and inflammatory cytokines before and after treatment were recorded and compared between the medicine group and the acupuncture-medicine group.RESULTS:The acupuncture-medicine group had significantly lower MADRS scores at weeks 1,2,4,and 6 after treatment compared with the medicine group(P < 0.01).The acupuncture group had significantly lower SERS scores at weeks 1,2,4,and 6 after treatment compared with the medicine group(P < 0.01).At 6 weeks after treatment,serum 5-HT in the acupuncture-medicine group was significantly higher compared with the medicine group(P <0.01).lnterleukin-6(IL-6) in the acupuncture-medicine group was significantly lower than that in the medicine group(P < 0.01),whereas there was no significant difference in IL-1(3 between the groups(P > 0.05).Anti-inflammatory cytokines IL-4 and IL-10 were significantly higher in the acupuncture-medicine group compared with the medicine group(P < 0.01,P < 0.05,respectively).CONCLUSION:The soothing-liver and nourishing-heart acupuncture method can effectively accelerate the onset of SSRI effects when treating depressive disorder and can significantly reduce the adverse reactions of SSRIs.Moreover,acupuncture can enhance serum 5-HT and regulate the balance of pro-inflammatory cytokines and anti-inflammatory cytokines. 展开更多
关键词 Acupuncture Soothing-liver and nourishing-heart method Early onset Serotonin uptake inhibitors Depressive disorder Serotonin Inflammatory cytokines Randomized controlled trial
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