目的采用临床证据实践应用系统(JBI-PACES)应用于外周静脉留置针操作,观察其对输液的成功率及常见并发症的影响。方法 2017年3—8月该院收治的住院患儿100例,根据护理方法不同分为观察组与对照组各50例。对照组采用常规护理模式,观察组...目的采用临床证据实践应用系统(JBI-PACES)应用于外周静脉留置针操作,观察其对输液的成功率及常见并发症的影响。方法 2017年3—8月该院收治的住院患儿100例,根据护理方法不同分为观察组与对照组各50例。对照组采用常规护理模式,观察组采用JBI-PACES中搜集临床推荐的相关静脉留置针护理证据,加以应用并对留置针并发症进行及时处理。比较两组一次性穿刺成功情况、输液速度及并发症发生情况。结果观察组一次性穿刺成功率88.0%高于对照组的70.0%,并发症发生率16.0%低于对照组的38.0%,两组输液速度接近。结论采用J B I-P A C E S中A级证据应用并规范化操作,可提高外周静脉留置针的一次性穿刺成功率,降低并发症发生率。展开更多
Angiotensin （Ang）-（1-7） is recognized as a new bioactive peptide in renin-angiotensin system （RAS）. Ang-（1-7） is a counter-regulatory mediator of Ang-II which appears to be protective against cardiovascular di...Angiotensin （Ang）-（1-7） is recognized as a new bioactive peptide in renin-angiotensin system （RAS）. Ang-（1-7） is a counter-regulatory mediator of Ang-II which appears to be protective against cardiovascular disease. Recent studies have found that Ang-（1-7） played an important role in reducing smooth muscle cell proliferation and migration, improving endothelial function and regulating lipid metabolism, leading to inhibition of atherosclerotic lesions and increase of plaque stability. Although clinical application of Ang-（1-7） is restricted due to its pharmacokinetic properties, identification of stabilized compounds, including more stable analogues and specific delivery compounds, has enabled clinical application of Ang-（1-7）. In this review, we discussed recent findings concerning the biological role of Ang-（1-7） and related mechanism during atherosclerosis development. In addition, we highlighted the perspective to develop therapeutic strategies using Ang-（1-7） to treat atherosclerosis.展开更多
Objective: To explore the feasibility and effect of anterior cervical decompression and fusion under METRx system. Methods: Between Nov. 2001 and Nov. 2003, totally 23 consecutive patients were performed anterior cerv...Objective: To explore the feasibility and effect of anterior cervical decompression and fusion under METRx system. Methods: Between Nov. 2001 and Nov. 2003, totally 23 consecutive patients were performed anterior cervical decompression and fusion under METRx system. The clinical outcome was evaluated by Odom standard. Results: Decompression and fusion along with internal fixation was obtained in all the 23 patients with minimal tissue damage and operation-caused scar. There were no wound infection, neurological injuries, throat discomfort and other complications. The total rate of excellent and good outcome in patients with degenerative cervical diseases was 94%. Conclusion: Cervical decompression and fusion can be performed under METRx system with its own advantages, such as minimal tissue damage and operation-caused scar, less throat discomfort.展开更多
Introducing the development background and essential aspects of Betty Newman's system model,and exploring the application status of the theory all over the worldwide.This review points out that combining the theor...Introducing the development background and essential aspects of Betty Newman's system model,and exploring the application status of the theory all over the worldwide.This review points out that combining the theoretical model with nursing practice can effectively improve patients'disease self-management ability and improve the quality of life.At the same time,the theory has certain similarities with traditional Chinese medicine nursing,and can provide reference for the development of Chinese medicine nursing theory.展开更多
There has been unprecedented progress in the development of biomedical nanotechnology and nanoma- terials over the past few decades, and nanoparticle-based drug delivery systems （DDSs） have great potential for clin-...There has been unprecedented progress in the development of biomedical nanotechnology and nanoma- terials over the past few decades, and nanoparticle-based drug delivery systems （DDSs） have great potential for clin- ical applications. Among these, magnetic drug delivery systems （MDDSs） based on magnetic nanoparticles （MNPs） are attracting increasing attention owing to their favor- able biocompatibility and excellent multifunctional loading capability. MDDSs primarily have a solid core of super paramagnetic maghemite （y-Fe^03） or magnetite （Fe304） nanoparticles ranging in size from 10 to 100nm. Their surface can be functionalized by organic and/or inorganic modification. Further conjugation with targeting ligands, drug loading, and MNP assembly can provide complex magnetic delivery systems with improved targeting efficacy and reduced toxicity. Owing to their sensitive response to external magnetic fields, MNPs and their assemblies have been developed as novel smart delivery systems. In this review, we first summarize the basic physicochemical and magnetic properties of desirable MDDSs that fulfill the requirements for specific clinical applications. Secondly, we discuss the surface modifications and functionalization issues that arise when designing elaborate MDDSs for future clinical uses. Finally, we highlight recent progress in the design and fabrication of MNPs, magnetic assemblies, and magnetic microbnbbles and liposomes as MDDSs for cancer diagnosis and therapy. Recently, researchers have focused on enhanced targeting efficacy and theranostics by applying step-by-step sequential treatment, and by magnetically mod- ulating dosing regimens, which are the current challenges for clinical applications.展开更多
文摘目的采用临床证据实践应用系统(JBI-PACES)应用于外周静脉留置针操作,观察其对输液的成功率及常见并发症的影响。方法 2017年3—8月该院收治的住院患儿100例,根据护理方法不同分为观察组与对照组各50例。对照组采用常规护理模式,观察组采用JBI-PACES中搜集临床推荐的相关静脉留置针护理证据,加以应用并对留置针并发症进行及时处理。比较两组一次性穿刺成功情况、输液速度及并发症发生情况。结果观察组一次性穿刺成功率88.0%高于对照组的70.0%,并发症发生率16.0%低于对照组的38.0%,两组输液速度接近。结论采用J B I-P A C E S中A级证据应用并规范化操作,可提高外周静脉留置针的一次性穿刺成功率,降低并发症发生率。
基金This work was supported by National Natural Science Foundation of China （NSFC） （No. 81400265 and No. 81270274）, and Peking University People＇s Hospital Research and Development funds （RDB2014-16）.
文摘Angiotensin （Ang）-（1-7） is recognized as a new bioactive peptide in renin-angiotensin system （RAS）. Ang-（1-7） is a counter-regulatory mediator of Ang-II which appears to be protective against cardiovascular disease. Recent studies have found that Ang-（1-7） played an important role in reducing smooth muscle cell proliferation and migration, improving endothelial function and regulating lipid metabolism, leading to inhibition of atherosclerotic lesions and increase of plaque stability. Although clinical application of Ang-（1-7） is restricted due to its pharmacokinetic properties, identification of stabilized compounds, including more stable analogues and specific delivery compounds, has enabled clinical application of Ang-（1-7）. In this review, we discussed recent findings concerning the biological role of Ang-（1-7） and related mechanism during atherosclerosis development. In addition, we highlighted the perspective to develop therapeutic strategies using Ang-（1-7） to treat atherosclerosis.
文摘Objective: To explore the feasibility and effect of anterior cervical decompression and fusion under METRx system. Methods: Between Nov. 2001 and Nov. 2003, totally 23 consecutive patients were performed anterior cervical decompression and fusion under METRx system. The clinical outcome was evaluated by Odom standard. Results: Decompression and fusion along with internal fixation was obtained in all the 23 patients with minimal tissue damage and operation-caused scar. There were no wound infection, neurological injuries, throat discomfort and other complications. The total rate of excellent and good outcome in patients with degenerative cervical diseases was 94%. Conclusion: Cervical decompression and fusion can be performed under METRx system with its own advantages, such as minimal tissue damage and operation-caused scar, less throat discomfort.
文摘Introducing the development background and essential aspects of Betty Newman's system model,and exploring the application status of the theory all over the worldwide.This review points out that combining the theoretical model with nursing practice can effectively improve patients'disease self-management ability and improve the quality of life.At the same time,the theory has certain similarities with traditional Chinese medicine nursing,and can provide reference for the development of Chinese medicine nursing theory.
基金financially funded by the National Natural Science Foundation of China (NSFC, 31370019, 61420106012)the project of National Key Basic Research Program of China (2013CB733804)+1 种基金The funding partially comes from the Fundamental Research Funds for the Central Universities (2242016K41072)Zhong Ying Young Scholar of Southeast University as well as the support fromthe Collaborative Innovation Center of Suzhou Nano Science and Technology
文摘There has been unprecedented progress in the development of biomedical nanotechnology and nanoma- terials over the past few decades, and nanoparticle-based drug delivery systems （DDSs） have great potential for clin- ical applications. Among these, magnetic drug delivery systems （MDDSs） based on magnetic nanoparticles （MNPs） are attracting increasing attention owing to their favor- able biocompatibility and excellent multifunctional loading capability. MDDSs primarily have a solid core of super paramagnetic maghemite （y-Fe^03） or magnetite （Fe304） nanoparticles ranging in size from 10 to 100nm. Their surface can be functionalized by organic and/or inorganic modification. Further conjugation with targeting ligands, drug loading, and MNP assembly can provide complex magnetic delivery systems with improved targeting efficacy and reduced toxicity. Owing to their sensitive response to external magnetic fields, MNPs and their assemblies have been developed as novel smart delivery systems. In this review, we first summarize the basic physicochemical and magnetic properties of desirable MDDSs that fulfill the requirements for specific clinical applications. Secondly, we discuss the surface modifications and functionalization issues that arise when designing elaborate MDDSs for future clinical uses. Finally, we highlight recent progress in the design and fabrication of MNPs, magnetic assemblies, and magnetic microbnbbles and liposomes as MDDSs for cancer diagnosis and therapy. Recently, researchers have focused on enhanced targeting efficacy and theranostics by applying step-by-step sequential treatment, and by magnetically mod- ulating dosing regimens, which are the current challenges for clinical applications.
