Circulating tumor cells(CTCs) are tumor cells that enter the blood circulation after detaching from the primary tumor and can migrate to reach distant organs, where they can give rise to aggressive metastasis. Clinica...Circulating tumor cells(CTCs) are tumor cells that enter the blood circulation after detaching from the primary tumor and can migrate to reach distant organs, where they can give rise to aggressive metastasis. Clinical studies have revealed that the presence of CTCs in peripheral blood is correlated with disease progression in lung cancer. However, as CTCs are rare cancer cells released from tumors into the bloodstream, both enrichment and sensitive detection methods are technically challenging. In order to best understand how CTCs are currently being deployed, this review mainly focuses on the different detection methods for CTCs. Furthermore, we will describe the clinical impact of circulating tumor cells in lung cancer and discuss their potential use as biomarker to guide the prognosis.展开更多
四川大学华西医院实验医学科是于2002年底在医院的统一规划下整和了全院的临床检测实验室后成立的临床检测中心，下设8个临床检测专业实验室及一个前处理组。为了对实验医学科的工作实行标准化质量管理，提升临床检测的服务质量并建立...四川大学华西医院实验医学科是于2002年底在医院的统一规划下整和了全院的临床检测实验室后成立的临床检测中心，下设8个临床检测专业实验室及一个前处理组。为了对实验医学科的工作实行标准化质量管理，提升临床检测的服务质量并建立科学的临床实验室质量管理体系，在医院领导全方位的大力支撑与美国中华医学基金会（china medical board，CMB）“临床实验室认可”课题的资助下，于2003年初在全科启动了美国病理学家学会（college of american pathologist，CAP）的实验室认可计划（laboratory accreditation program，LAP）.展开更多
基金Supported by grants from the Natural Science Foundation of Heilongjiang Province(No.H201335)Development Center for Medical Science and Technology,Ministry of Health,China(No.W2012FZ105)
文摘Circulating tumor cells(CTCs) are tumor cells that enter the blood circulation after detaching from the primary tumor and can migrate to reach distant organs, where they can give rise to aggressive metastasis. Clinical studies have revealed that the presence of CTCs in peripheral blood is correlated with disease progression in lung cancer. However, as CTCs are rare cancer cells released from tumors into the bloodstream, both enrichment and sensitive detection methods are technically challenging. In order to best understand how CTCs are currently being deployed, this review mainly focuses on the different detection methods for CTCs. Furthermore, we will describe the clinical impact of circulating tumor cells in lung cancer and discuss their potential use as biomarker to guide the prognosis.
文摘四川大学华西医院实验医学科是于2002年底在医院的统一规划下整和了全院的临床检测实验室后成立的临床检测中心，下设8个临床检测专业实验室及一个前处理组。为了对实验医学科的工作实行标准化质量管理，提升临床检测的服务质量并建立科学的临床实验室质量管理体系，在医院领导全方位的大力支撑与美国中华医学基金会（china medical board，CMB）“临床实验室认可”课题的资助下，于2003年初在全科启动了美国病理学家学会（college of american pathologist，CAP）的实验室认可计划（laboratory accreditation program，LAP）.
