AIM:To evaluate the impact of feeding colicky infants with an adapted formula on the hydrogen breath test and clinical symptoms.METHODS:Hydrogen expiration was measured by SC MicroLyzer gas chromatography at inclusion...AIM:To evaluate the impact of feeding colicky infants with an adapted formula on the hydrogen breath test and clinical symptoms.METHODS:Hydrogen expiration was measured by SC MicroLyzer gas chromatography at inclusion and 15 d after treatment with an adapted low-lactose formula in 20 colicky infants.RESULTS:All babies were symptomatic:85% with excess gas,75% with abnormal feeding pattern,and 85% with excessive crying.The hydrogen breath test at inclusion was abnormal:35 ± 3.1 ppm.After 15 d feeding with an adapted low-lactose formula,crying and flatulence decreased in 85% of patients (P < 0.001).For infants in whom no decrease of gas was reported,crying was still reduced (P < 0.01).Moreover,the feeding pattern was improved in 50% of infants when it was initially considered as abnormal.Finally,the hydrogen breath test decreased significantly (10 ± 2.5 ppm,P < 0.01).CONCLUSION:This study showed an association between clinical improvement and evidence of decreased levels of hydrogen when the infants were fed with a specially designed,low-lactose formula.展开更多
基金Supported by United Pharmaceuticals SAS,55 Avenue Hoche,75008 Paris,France
文摘AIM:To evaluate the impact of feeding colicky infants with an adapted formula on the hydrogen breath test and clinical symptoms.METHODS:Hydrogen expiration was measured by SC MicroLyzer gas chromatography at inclusion and 15 d after treatment with an adapted low-lactose formula in 20 colicky infants.RESULTS:All babies were symptomatic:85% with excess gas,75% with abnormal feeding pattern,and 85% with excessive crying.The hydrogen breath test at inclusion was abnormal:35 ± 3.1 ppm.After 15 d feeding with an adapted low-lactose formula,crying and flatulence decreased in 85% of patients (P < 0.001).For infants in whom no decrease of gas was reported,crying was still reduced (P < 0.01).Moreover,the feeding pattern was improved in 50% of infants when it was initially considered as abnormal.Finally,the hydrogen breath test decreased significantly (10 ± 2.5 ppm,P < 0.01).CONCLUSION:This study showed an association between clinical improvement and evidence of decreased levels of hydrogen when the infants were fed with a specially designed,low-lactose formula.
