The recent clinical curative effect and adverse events of docetaxel and capecitabine (DX) of neo- adjuvant chemotherapy in patients with locally advanced breast cancer was discussed. Methods: The data of 72 cases o...The recent clinical curative effect and adverse events of docetaxel and capecitabine (DX) of neo- adjuvant chemotherapy in patients with locally advanced breast cancer was discussed. Methods: The data of 72 cases of neoadjuvant chemotherapy (DX) in locally advanced breast cancer after 4 cycles were retrospectively analyzed. Docetaxel 75 mg/m^2 by infusion 1 h on dl, capecitabine 2000 mg/m^2 by oral for twice daily on d1-14, 21 days was a cycle. Results: All 72 patients were assessed for efficacy and adverse events. The total effective rate was 80.5% (58/72), including pathological complete response (pCR) was 7 (9.7%), clinical complete remission (cCR) was 15(20.8%), clinical partial response (PR) was 43 (59.7%), stable disease (SD) was 8 (11.1%) and progressive disease (PD) was 6 (8.3%). The main adverse events were gastrointestinal reactions and bone marrow suppression. The 3 to 4 degrees of adverse reactions including granulocytopenia in 7 patients (20.6%), hand-foot syndrome in 6 patients (15.2%). Conclusion: The DX regimen provide a favorable efficacy and safety profile in patients with locally advanced breast cancer for neoadjuvant chemotherapy.展开更多
Objective: To observe the clinical effect of mild moxibustion plus acupoint injection for optic atrophy. Methods: Ninety-four patients with optic atrophy were divided into a treatment group (51 cases) and a contr...Objective: To observe the clinical effect of mild moxibustion plus acupoint injection for optic atrophy. Methods: Ninety-four patients with optic atrophy were divided into a treatment group (51 cases) and a control group (43 cases). The treatment group was treated with mild moxibustion plus acupoint injection, and the control group was treated with medications. After three courses, the change of vision was observed. Results: The total effective rate was 82.4% in the treatment group and 41.9% in the control group, with a statistical difference between the two groups (P〈O.05). Conclusion: Moxibustion plus acupoint injection is an effective method to treat optic atrophy.展开更多
Objective: To observe the clinical effects of the Hua Tuo Manual Acupuncture Therapeutic Stimulator for peripheral facial paralysis. Methods: 87 patients with peripheral facial paralysis were divided randomly into the...Objective: To observe the clinical effects of the Hua Tuo Manual Acupuncture Therapeutic Stimulator for peripheral facial paralysis. Methods: 87 patients with peripheral facial paralysis were divided randomly into the SXDZ-100 Nerve and Muscle Stimulator treatment group (44 cases) and the G6805 Electric Stimulator control group (43 cases). The acupoints selected for both the two groups were local points as well as distal points as Hegu (LI 4), Waiguan (TE 5), Sanyinjiao (SP 6), Taichong (LR 3). Effectiveness was compared between the two groups. Results: Both groups had a total effective rate of 100%. But the cure rate was 90.9% in the treatment group, and 73.0% in the control group, indicating a significant difference (P<0.05). No side effects were found in either of the two groups. Conclusion: The SXDZ-100 stimulator is more effective than the G6805 electroacupuncture stimulator for treatment of peripheral facial paralysis.展开更多
基金Supported by grants from the Sub-Topics of Major Drug Discovery platform in the Twelfth-Five Year Research Program of China(No.2012ZX09303016-002)the Liaoning Province Science & Technology Development Funds(No.2012225019)
文摘The recent clinical curative effect and adverse events of docetaxel and capecitabine (DX) of neo- adjuvant chemotherapy in patients with locally advanced breast cancer was discussed. Methods: The data of 72 cases of neoadjuvant chemotherapy (DX) in locally advanced breast cancer after 4 cycles were retrospectively analyzed. Docetaxel 75 mg/m^2 by infusion 1 h on dl, capecitabine 2000 mg/m^2 by oral for twice daily on d1-14, 21 days was a cycle. Results: All 72 patients were assessed for efficacy and adverse events. The total effective rate was 80.5% (58/72), including pathological complete response (pCR) was 7 (9.7%), clinical complete remission (cCR) was 15(20.8%), clinical partial response (PR) was 43 (59.7%), stable disease (SD) was 8 (11.1%) and progressive disease (PD) was 6 (8.3%). The main adverse events were gastrointestinal reactions and bone marrow suppression. The 3 to 4 degrees of adverse reactions including granulocytopenia in 7 patients (20.6%), hand-foot syndrome in 6 patients (15.2%). Conclusion: The DX regimen provide a favorable efficacy and safety profile in patients with locally advanced breast cancer for neoadjuvant chemotherapy.
基金supported by Taihe Hospital Affiliated to Hubei Medical College
文摘Objective: To observe the clinical effect of mild moxibustion plus acupoint injection for optic atrophy. Methods: Ninety-four patients with optic atrophy were divided into a treatment group (51 cases) and a control group (43 cases). The treatment group was treated with mild moxibustion plus acupoint injection, and the control group was treated with medications. After three courses, the change of vision was observed. Results: The total effective rate was 82.4% in the treatment group and 41.9% in the control group, with a statistical difference between the two groups (P〈O.05). Conclusion: Moxibustion plus acupoint injection is an effective method to treat optic atrophy.
文摘Objective: To observe the clinical effects of the Hua Tuo Manual Acupuncture Therapeutic Stimulator for peripheral facial paralysis. Methods: 87 patients with peripheral facial paralysis were divided randomly into the SXDZ-100 Nerve and Muscle Stimulator treatment group (44 cases) and the G6805 Electric Stimulator control group (43 cases). The acupoints selected for both the two groups were local points as well as distal points as Hegu (LI 4), Waiguan (TE 5), Sanyinjiao (SP 6), Taichong (LR 3). Effectiveness was compared between the two groups. Results: Both groups had a total effective rate of 100%. But the cure rate was 90.9% in the treatment group, and 73.0% in the control group, indicating a significant difference (P<0.05). No side effects were found in either of the two groups. Conclusion: The SXDZ-100 stimulator is more effective than the G6805 electroacupuncture stimulator for treatment of peripheral facial paralysis.