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BRAF突变与甲状腺乳头状癌临床病理学特征关系研究 被引量:1
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作者 王培顺 李淑琴 +4 位作者 王岩 汪瑞 高希涛 王昭昕 周军 《岭南现代临床外科》 2022年第2期134-137,142,共5页
目的 探讨BRAF基因在甲状腺乳头状癌(PTC)中的突变率,及其与临床病理学特征的关系。方法 选取2018年1月至2019年12月经手术治疗的253例甲状腺乳头状癌患者作为研究对象,分析BRAF基因突变与甲状腺乳头状癌患者临床病理学特征的关系。结果... 目的 探讨BRAF基因在甲状腺乳头状癌(PTC)中的突变率,及其与临床病理学特征的关系。方法 选取2018年1月至2019年12月经手术治疗的253例甲状腺乳头状癌患者作为研究对象,分析BRAF基因突变与甲状腺乳头状癌患者临床病理学特征的关系。结果 81%的PTC患者中发现有BRAF基因的突变。BRAF突变率随着年龄的增长而增加,BRAF突变与PTC的淋巴转移以及临床分期间比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示年龄≥45岁、高肿瘤分期、区域淋巴结转移是BRAF突变的独立影响因素(均P<0.05)。结论 BRAF基因突变与PTC淋巴结转移、临床分期相关,而且对于甲状腺肿瘤良恶性的诊断具有重要价值。 展开更多
关键词 甲状腺乳头状癌 BRAF 突变 临床病理性特征
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Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion 被引量:9
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作者 Jing Zhao Xiang-Dong Luo Chun-Li Da Yan Xin 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第17期2145-2150,共6页
AIM: To explore the relation between B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) expression and the clinicopathological features of gastric carcinoma (GC).METHODS: Immunohistochemistry... AIM: To explore the relation between B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) expression and the clinicopathological features of gastric carcinoma (GC).METHODS: Immunohistochemistry was used to detect the expression of Bmi-1 and ki-67. Doublelabeling staining was used to display the distribution of Bcl-2^+/ki-67 cells in 162 cases of GC and its matched normal mucosa and precancerous lesion.RESULTS: The positive rate of Bmi-1 expression in GC(52.5%) was significantly higher than that in normal gastric mucosa (21.6%, X^2 = 33.088, P 〈 0.05). The Bmi-1 expression in GC was closely related with the Lauren's and Borrmann's classification and clinicalstage (X^2 = 4.400, 6.122 and 11.190, respectively, P〈 0.05). The expression of ki-67 was related to the Borrmann's classification (X^2 = 13.380, P 〈 0.05).Bcl-2 expression was correlated with the Lauren's classification (Z2 = 4.725, P 〈 0.05), and the Bmi-1 expression both in GC (rk = 0.157, P 〈 0.05) and inintestinal metaplasia (rk = 0.270, P 〈 0.05).CONCLUSION: Abnormal Bmi-1 expression in GCmay be involved in cell proliferation, apoptosis andcancerization. This marker can objectively indicate theclinicopathological characteristics of GC. 展开更多
关键词 B-cell-specific Moloney murine leukemiavirus insertion site 1 Gastric carcinoma Precancerouslesion Cell proliferation Apoptosis
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Comethylation of p16 and MGMT genes in colorectal carcinoma:Correlation with clinicopathological features and prognostic value 被引量:10
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作者 Koviljka Krtolica Milena Krajnovic +3 位作者 Slavica Usaj-Knezevic Dragan Babic Dusan Jovanovic Bogomir Dimitrijevic 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第8期1187-1194,共8页
AIM: To investigate the significance of p16 and O6- methylguanine-DNA methyltransferase (MGMT) genes promoter hypermethylation and K-ras mutations on colorectal tumorigenesis and progression. METHODS: p16 and MGMT met... AIM: To investigate the significance of p16 and O6- methylguanine-DNA methyltransferase (MGMT) genes promoter hypermethylation and K-ras mutations on colorectal tumorigenesis and progression. METHODS: p16 and MGMT methylation status was examined on 47 tumor samples, and K-ras mutational status was examined on 85 tumor samples. For methylation analysis, a methylation specific PCR (MS-PCR) method was used. RESULTS: p16 and MGMT promoter methylation was found in 51% (24/47) and 43% (20/47) of CRCs, respectively, and the K-ras mutation was found in 44% (37/85) of CRCs. Comethylation of p16 and MGMT genes was significantly associated with lower aggressiveness of the disease within a two-year period of observation. Only 27% of patients with simultaneous p 16 and MGMT methylation showed the detectible occurrence of metastasis and/or death, compared to 67% of patients without double methylation or with no methylation (3/11 vs 22/33, P < 0.05, χ2-test). In addition, p16 and MGMT comethylation showed a trend toward an association with longer survival in patients with CRCs (35.5 ± 6.0 mo vs 23.1 ± 3.2 mo, P = 0.072, Log-rank test). Progression of the disease within a two-year period was observed in 66% of patients carrying the K-ras mutation, compared to only 19% of patients with wild type K-ras (29/44 vs 7/37, P < 0.001, χ2-test). The presence of the K-ras mutation significantly correlated to shortened overall survival (20.0 ± 1.9 mo vs 37.0 ± 1.8 mo, P < 0.001, Log-rank test). The comethylation of p16 and MGMT genes was significantly associated with lower aggressiveness of the disease even when K-ras mutations were included in the analysis as an independent variable. CONCLUSION: Our data suggest that comethylation of promoters of p 16 and MGMT genes could have a prognostic value in patients with CRC. Specifically, concurrent methylation of both genes correlates with better prognosis. 展开更多
关键词 Colorectal carcinoma DNA methylation P16 MGMT K-ras mutation
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Multifocal stenosing ulceration of the small intestine 被引量:5
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作者 Hugh James Freeman 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第39期4883-4885,共3页
Several reports have described an apparently uncommon clinicopathological disorder that is characterized by multifocal stenosing small-intestinal ulceration.Compared to Crohn's disease,the ulcers are not transmura... Several reports have described an apparently uncommon clinicopathological disorder that is characterized by multifocal stenosing small-intestinal ulceration.Compared to Crohn's disease,the ulcers are not transmural and typically remain shallow,and involve only the mucosa and submucosa.The disorder seems to be localized in the jejunum and proximal ileum only,and not the distal ileum or colon.Only nonspecif ic inflammatory changes are present without giant cells or other typical features of granulomatous inflammation.Most patients present clinically with recurrent obstructive events that usually respond to steroids,surgical resection,or both.With the development of newer imaging modalities to visualize the small-intestinal mucosa,such as double-balloon enteroscopy,improved understanding of the long-term natural history of this apparently distinctive disorder should emerge. 展开更多
关键词 ULCER STENOSIS Intestinal diseases Small intestine Crohn's disease
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Clinicopathologic characteristics and prognostic factors of 63 gastric cancer patients with metachronous ovarian metastasis 被引量:3
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作者 Qiang Feng Wei Pei +2 位作者 Zhao-Xu Zheng Jian-Jun Bi Xing-Hua Yuan 《Cancer Biology & Medicine》 SCIE CAS CSCD 2013年第2期86-91,共6页
Objective: This study aims to explore the clinicopathologic characteristics and prognostic factors of gastric cancer patients with metachronous ovarian metastasis. Methods: Clinicopathologic data were collected from... Objective: This study aims to explore the clinicopathologic characteristics and prognostic factors of gastric cancer patients with metachronous ovarian metastasis. Methods: Clinicopathologic data were collected from 63 post-operative gastric cancer patients with metachronous ovarian metastasis. The patients were admitted to the Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College between January 1999 and December 2011. A log-rank test was conducted for survival analysis. Possible prognostic factors that affect survival were examined by univariate analysis. A Cox regression model was used for multivariate analysis. Results: The incidence of ovarian metastasis was 3.4% with a mean age of 45 years. Up to 65.1% of the patients were pre- menopausal. The mean interval between ovarian metastasis and primary cancer was 16 months. Lowly differentiated carcinoma ranked first in the primary gastric cancers. The majority of lesions occurred in the serous membrane (87.3%). The metastatic sites included Nz.3 lymph nodes (68.3%), bilateral ovaries (85.7%), and peritoneal membrane (73%). Total resection of metastatic sites was performed (31.7%). The overall median survival was 13.6 months, whereas the overall 1-, 2-, and 3-year survival rates were 52.5%, 22.0%, and 9.8%, respectively. The 5-year survival rate was zero. Univariate analysis showed that the patient prognosis was correlated with metastatic peritoneal seeding, vascular tumor embolus, range of lesion excision, and mode of comprehensive treatment with adjuvant chemotherapy (P〈0.05). Multivariate analysis indicated that metastatic peritoneal seeding was an independent prognostic factor for gastric cancer patients with ovarian metastasis (P〈0.01). Conclusion: Effective control of peritoneal seeding--induced metastasis is important for improving the prognosis of gastric cancer patients with ovarian metastasis. 展开更多
关键词 Gastric neoplasms OVARY METASTASIS PROGNOSIS
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Sclerosing cholangitis associated with autoimmune pancreatitis differs from primary sclerosing cholangitis 被引量:9
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作者 Terumi Kamisawa Kensuke Takuma +4 位作者 Hajime Anjiki Naoto Egawa Masanao Kurata Goro Honda Kouji Tsuruta 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第19期2357-2360,共4页
AIM:To clarify the characteristic features of biliary le-sions in patients with autoimmune pancreatitis(AIP) and compare them with those of primary sclerosing cholangitis(PSC) .METHODS:The clinicopathological characte... AIM:To clarify the characteristic features of biliary le-sions in patients with autoimmune pancreatitis(AIP) and compare them with those of primary sclerosing cholangitis(PSC) .METHODS:The clinicopathological characteristics of 34 patients with sclerosing cholangitis(SC) associated with AIP were compared with those of 4 patients with PSC.RESULTS:SC with AIP occurred predominantly in el-derly men.Obstructive jaundice was the most frequent initial symptom in SC with AIP.Only SC patients with AIP had elevated serum IgG4 levels,and sclerosing diseases were more frequent in these patients.SC pa-tients with AIP responded well to steroid therapy.Seg-mental stenosis of the lower bile duct was observed only in SC patients with AIP,but a beaded and pruned-tree appearance was detected only in PSC patients.Dense infi ltration of IgG4-positive plasma cells was de-tected in the bile duct wall and the periportal area,as well as in the pancreas,of SC patients with AIP.CONCLUSION:SC with AIP is distinctly different from PSC.The two diseases can be discriminated based on cholangiopancreatographic findings and serum IgG4 levels. 展开更多
关键词 Autoimmune pancreatitis IGG4 Primarysclerosing cholangitis Sclerosing cholangitis
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Double Primary Cancers in Extragastric Sites with Gastric Cancer: Report of Six Cases and Literature Review 被引量:1
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作者 Tao Fan Yingjie Song Dongqiu Dai Junqing Chen Huimian Xu 《Clinical oncology and cancer researeh》 CAS CSCD 2009年第6期436-438,共3页
OBJECTIVE To explore the clinical features, pathologiccharacteristics and prognosis of double primary malignant tumorswith involvement of the stomach and an extragastric site.METHODS We reviewed the records of 496 pat... OBJECTIVE To explore the clinical features, pathologiccharacteristics and prognosis of double primary malignant tumorswith involvement of the stomach and an extragastric site.METHODS We reviewed the records of 496 patients whounderwent surgery for gastric cancer in our department fromJanuary 2004 to December 2006. Synchronous double primarycancer was defined as an extragastric cancer diagnosed within a6-month interval before the detection of gastric cancer; any gastriccancer metastasis to other areas of the body was excluded.RESULTS Synchronous and metachronous double primarycancers were identified in 1 and in 5 patients, respectively. Theextragastric sites of the primary tumors in patients with gastriccancer were esophagus in 1 case, right colon in 1, rectum in 1,breast in 2 and lung in 1. Following gastric surgery, 5 patientsdied (within 2 mon, 24 mon, 30 mon, 48 mon and 60 mon). Only 1patient has survived and remains disease free.CONCLUSION The prognosis of patients with gastric cancerand a second primary is relatively poor. It is necessary to performregular esophagogastroduodenoscopy (EGD) on patients whohave been diagnosed with extragastric cancer, regardless of theirsymptoms. 展开更多
关键词 gastric cancer digestive tract cancer doubleprimary cancers.
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CLINICAL AND PATHOLOGICAL MANIFESTATI-ONS OF PATIENTS WITH ANTINEUTROPHIL CYTO-PLASMIC AUTOANTIBODIES DIRECTED AGA INST PROTEINASE 3 OR MYELOPEROXIDASE 被引量:1
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作者 张? 董怡 +2 位作者 曾小峰 李永哲 唐福林 《Chinese Medical Sciences Journal》 CAS CSCD 2002年第1期32-35,共4页
To compare the clinical and pathological manifestations of patients with antineutrophil cytoplasmic autoantibodies (ANCA) directed against proteinas e 3 (anti PR3) or myeloperoxidase (anti MPO). Methods. One hundred a... To compare the clinical and pathological manifestations of patients with antineutrophil cytoplasmic autoantibodies (ANCA) directed against proteinas e 3 (anti PR3) or myeloperoxidase (anti MPO). Methods. One hundred and forty patients with ANCA were detected for anti PR3 a nd anti MPO by ELISA. The clinical features at presentation, histopathological characteristics and outcome of all patients who were tested positive for anti P R3 or anti MPO were analysed.Results. In anti PR3 group (n=21), 16 cases (76.2%) had systemic vasculitis , in which Wegener’s granulomatosis prevailed (13 cases, 61.9%). In anti MPO g roup (n=31), 19 cases (61.3%) were diagnosed as systemic vasculitis and 12 case s (38.7%) as microscopic angiitis. For vasculitic patients with anti PR3 and a nti MPO, the disease duration at diagnosis was 9.6±2.0m and 4.4±0.9m respecti vely, P< 0.05;vasculitis activity index (BVAS) and mean number of affected organ were 22.5±2.1, 5.0±0.4 and 25.1±1.7, 4.8±0.4 respectively, P >0.05;upper r espiratory tract, eye and joint involvements were 11(68.8%), 7(43.8%), 11(68.8 %) and 7(36.8%), 2(10.5%), 5(26.3%) respectively, P< 0.05.Although there was no statistical difference in renal involvement between these two groups, patien ts with serum creatine >500 μmol/L were more commonly seen in anti MPO group t han in anti PR3 group, which were 8(42.1%) and 2(12.5%) respectively, P< 0.05 . Ten relapses were seen in anti PR3 group and only 2 in anti MPO group, but t he acute mortality rate in anti MPO group (5/19, 27.4%) was much higher than t hat in anti PR3 group (1/16, 6.3%). Conclusions. Anti PR3 and anti MPO occurred mainly in systemic vasculitis. A large divergence was seen in the disease spectrum between patients with anti PR 3 and those with anti MPO. In particular, upper respiratory tract, eye and join t involvements, granuloma formation and relapse were more prominent in anti PR3 patients. By contrast, the anti MPO patients had a more acute disease onset, m ore rapid progressive renal involvement and a higher acute mortality rate. 展开更多
关键词 antineutrophil cytoplasmic autoantibodies MYELOPEROXIDASE proteina se 3
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Primary extraosseous Ewing's sarcoma of the lung in a 36-year-old female patient:clinical,imaging,and pathologic findings
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作者 Yafei Zhang Junming Feng +3 位作者 Zhiqiang Sun Jianfei Gao Bicheng Zhang Zhiguo Rao 《The Chinese-German Journal of Clinical Oncology》 CAS 2013年第11期555-558,共4页
Primary extraosseous Ewing's sarcoma is a very rare clinical entity. In the report, we present the case of a 36year-old female patient who underwent resection of lung mass and was diagnosed as having Ewing's s... Primary extraosseous Ewing's sarcoma is a very rare clinical entity. In the report, we present the case of a 36year-old female patient who underwent resection of lung mass and was diagnosed as having Ewing's sarcoma by pathological examination. The clinical, imaging, and pathologic features of the case are described and discussed. 展开更多
关键词 Ewing's sarcoma EXTRAOSSEOUS LUNG
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Clinicopathologic features and related prognosis factors analysis of the basal and non-basal phenotype of triple negative breast cancer
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作者 Lin Sun Lin Zhang Shasha Ren Deding Tao Yaqun Wu 《The Chinese-German Journal of Clinical Oncology》 CAS 2010年第5期249-252,共4页
Objective:Triple-negative breast cancer(estrogen receptor-negative,progesterone receptor-negative and Her2-negative) can be classified into two subtypes:basal and non-basal phenotype.And the basal phenotype is associa... Objective:Triple-negative breast cancer(estrogen receptor-negative,progesterone receptor-negative and Her2-negative) can be classified into two subtypes:basal and non-basal phenotype.And the basal phenotype is associated with poor outcome.The purpose of this study was to figure out the differences of clinicopathological characters and related factors of prognosis between these two subtypes.Methods:Immunohistochemical staining was performed for the CK5/6,CK17 basal markers and EGFR on biopsy samples from 40 triple-negative patients and the clinicopathology features of these samples were investigated.Results:Seventy percent of the patients were diagnosed as the basal phenotype.Compared with the non-basal phenotype,the basal phenotype lesions were significantly larger in diameter with a high nuclear grade.In the node-negative group the basal phenotype clearly showed the same clinicopathological differences.There was statistically significant concordance among all three antibodies.Conclusion:Expression of basal markers identifies a biologically and clinically distinct subgroup of TN tumors,justifying the use of basal markers to define the basal or the non-basal phenotype.It is important to help the doctor deciding the therapeutic strategy for patient with triple-negative breast cancer. 展开更多
关键词 breast cancer TRIPLE-NEGATIVE basal phenotype non-basal phenotype CLINICOPATHOLOGY PROGNOSIS
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Predictive biomarker and clinicopathological characteristics analysis for recurrence of early gastric cancer
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作者 Jiyuan Yang Zhiqiang Cai +3 位作者 Wei Du Junchuan Li Tingxuan Chen Yunhua Xu 《The Chinese-German Journal of Clinical Oncology》 CAS 2011年第7期394-398,共5页
Objective: The aim of this study was to identify the correlation between the clinicopathological characteristics and recurrence in early gastric cancer (EGC), what's more, we attempt to look for a predictive bioma... Objective: The aim of this study was to identify the correlation between the clinicopathological characteristics and recurrence in early gastric cancer (EGC), what's more, we attempt to look for a predictive biomarker to predict and treat for re-currence of EGC. Methods: This study retrospectively analyzed 178 early gastric cancer patients who had the complete post-operative and follow-up medical records in the First Affiliated Hospital of Yangtze University (China) between January 1995 to December 2005. All of them were followed-up to December 2009 regularly. Computer tomography (CT), endoscopy, and single photon emission computed tomography (SPET-CT) were used to diagnose for recurrence of EGC. Immunohistochem-istry (IHC) and fluorescence in situ hybridization (FISH) were used for the detection of cerbB2. Chi-square test was applied to this study for statistics analysis. Results: Fourteen patients had recurrence. Eighteen patients were cerbB2-positive, including twelve recurrence patients and six norecurrence patients. Sex, tumor depth, and lymph node metastasis were related to the recurrence of EGC. Also, cerbB2-positive patients had the higher recurrence rate compared to the cerbB2-negative patients. Conclusion: Recurrence of EGC after curative resection can be predicted by using some clinicopathological characteristics. CerbB2 can be used as a predictive biomarker for recurrence of EGC. 展开更多
关键词 early gastric cancer (EGC) RECURRENCE gene CERBB2 immunohistochemistry (IHC) fluorescence in situ hybridization (FISH)
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Analysis of clinicopathological and immunohistochemical features of 15 cases with olfactory neuroblastoma
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作者 Xianglan Ying Jun Lin Youping Yang 《The Chinese-German Journal of Clinical Oncology》 CAS 2009年第7期381-383,共3页
Objective:We studied the clinicopathological and immunohistochemical features of olfactory neuroblastoma(ONB).Methods:The clinic pathological data and immunohistochemical features of 15 cases with ONB were analyzed re... Objective:We studied the clinicopathological and immunohistochemical features of olfactory neuroblastoma(ONB).Methods:The clinic pathological data and immunohistochemical features of 15 cases with ONB were analyzed retrospectively,and the related literatures were reviewed.Results:The tumors were all located in the nasal cavity in 15 cases.According to Kadish's staging system,7 cases were in stage A,5 cases in stage B,and 3 cases in stage C.The morphological features showed small round or ovoid tumor cells divided into pieces or trabeculae by connective tissues which were rich in capillaries.The tumor cells had round or oval nuclei and fine chromatins and lack of cytoplasma.Flexner rosette and Homer-Wright rosette were found in some cases.Acidophilic fibrins were composed of cytoplasmic projection among tumor cells.All cases were positive for NSE,Syn,CgA,1 case was positive for Vimentin,2 cases were positive for S-100,while CKpan,LCA and HMB45 were all negative.Conclusion:ONB is a type of very rare malignant tumors,which could be diagnosed by pathology,and immunohistochemistry is helpful in the diagnosis and differential diagnosis. 展开更多
关键词 olfactory neuroblastoma (ONB) PATHOLOGY CLINIC IMMUNOHISTOCHEMISTRY
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Sacro-anterior haemangiopericytoma: a case report
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作者 Xiu-Hong Ge Shuai-Shuai Liu +2 位作者 Hu-Sheng Shan Zhi-Min Wang Qian-Wen Li 《Cancer Biology & Medicine》 SCIE CAS CSCD 2014年第2期139-143,共5页
Haemangiopericytoma(HPC) is a rare vascular tumor with borderline malignancy, considerable histological variability, and unpredictable clinical and biological behavior. HPC can present a diagnostic challenge because o... Haemangiopericytoma(HPC) is a rare vascular tumor with borderline malignancy, considerable histological variability, and unpredictable clinical and biological behavior. HPC can present a diagnostic challenge because of its indeterminate clinical, radiological, and pathological features. HPC generally presents in adulthood and is equally frequent in both sexes. HPC can arise in any site in the body as a slowly growing and painless mass. The precise cell type origin of HPC is uncertain. One third of HPCs occur in the head and neck areas. Exceptional cases of hemangioblastoma arising outside the head and neck areas have been reported, but little is known about their clinicopathologic and immunohistochemical features. This study reports on a case of a large sacro-anterior HPC in a 65-year-old male. 展开更多
关键词 Sacro-anterior haemangiopericytoma(HPC) soft tissue tumor
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