百安洗液联合硝呋太尔制霉素治疗霉菌性阴道炎的临床研究

目的探讨百安洗液联合硝呋太尔治疗霉菌性阴道炎的临床研究。方法选取2018年8月—2019年8月在平煤神马医疗集团总医院妇产科就诊的128例霉菌性阴道炎患者,随机分成对照组(64例)和治疗组(64例)。对照组患者外用硝呋太尔制霉素阴道软胶囊,于晚上临睡前清洗外阴后阴道给药,放入阴道后穹窿处,1粒/次,1次/d,连续外用7d。治疗组在对照组的基础上外用百安洗液,10 mL/次,2次/d,用温水稀释至100 mL冲洗阴道,连续使用7 d。观察两组患者临床疗效,比较两组临床症状治愈时间、血清氧化应激产物和血清炎性因子的变化情况。结果治疗后,治疗组总有效率96.88%显著高于对照组的76.56%(P<0.05)。治疗后,治疗组患者白带异常、外阴瘙痒、外阴阴道疼痛、黏膜充血等临床症状治愈时间均短于对照组(P<0.05)。治疗后,两组内皮素1(ET-1)、丙二醛(MDA)均显著降低,但一氧化氮(NO)、超氧化物歧化酶(SOD)显著升高(P<0.05);治疗后,治疗组患者ET-1、MDA指标均低于对照组,而NO、SOD指标均高于对照组(P<0.05)。治疗后,两组患者血清炎性因子白细胞介素4(IL-4)、白细胞介素6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)水平均显著降低(P<0.05);治疗后,治疗组这些血清炎性因子水平显著低于对照组(P<0.05)。结论百安洗液联合硝呋太尔治疗霉菌性阴道炎疗效显著,能明显改善相关临床症状和局部体征,有效降低氧化应激产物及炎症反应,临床应用安全有效,具有一定的临床推广应用价值。

Clinical Research on Zishengukang Pill(滋肾骨康丸)Used to Treat Delayed Union of Fracture

Objective:To observe the curative effect of Zishengukang Pill(滋肾骨康丸) on delayed union of fracture.Methods:Sixty-four patients with delayed union of fracture were randomly divided into a control group of 32 cases treated with Western medicine and a treatment group of 32 cases treated with Western medicine and Zishengukang Pill.After 3 courses of treatment with 30 days as a course,the curative effects in the two groups were evaluated and their clinical symptoms,union rate and union time of fracture were compared.Results:The treatment resulted in cure in 25 cases,improvement in 6 cases and ineffectiveness in 1 case with the effective rate at 96.8% in the treatment group,higher than 81.3% in the control group(P<0.05).The union rate of fracture in the treatment group was higher than that in the control group(34.3% vs.12.5%,P<0.05).The union time of fracture in the treatment group was shorter than that in the control group((4.0±1.7) months vs.(5.0±1.4) months,P<0.05).Conclusion:Zishengukang Pill with obvious curative effect in the treatment of delayed union of fracture is worth popularizing.