Objective: To investigate the ability of patients with myotonic dystrophy type 1 to recognise basic facial emotions. We also explored the relationship between facial emotion recognition, neuropsychological data, perso...Objective: To investigate the ability of patients with myotonic dystrophy type 1 to recognise basic facial emotions. We also explored the relationship between facial emotion recognition, neuropsychological data, personality, and CTG repeat expansion data in the DM-1 group. Methods: In total, 50 patients with DM-1 (28 women and 22 men) participated, with 41 healthy controls. Recognition of facial emotional expressions was assessed using photographs of basic emotions. A set of tests measured cognition and personality dimensions, and CTG repeat size was quantified in blood lymphocytes. Results: Patients with DM-1 showed impaired recognition of facial emotions compared with controls. A significant negative correlation was found between total score of emotion recognition in a forced choice task and CTG repeat size. Furthermore, specific cognitive functions (vocabulary, visuospatial construction ability, and speed) and personality dimensions (reward dependence and cooperativeness) correlated with scores on the forced choice emotion recognition task. Conclusion: These findings revealed a CTG repeat dependent facial emotion recognition deficit in the DM-1 group, which was associated with specific neuropsychological functions. Furthermore, a correlation was found between facial emotional recognition ability and personality dimensions associated with sociability. This adds a new clinically relevant dimension in the cognitive deficits associated with DM-1.展开更多
探究对小儿川崎病患者实施临床护理路径联合舒适护理干预的效果。方法 本次研究选取自2021年6月~2022年6月到我院就诊的86例小儿川崎病患者。以随机数字表法均分为联合组及路径组(n=43)。路径组行临床护理路径,联合组加用舒适护理干预,...探究对小儿川崎病患者实施临床护理路径联合舒适护理干预的效果。方法 本次研究选取自2021年6月~2022年6月到我院就诊的86例小儿川崎病患者。以随机数字表法均分为联合组及路径组(n=43)。路径组行临床护理路径,联合组加用舒适护理干预,比较两组的相关临床指标。结果 联合组相关临床指标中退热时间(2.41±1.26 vs 4.61±1.89)d、住院时间(6.96±1.31 vs 9.75±1.96)d及住院费用(2798.61±635.46 vs 3659.46±981.27)元均少于路径组,组间对比差异成立(P<0.05);两组干预前检验指标中白细胞计数(15.41±2.50 vs 15.33±2.67)×109/L以及C-反应蛋白水平(17.36±1.58 vs 17.21±1.49)mg/L对比均无统计学意义(P>0.05);干预后联合组检验指标中白细胞计数(8.44±1.39 vs 11.28±1.66)×109/L以及C-反应蛋白(3.22±1.08 vs 7.54±2.10)mg水平均低于路径组,组间对比差异成立(P<0.05);联合组家属护理满意程度(97.67 vs 83.72)%高于路径组,组间对比差异成立(P<0.05)。结论 临床护理路径联合舒适护理干预对小儿川崎病患者的应用效果较好,患者的相关临床指标改善,具有重要临床应用价值,建议进一步推广及应用。展开更多
文摘Objective: To investigate the ability of patients with myotonic dystrophy type 1 to recognise basic facial emotions. We also explored the relationship between facial emotion recognition, neuropsychological data, personality, and CTG repeat expansion data in the DM-1 group. Methods: In total, 50 patients with DM-1 (28 women and 22 men) participated, with 41 healthy controls. Recognition of facial emotional expressions was assessed using photographs of basic emotions. A set of tests measured cognition and personality dimensions, and CTG repeat size was quantified in blood lymphocytes. Results: Patients with DM-1 showed impaired recognition of facial emotions compared with controls. A significant negative correlation was found between total score of emotion recognition in a forced choice task and CTG repeat size. Furthermore, specific cognitive functions (vocabulary, visuospatial construction ability, and speed) and personality dimensions (reward dependence and cooperativeness) correlated with scores on the forced choice emotion recognition task. Conclusion: These findings revealed a CTG repeat dependent facial emotion recognition deficit in the DM-1 group, which was associated with specific neuropsychological functions. Furthermore, a correlation was found between facial emotional recognition ability and personality dimensions associated with sociability. This adds a new clinically relevant dimension in the cognitive deficits associated with DM-1.
文摘探究对小儿川崎病患者实施临床护理路径联合舒适护理干预的效果。方法 本次研究选取自2021年6月~2022年6月到我院就诊的86例小儿川崎病患者。以随机数字表法均分为联合组及路径组(n=43)。路径组行临床护理路径,联合组加用舒适护理干预,比较两组的相关临床指标。结果 联合组相关临床指标中退热时间(2.41±1.26 vs 4.61±1.89)d、住院时间(6.96±1.31 vs 9.75±1.96)d及住院费用(2798.61±635.46 vs 3659.46±981.27)元均少于路径组,组间对比差异成立(P<0.05);两组干预前检验指标中白细胞计数(15.41±2.50 vs 15.33±2.67)×109/L以及C-反应蛋白水平(17.36±1.58 vs 17.21±1.49)mg/L对比均无统计学意义(P>0.05);干预后联合组检验指标中白细胞计数(8.44±1.39 vs 11.28±1.66)×109/L以及C-反应蛋白(3.22±1.08 vs 7.54±2.10)mg水平均低于路径组,组间对比差异成立(P<0.05);联合组家属护理满意程度(97.67 vs 83.72)%高于路径组,组间对比差异成立(P<0.05)。结论 临床护理路径联合舒适护理干预对小儿川崎病患者的应用效果较好,患者的相关临床指标改善,具有重要临床应用价值,建议进一步推广及应用。