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基于术中CT自动配准的主动红外线光学导航系统精度影响因素分析
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作者 赵经纬 张蕴显 +3 位作者 刘亚军 范明星 刘波 田伟 《北京生物医学工程》 2023年第3期248-252,270,共6页
目的评估常见临床因素对术中基于CT自动配准的主动红外线光学导航系统临床精度的影响。方法在临床手术室环境下,以腰椎等比例Sawbone模型作为体模,采用标准手术体位和设备位置,以3D NAV导航系统的术中CT自动配准导航模式模拟临床导航操... 目的评估常见临床因素对术中基于CT自动配准的主动红外线光学导航系统临床精度的影响。方法在临床手术室环境下,以腰椎等比例Sawbone模型作为体模,采用标准手术体位和设备位置,以3D NAV导航系统的术中CT自动配准导航模式模拟临床导航操作验证多种临床因素对导航精度的影响。模型表面嵌入多枚钛合金标记珠,使用导航软件分别测量钛珠在CT图像中和导航系统中的坐标,计算坐标距离作为导航临床精度。然后在无影灯照射、手术床位姿、导航相机位姿三种临床因素下测量导航临床精度,并与初始状态的精度比较。结果初始状态导航临床精度为0.64 mm±0.30 mm;无影灯照射手术区后,导航临床精度为0.63 mm±0.25 mm;手术床降低10 cm和左倾15°时,导航临床精度分别为0.61 mm±0.21 mm和0.63 mm±0.21 mm;相机分别向左侧和向上旋转到示踪器恰好可见的位置时,导航临床精度分别为0.65 mm±0.30 mm和0.62 mm±0.21 mm;相机分别移动到距示踪器1 m和2 m的位置时,导航临床精度分别为0.64 mm±0.24 mm和0.67 mm±0.28 mm。在各因素影响下该导航系统的临床精度均与初始状态无显著性差异(n=108,P>0.05)。合并全部864次测量的导航临床精度为0.64 mm±0.25 mm。结论本研究中的导航系统临床精度不受无影灯照射、手术床位姿和导航相机位姿的影响。 展开更多
关键词 计算机辅助骨科手术 脊柱 主动红外线光学导航 临床精度 影响因素
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Neutron Capture Therapy (NCT) & In-Hospital Neutron Irradiator (IHNI)——a new technology on binary targeting radiation therapy of cancer 被引量:6
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作者 Zhou Yongmao 《Engineering Sciences》 EI 2009年第4期2-21,共20页
BNCT is finally becoming "a new option against cancer". The difficulties for its development progress of that firstly is to improve the performance of boron compounds, secondly, it is the requirements of quantificat... BNCT is finally becoming "a new option against cancer". The difficulties for its development progress of that firstly is to improve the performance of boron compounds, secondly, it is the requirements of quantification and accuracy upon radiation dosimetry evaluation in clinical trials. Furthermore, that is long anticipation on hospital base neutron sources. It includes dedicated new NCT reactor, accelerator based neutron sources, and isotope source facilities. In ad- dition to reactors, so far, the technology of other types of sources for clinical trials is not yet completely proven. The In- Hospital Neutron lrradiator specially designed for NCT, based on the MNSR successfully developed by China, can be installed inside or near the hospital and operated directly by doctors. The Irradiator has two neutron beams for respective treatment of the shallow and deep tumors. It is expected to initiate operation in the end of this year. It would provide a safe, low cost, and effective treatment tool for the NCT routine application in near future. 展开更多
关键词 Neutron Capture Therapy boron compound radiation dosimetry neutron beam in-hospital neutron irradi- ator
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Wiedemann-steiner综合征伴发育迟缓KMT2A基因变异分析一例
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作者 曹旭英 黄轲 崔岳崇 《实用妇科内分泌电子杂志》 2019年第35期114-116,共3页
目的对一例生长速度缓慢的女性患儿进行遗传学分析。方法使用高精度临床外显PLUS的检测方法对患儿、父亲和母亲同时进行,并进行一代和二代测序验证。结果检测到患者KMT2A基因杂合变异c.97629765delGATT(p.I3255Tfs*14),疑似新发突变。结... 目的对一例生长速度缓慢的女性患儿进行遗传学分析。方法使用高精度临床外显PLUS的检测方法对患儿、父亲和母亲同时进行,并进行一代和二代测序验证。结果检测到患者KMT2A基因杂合变异c.97629765delGATT(p.I3255Tfs*14),疑似新发突变。结论KMT2A基因杂合变异c.97629765delGATT(p.I3255Tfs*14)可能是患儿的遗传学病因。 展开更多
关键词 发育迟缓 KMT2A基因 精度临床外显PLUS检测
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An Accuracy Improvement for the Clinical Test Result by United ISO-GUM and QE
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作者 Yasuo Iwaki 《Computer Technology and Application》 2013年第1期6-16,共11页
This research developed the technology which united ISO-GUM (International Organization of Standard-Guide to Express of Uncertainty in Measurement) and QE (Quality Engineer) strategically and employed both feature... This research developed the technology which united ISO-GUM (International Organization of Standard-Guide to Express of Uncertainty in Measurement) and QE (Quality Engineer) strategically and employed both feature efficiently. Although to tow technology of purpose use is same, each has future. The purpose is scheduled to improve the accuracy as a result of the clinical examinations. The result of research was used for diagnosis by equivalent Quality Control (eqQC) of the same level when and where, that are needed for broader-based medical system of the time of IT-era. Since National Institute of Standard and Technology (NIST) is recommend use of complicated operation by ISO-GUM for uniting, realization required the newest high quality computer technology. The algorithm of the complexity system of operation is that Fast Fourier Transform (FFT), Inverse Fast Fourier Transform (IFFT) and Multi-variance Analysis (MA) are needed in Fig. 4. The main new improving points are changed of ambiguous expression method of data, and the pursuit which the cause of worsens accuracy put into data. All data with an assurance reported the final result for patient or donor. Medical laboratory quality system service is offered essential in the laboratory to be correct result for health care by Good Laboratory Practices (GLP) useful ISO 15189. Quality Assurance (QA) is achieved though system reliability. 展开更多
关键词 ISO-GUM (International Organization of Standard-Guide to Express of Uncertainty in Measurement) QE (QualityEngineer) IT-era clinical test QC (Quality Control) GLP (Good Laboratory Practices).
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