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俄语中医术语临床翻译中的运用 被引量:2
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作者 王丽莉 《天津中医药大学学报》 CAS 2009年第3期149-150,共2页
近年来,随着俄罗斯经济的复苏,中俄关系迈入正轨,世界性的医药“回归大自然”也波及到俄罗斯,中医凭着可靠的疗效得到了俄罗斯大众的青睐,俄罗斯国内对中医的需求也大幅增加。越来越多的俄罗斯学生来到中国,系统学习或者进修中医... 近年来,随着俄罗斯经济的复苏,中俄关系迈入正轨,世界性的医药“回归大自然”也波及到俄罗斯,中医凭着可靠的疗效得到了俄罗斯大众的青睐,俄罗斯国内对中医的需求也大幅增加。越来越多的俄罗斯学生来到中国,系统学习或者进修中医学知识。 展开更多
关键词 临床翻译 俄语 中医术语
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提高中医药临床翻译质量的方法研究
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作者 赵熔 衣素梅 +1 位作者 丁晓红 张旭 《南京中医药大学学报(社会科学版)》 2009年第3期175-,共1页
关键词 中医药 临床翻译 口译
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浅议如何做好中医药临床翻译工作
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作者 丁冲 《中国民族民间医药》 2011年第10期37-37,共1页
中医走向世界是我国振兴和发展中医的既定国策。要进一步弘扬、传播、普及中医药文化知识,推动中医药国际化,为人类的健康和发展做出更大贡献,必须依靠翻译这座桥梁。现今,随着中国的发展。
关键词 中医药 临床翻译
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外国留学生中医临床翻译实践
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作者 劳静 柴可夫 《中医教育》 2000年第3期62-62,共1页
关键词 中医 中医临床翻译 外国留学生 中医教育
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Detection of eukaryotic translation initiation factor 4E and its clinical significance in hepatocellular carcinoma 被引量:2
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作者 Xiao-Lin Wang Hong-Pei Cai +1 位作者 Jun-Hui Ge Xiao-Feng Su 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第20期2540-2544,共5页
AIM:To study the expression of eukaryotic translation initiation factor 4E(eIF4E),which is closely correlated with malignant tumors,and its relationship to prognosis in hepatocellular carcinoma. METHODS:Western blotti... AIM:To study the expression of eukaryotic translation initiation factor 4E(eIF4E),which is closely correlated with malignant tumors,and its relationship to prognosis in hepatocellular carcinoma. METHODS:Western blotting was performed to quantify the elF4E protein expression in the normal human liver cell line L02 and the hepatoma cell lines Hep3B, HepG2,and Huh7.Forty-six hepatocellular carcinoma samples with complete clinical data were obtained from Changzheng Hospital during the period of December 2008 to July 2009.The expression of eIF4E in the tumor samples and their adjacent tissues were detected by immunohistochemistry.The relationship between the test results and hepatocellular carcinoma(HCC) prognosis was statistically analysed by using a COX proportional hazard model. RESULTS:Western blotting analysis showed that there were distinct eIF4E protein bands in all three of the hepatoma cell lines.In particular,the HepG2 cell line had the highest level of eIF4E protein expression.The L02 cell group had a low eIF4E expression.Immunohistochemical assay showed that there were 32 cases in which the tumour tissue expression was higher than their adjacent tissues,accounting for 69.57%.There were also 14 cases in which the tumour tissue expression was lower or no significant difference was found, accounting for 30.43%.COX proportional hazards model analysis showed that HCC prognosis was related to the depth of invasion,the overexpression of eIF4E and p53, possibly as independent HCC prognostic predictors. CONCLUSION:In summary,eIF4E expression is associated with liver cancer,and patients with high eIF4E expression levels have a higher risk of recurrence. 展开更多
关键词 Hepatocellular carcinoma Eukaryotic translation initiation factor 4E Western blotting IMMUNOHISTOCHEMISTRY PROGNOSIS
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Pancreatic cancer:Translational research aspects and clinical implications 被引量:4
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作者 Daniel Ansari Bi-Cheng Chen +2 位作者 Lei Dong Meng-Tao Zhou Roland Andersson 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第13期1417-1424,共8页
Despite improvements in surgical techniques and adjuvant chemotherapy, the overall mortality rates in pan- creatic cancer have generally remained relatively un-changed and the 5-year survival rate is actually below 2%... Despite improvements in surgical techniques and adjuvant chemotherapy, the overall mortality rates in pan- creatic cancer have generally remained relatively un-changed and the 5-year survival rate is actually below 2%. This paper will address the importance of achieving an early diagnosis and identifying markers for prog- nosis and response to therapy such as genes, proteins, microP, NAs or epigenetic modifications. However, there are still major hurdles when translating investigational biomarkers into routine clinical practice. Furthermore, novel ways of secondary screening in high-risk individu- als, such as artificial neural networks and modern imaging, will be discussed. Drug resistance is ubiquitous in pancreatic cancer. Several mechanisms of drug resistance have already been revealed, including human equilibrative nucleoside transporter-1 status, multidrug resistance proteins, aberrant signaling pathways, mi-croRNAs, stromal influence, epithelial-mesenchymal transition-type cells and recently the presence of can- cer stem cells/cancer-initiating cells. These factors must be considered when developing more customized types of intervention ('personalized medicine'S. In the future, multifunctional nanoparticles that combine a specific targeting agent, an imaging probe, a cell-penetrating agent, a biocompatible polymer and an anti-cancer drug may become valuable for the management of pa- tients with pancreatic cancer. 展开更多
关键词 Pancreatic cancer Biomarkers IMAGING Artifi-cial neural networks Nanomedicine Personalized medicine
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Alcohol-induced protein hyperacetylation: Mechanisms and consequences 被引量:3
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作者 Blythe D Shepard Pamela L Tuma 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第10期1219-1230,共12页
Although the clinical manifestations of alcoholic liver disease are well-described, little is known about the molecular basis of liver injury. Recent studies have indicated that ethanol exposure induces global protein... Although the clinical manifestations of alcoholic liver disease are well-described, little is known about the molecular basis of liver injury. Recent studies have indicated that ethanol exposure induces global protein hyperacetylationo This reversible, post- translational modification on the E-amino groups of lysine residues has been shown to modulate multiple, diverse cellular processes ranging from transcriptional activation to microtubule stability. Thus, alcohol- induced protein hyperacetylation likely leads to major physiological consequences that contribute to alcohol-induced hepatotoxicity. Lysine acetylation is controlled by the activities of two opposing enzymes, histone acetyltransferases and histone deacetylases. Currently, efforts are aimed at determining which enzymes are responsible for the increased acetylation of specific substrates. However, the greater challenge will be to determine the physiological ramifications of protein hyperacetylation and how they might contribute to the progression of liver disease. In this review, we will first list and discuss the proteins known to be hyperacetylated in the presence of ethanol. We will then describe what is known about the mechanisms leading to increased protein acetylation and how hyperacetylation may perturb hepatic function. 展开更多
关键词 ETHANOL HEPATOTOXICITY ACETYLATION DEACETYLASES ACETYLTRANSFERASES
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Sumoylation of hypoxia inducible factor-1α and its significance in cancer 被引量:9
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作者 LI Jie XU Ying +3 位作者 JIAO HuiKe WANG Wei MEI Zhu CHEN GuoQiang 《Science China(Life Sciences)》 SCIE CAS 2014年第7期657-664,共8页
Hypoxia-inducible factor-1(HIF-1)is a key heterodimeric transcription factor for the cellular adaptive response to hypoxia,a common feature of the microenvironment in solid tumors.The transcriptional activity,protein ... Hypoxia-inducible factor-1(HIF-1)is a key heterodimeric transcription factor for the cellular adaptive response to hypoxia,a common feature of the microenvironment in solid tumors.The transcriptional activity,protein stabilization,protein-protein interactions and cellular localization of HIF-1α,an oxygen-sensitive subunit of HIF-1,are mainly modulated by various post-translational modifications.Recently,we reported that polycomb chromobox 4(Cbx4)governs the transcriptional activity of HIF-1αby enhancing its sumoylation at K391 and K477,through which Cbx4 potentiates angiogenesis of hepatocellular carcinoma.This review summarizes the current knowledge of HIF-1α sumoylation and its roles in the pathogenesis of cancer. 展开更多
关键词 HIF-1Α SUMOYLATION CANCER
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