[Objective] To study the preparation of Zipu Capsule and its clinical effect on the treatment of chronic periodontitis. [Method] The extraction, concentration, drying and preparation process of the raw herbal material...[Objective] To study the preparation of Zipu Capsule and its clinical effect on the treatment of chronic periodontitis. [Method] The extraction, concentration, drying and preparation process of the raw herbal materials for Zipu Capsule were selected out. And 60 cases of chronic periodontitis patients were randomly assigned to two groups and were treated with conventional therapy and nursing care, while the treatment group was added with taking the Zipu capsule, to compare the cura- tive effects of the two groups. [Result] Both of two groups showed decreases in gingival index (GO, periodontal pocket depth (PD) and attachment loss values (AL) after treatment, and those of the treatment group was significantly lower than those of the control group (P〈0.05). The total curative effective rate of the treatment group was 91.17%, and 76.92% in the control group, and the differences between the two groups reached the significant level (P〈0.05). [Conclusion] Zipu Capsule had definite therapeutic effect in treatment of chronic periodontitis and less adverse re- actions, which laid the foundation for the further development into drug products.展开更多
Objective To observe the therapeutic effect of electro acupuncture at QIǖXǖ(丘墟GB40) for treating migraine and provide clinical study for Acupoints Dictionary of People's Republic of China. Methods Multi-center ...Objective To observe the therapeutic effect of electro acupuncture at QIǖXǖ(丘墟GB40) for treating migraine and provide clinical study for Acupoints Dictionary of People's Republic of China. Methods Multi-center (3 First-Class hospitals) study was adopted, and the involved 3 hospitals did clinical observation according to the requirements of the project. The methods are as follows. All cases were randomized into treatment group and control group according to their sequence. QIǖXǖ(丘墟GB40) was selected in treatment group, while Tiānshū (天枢 ST25) was selected in control group. Both groups were performed electro acupuncture, and syndromes indexes of migraine and 5-HT were observed before and after treatment. All data were analyzed by statistic software SPSS11.5. Results There was significant difference of VAS margin between two groups in each center and the combined center (u= -3. 362, P=0. 001 ). There was significant difference of therapeutic effect of 4-week treatment between two groups in each clinical center and the combined center. The therapeutic effect of 3-month treatment between two groups in No. 1 and No. 3 hospitals, showed significant difference, the treatment group was better; while that of No. 2 hospital had no obvious difference. The therapeutic effect of 6-month treatment between two groups in each center and the combined center had significant difference, the treatment group was better. Conclusion The therapy of electro acupuncture at QIǖXǖ(丘墟GB40) is effective for migraine.展开更多
With the clinical manifestations and the point electric conduction volume as the indexes, the authors observed the immediate effects of the acupuncture treatment on chronic superficial gastritis with the points select...With the clinical manifestations and the point electric conduction volume as the indexes, the authors observed the immediate effects of the acupuncture treatment on chronic superficial gastritis with the points selected according to the date and time set by Ling Gui Ba Fa (灵龟八法 Eight Methods of Intelligent Turtle), which was compared with the effects in the control group treated with the points selected according to syndrome-differentiation. A higher symptom improvement rate (P<0.01) and a higher channel's balance-inverting rate were noticed in the former (P<0.01), indicating that Ling Gui Ba Fa can give a better therapeutic results.展开更多
According to the clinical experience of professor Shan Zhaowei (单兆伟), the author has successfully developed Qingyou Yangwei Capsule (清幽养胃胶囊capsules for eliminating pyrolic Helicobacterium and nourishing the s...According to the clinical experience of professor Shan Zhaowei (单兆伟), the author has successfully developed Qingyou Yangwei Capsule (清幽养胃胶囊capsules for eliminating pyrolic Helicobacterium and nourishing the stomach) for treating the gastritis. Clinical research has shown that the capsule has a good curative effect on chronic gastritis related to pyrolic Helicobacterium. Among the 53 cases in the treatment group, clinical observation showed cure in 6 cases, obvious effect in 18 cases, effect in 24 cases, no effect on 5 cases, with a total effective rate of 90.5%. Of the 50 cases in the control group, cure was found in 5 cases, obvious effect in 13 cases, effect in 20 cases, no effect in 12 cases, the total effective rate being 76%. The total effective rate in the treatment group was higher than that in the control group. The rate of eliminating pyrolic Helicobacterium in the treatment group was 66.04%, similar to that in the control group. In a follow-up visit 6 months later, the recurrence rate in the treatment group was 13.33%, obviously lower than that of 41.66% in the control group.展开更多
Objective: The aim of our study was to explore the short-term effects and complication of interleukin-2 (IL-2) combining with Cisplatin in the treatment of malignant hydrothorax.Methods: Sixty-two cases patients with ...Objective: The aim of our study was to explore the short-term effects and complication of interleukin-2 (IL-2) combining with Cisplatin in the treatment of malignant hydrothorax.Methods: Sixty-two cases patients with malignant hydrothorax were randomly divided into two groups.Observation group was 31 examples,thoracic cavity injection IL-2 and Cisplatin;31 cases in control group using Cisplatin alone intra-thoracic injection.The regime of every week for 1–4 weeks was used to observe short term effects and complications.Results: The total response rate in observe group was higher than that in control group (90.3% vs.68.1%),which had statistically significant difference (P < 0.05).The complications included gastrointestinal tract reaction,bone marrow inhibition,chest pain and fever.The incidence rates of chest pain and fever in observe group was slightly higher than that in control group,but there was no statistically significant difference (P > 0.05).Conclusion: The IL-2 combining with Cisplatin intra-thoracic injection for malignant hydrothorax has the features of good therapeutic effects and slight poisonous side effects,which is worth to be used in clinic.展开更多
Objective: The aim of our study was to observe the efficacy and toxicity of 50 cases of advanced non-small cell lung cancer (NSCLC) patients treated by pemetrexed. Methods: Fifty patients, including 29 females and...Objective: The aim of our study was to observe the efficacy and toxicity of 50 cases of advanced non-small cell lung cancer (NSCLC) patients treated by pemetrexed. Methods: Fifty patients, including 29 females and 21 males, with a median age 62 years (35–82 years), 13 of whom were treated with pemetrexed only and the left 37 cases were treated with pemetrexed combined with platinum in the Department of Oncology, Renmin Hospital of Wuhan University from June 2006 to March 2009. Single agent regimen: patients received pemetrexed 500 mg/m2 on day 1 with every 21 days. Combination regimen: patients received pemetrexed 500 mg/m2 on day 1 and carboplatin 300 mg/m2 on day 1 or cisplatin 35 mg/m2 on day 1 to day 3 or nedaplatin 80 mg/m2 on day 1 by intravenous infusion with 21 days as one cycle. RECIST 1.0 standard was used to evaluate the clinical efficiency, and the WHO toxicity standard was used to evaluate toxic reaction, and the QOL was used to evaluate the quality of life. Results: All patients were given 162 cycles (at least 2 cycles, at most 6 cycles) and the response rate of all the patients were evaluated. There were 2 complete remission (CR), 7 partial remission (PR), 22 stable disease (SD) and 19 progressive disease (PD) in the group, the overall response rate was (RR) was 18.0% and disease control rate (DCR) 62.0%. The quality of life improvement rate reaches 58.0%. The major toxic reaction included neutropenia, thrombocytopenia, hypemia, nausea, and vomiting. Most of the severity of these effects was grade I–II and well tolerated. Conclusion: Chemotherapy with pemetrexed or pemetrexed combined with platinum in the treatment of advanced non-small cell lung cancer is effective, safe and well-tolerable, which can improve quality of life of the patient.展开更多
基金Supported by the Approval Project of Guiyang University of Traditional Chinese Medicine(GTCM Nei[2014]24)
文摘[Objective] To study the preparation of Zipu Capsule and its clinical effect on the treatment of chronic periodontitis. [Method] The extraction, concentration, drying and preparation process of the raw herbal materials for Zipu Capsule were selected out. And 60 cases of chronic periodontitis patients were randomly assigned to two groups and were treated with conventional therapy and nursing care, while the treatment group was added with taking the Zipu capsule, to compare the cura- tive effects of the two groups. [Result] Both of two groups showed decreases in gingival index (GO, periodontal pocket depth (PD) and attachment loss values (AL) after treatment, and those of the treatment group was significantly lower than those of the control group (P〈0.05). The total curative effective rate of the treatment group was 91.17%, and 76.92% in the control group, and the differences between the two groups reached the significant level (P〈0.05). [Conclusion] Zipu Capsule had definite therapeutic effect in treatment of chronic periodontitis and less adverse re- actions, which laid the foundation for the further development into drug products.
文摘Objective To observe the therapeutic effect of electro acupuncture at QIǖXǖ(丘墟GB40) for treating migraine and provide clinical study for Acupoints Dictionary of People's Republic of China. Methods Multi-center (3 First-Class hospitals) study was adopted, and the involved 3 hospitals did clinical observation according to the requirements of the project. The methods are as follows. All cases were randomized into treatment group and control group according to their sequence. QIǖXǖ(丘墟GB40) was selected in treatment group, while Tiānshū (天枢 ST25) was selected in control group. Both groups were performed electro acupuncture, and syndromes indexes of migraine and 5-HT were observed before and after treatment. All data were analyzed by statistic software SPSS11.5. Results There was significant difference of VAS margin between two groups in each center and the combined center (u= -3. 362, P=0. 001 ). There was significant difference of therapeutic effect of 4-week treatment between two groups in each clinical center and the combined center. The therapeutic effect of 3-month treatment between two groups in No. 1 and No. 3 hospitals, showed significant difference, the treatment group was better; while that of No. 2 hospital had no obvious difference. The therapeutic effect of 6-month treatment between two groups in each center and the combined center had significant difference, the treatment group was better. Conclusion The therapy of electro acupuncture at QIǖXǖ(丘墟GB40) is effective for migraine.
文摘With the clinical manifestations and the point electric conduction volume as the indexes, the authors observed the immediate effects of the acupuncture treatment on chronic superficial gastritis with the points selected according to the date and time set by Ling Gui Ba Fa (灵龟八法 Eight Methods of Intelligent Turtle), which was compared with the effects in the control group treated with the points selected according to syndrome-differentiation. A higher symptom improvement rate (P<0.01) and a higher channel's balance-inverting rate were noticed in the former (P<0.01), indicating that Ling Gui Ba Fa can give a better therapeutic results.
文摘According to the clinical experience of professor Shan Zhaowei (单兆伟), the author has successfully developed Qingyou Yangwei Capsule (清幽养胃胶囊capsules for eliminating pyrolic Helicobacterium and nourishing the stomach) for treating the gastritis. Clinical research has shown that the capsule has a good curative effect on chronic gastritis related to pyrolic Helicobacterium. Among the 53 cases in the treatment group, clinical observation showed cure in 6 cases, obvious effect in 18 cases, effect in 24 cases, no effect on 5 cases, with a total effective rate of 90.5%. Of the 50 cases in the control group, cure was found in 5 cases, obvious effect in 13 cases, effect in 20 cases, no effect in 12 cases, the total effective rate being 76%. The total effective rate in the treatment group was higher than that in the control group. The rate of eliminating pyrolic Helicobacterium in the treatment group was 66.04%, similar to that in the control group. In a follow-up visit 6 months later, the recurrence rate in the treatment group was 13.33%, obviously lower than that of 41.66% in the control group.
文摘Objective: The aim of our study was to explore the short-term effects and complication of interleukin-2 (IL-2) combining with Cisplatin in the treatment of malignant hydrothorax.Methods: Sixty-two cases patients with malignant hydrothorax were randomly divided into two groups.Observation group was 31 examples,thoracic cavity injection IL-2 and Cisplatin;31 cases in control group using Cisplatin alone intra-thoracic injection.The regime of every week for 1–4 weeks was used to observe short term effects and complications.Results: The total response rate in observe group was higher than that in control group (90.3% vs.68.1%),which had statistically significant difference (P < 0.05).The complications included gastrointestinal tract reaction,bone marrow inhibition,chest pain and fever.The incidence rates of chest pain and fever in observe group was slightly higher than that in control group,but there was no statistically significant difference (P > 0.05).Conclusion: The IL-2 combining with Cisplatin intra-thoracic injection for malignant hydrothorax has the features of good therapeutic effects and slight poisonous side effects,which is worth to be used in clinic.
文摘Objective: The aim of our study was to observe the efficacy and toxicity of 50 cases of advanced non-small cell lung cancer (NSCLC) patients treated by pemetrexed. Methods: Fifty patients, including 29 females and 21 males, with a median age 62 years (35–82 years), 13 of whom were treated with pemetrexed only and the left 37 cases were treated with pemetrexed combined with platinum in the Department of Oncology, Renmin Hospital of Wuhan University from June 2006 to March 2009. Single agent regimen: patients received pemetrexed 500 mg/m2 on day 1 with every 21 days. Combination regimen: patients received pemetrexed 500 mg/m2 on day 1 and carboplatin 300 mg/m2 on day 1 or cisplatin 35 mg/m2 on day 1 to day 3 or nedaplatin 80 mg/m2 on day 1 by intravenous infusion with 21 days as one cycle. RECIST 1.0 standard was used to evaluate the clinical efficiency, and the WHO toxicity standard was used to evaluate toxic reaction, and the QOL was used to evaluate the quality of life. Results: All patients were given 162 cycles (at least 2 cycles, at most 6 cycles) and the response rate of all the patients were evaluated. There were 2 complete remission (CR), 7 partial remission (PR), 22 stable disease (SD) and 19 progressive disease (PD) in the group, the overall response rate was (RR) was 18.0% and disease control rate (DCR) 62.0%. The quality of life improvement rate reaches 58.0%. The major toxic reaction included neutropenia, thrombocytopenia, hypemia, nausea, and vomiting. Most of the severity of these effects was grade I–II and well tolerated. Conclusion: Chemotherapy with pemetrexed or pemetrexed combined with platinum in the treatment of advanced non-small cell lung cancer is effective, safe and well-tolerable, which can improve quality of life of the patient.