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新生儿窒息后心肌损害的临床诊断进展 被引量:4
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作者 陈成彩 钟秋红 梁玉美 《右江医学》 2019年第2期142-146,共5页
新生儿窒息是新生儿出生后一种比较危急和常见的疾病。新生儿窒息后心功能受到损害,心排出量减少,最后导致多器官损害及功能障碍[1]。心肌收缩和舒张功能障碍是心肌缺血缺氧/再灌注损伤的主要表现[2~3]。新生儿窒息后引起的心肌损害发... 新生儿窒息是新生儿出生后一种比较危急和常见的疾病。新生儿窒息后心功能受到损害,心排出量减少,最后导致多器官损害及功能障碍[1]。心肌收缩和舒张功能障碍是心肌缺血缺氧/再灌注损伤的主要表现[2~3]。新生儿窒息后引起的心肌损害发生概率为40%~70%[4]。因此,早期诊断新生儿窒息合并心肌损害的程度对有效地治疗患儿和提高预后,有着非常重要的临床意义。 展开更多
关键词 新生儿窒息 心肌损害 临床诊断进展
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Advances in the diagnosis and treatment of Ig G4-related sclerosing cholangitis: a review
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作者 Shunda Du Gang Liu Yilei Mao 《Oncology and Translational Medicine》 2015年第6期243-248,共6页
Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) is an IgG4-related disease characterized by bile duct fibroinflammatory wall-thickening and stenosis, resulting in obstruction jaundice, weight loss. Dif- f... Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) is an IgG4-related disease characterized by bile duct fibroinflammatory wall-thickening and stenosis, resulting in obstruction jaundice, weight loss. Dif- ferent regions of the bile duct can be involved, with the distal region being the most common. IgG4-SC can also have other organ involvement, such as the pancreas, urinary tract, salivary glands and lacrimal glands. In clinical practice, the manifestation of IgG4-SC is very similar to cholangiocarcinoma (CC) and primary sclerosing cholangiUs (PSC), as well as pancreatic malignancies, while the treatment and prognosis are totally different. Japanese researchers ever established the clinical diagnostic criteria in 2012: (1) charac- teristic biliary imaging findings; (2) elevated serum IgG4 concentrations; (3) the coexistence of IgG4-related diseases except those of the biliary tract; and (4) characteristic histopathological features. According to our observations, IgG4-SC can be distinguished from CC with 100% specificity only at a cutoff of six times the upper normal limit. Imaging findings have low specificity for diagnosis, with the exception of intraductal ultrasonography, which can reflect the lesion with relatively high specificity. IgG4 plasma cell infiltration can be found in bile duct biopsy tissue, although this procedure is difficult. According to recent studies, the treatment of IgG4-SC relies mainly on corticosteroids. Following steroid treatment, most IgG4-SC patients can recover and their symptoms are resolved although a few patients relapse after steroid withdrawal. Maintenance of steroid therapy or alternative drugs is necessary in such cases. There is, however, no stronq evidence for malignant transformation in I qG4-SC. 展开更多
关键词 Immunoglobulin G4 (IgG4) sclerosing cholangitis (SC) JAUNDICE intraductal ultrasonography steroid treatment
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