目的:分析和探讨支气管扩张症合并支气管哮喘的临床诊断和治疗效果。方法:选择于2013年1月~2014年1月接收的120例支气管扩张症合并支气管哮喘患者作为研究对象,按照抽签的方式将其随机分为对照组和观察组,对照组患者给予常规治疗,观...目的:分析和探讨支气管扩张症合并支气管哮喘的临床诊断和治疗效果。方法:选择于2013年1月~2014年1月接收的120例支气管扩张症合并支气管哮喘患者作为研究对象,按照抽签的方式将其随机分为对照组和观察组,对照组患者给予常规治疗,观察组在常规治疗的基础上给予必可酮雾化吸入治疗,然后对两组患者用力时的肺活量(forced vital capacity,FVC)、第1秒最大肺活量(Forced expiratory volume in one second,FEV1)、FEV1/FVC、峰值呼气流速(peak expiratory flow,PEF)值以及治疗效果进行记录和对比。结果:观察组患者的治疗有效率为98.33%,对照组的治疗有效率为91.67%,观察组的治疗有效率高于对照组(P〈0.05),FEV1、FVC、FEV1/FVC等指标高于对照组,其差异具有统计学意义(P〈0.05),而观察组患者的PEF与对照组比较差异无统计学意义(P〉0.05)。结论:对支气管扩张症合并支气管哮喘患者实施必可酮雾化吸入治疗,不仅可以提高患者的临床治疗效果,而且还能降低不良反应的发生率,因此值得在临床上推广。展开更多
Objective To evaluate prospectively the impact of fluorodeoxyglucose-fluorine-18 positron emission tomography (FDG-PET) in the detection of recurrence, second primary cancers, and distant metastases in head and neck s...Objective To evaluate prospectively the impact of fluorodeoxyglucose-fluorine-18 positron emission tomography (FDG-PET) in the detection of recurrence, second primary cancers, and distant metastases in head and neck squamous cell carcinoma (HNSCC) 6 months after treatment. Methods A total of 41 patients without any clinical element for recurrence, second primary cancer, or distant metastases received a whole-body FDG-PET as a routine surveillance tool 6 months after initial combined curative therapy for HNSCC. Results There were 35 negative PET results and 6 positive. One patient with abnormal FDG-PET did not have recurrent HNSCC (false positive). Five had true positive results: proven recurrence in 2 patients, second primary cancer in 2, and distant metastasis in 1. The sensitivity and specificity of FDG-PET for the diagnosis of HNSCC recurrence, second tumor, and distant metastases were 100% (5/5) and 97.2% (35/36), respectively. The positive predictive value was 83.3% (5/6). The negative predictive value was 100% (35/35). The overall accuracy was 97.6% (40/41). FDG-PET had a therapeutic impact in 5 of 41 patients (12.2%). There was no impact of FDG-PET on management in other 36 patients. Conclusion FDG-PET is useful as primary method for detecting nodal recurrence and distant metastases in HNSCC as well as second cancer in subclinical patients as it had a high effectiveness. But systematic FDG-PET performed at 6 months in patients without any clinical suspicion of local recurrence was scarcely useful.展开更多
文摘目的:分析和探讨支气管扩张症合并支气管哮喘的临床诊断和治疗效果。方法:选择于2013年1月~2014年1月接收的120例支气管扩张症合并支气管哮喘患者作为研究对象,按照抽签的方式将其随机分为对照组和观察组,对照组患者给予常规治疗,观察组在常规治疗的基础上给予必可酮雾化吸入治疗,然后对两组患者用力时的肺活量(forced vital capacity,FVC)、第1秒最大肺活量(Forced expiratory volume in one second,FEV1)、FEV1/FVC、峰值呼气流速(peak expiratory flow,PEF)值以及治疗效果进行记录和对比。结果:观察组患者的治疗有效率为98.33%,对照组的治疗有效率为91.67%,观察组的治疗有效率高于对照组(P〈0.05),FEV1、FVC、FEV1/FVC等指标高于对照组,其差异具有统计学意义(P〈0.05),而观察组患者的PEF与对照组比较差异无统计学意义(P〉0.05)。结论:对支气管扩张症合并支气管哮喘患者实施必可酮雾化吸入治疗,不仅可以提高患者的临床治疗效果,而且还能降低不良反应的发生率,因此值得在临床上推广。
文摘Objective To evaluate prospectively the impact of fluorodeoxyglucose-fluorine-18 positron emission tomography (FDG-PET) in the detection of recurrence, second primary cancers, and distant metastases in head and neck squamous cell carcinoma (HNSCC) 6 months after treatment. Methods A total of 41 patients without any clinical element for recurrence, second primary cancer, or distant metastases received a whole-body FDG-PET as a routine surveillance tool 6 months after initial combined curative therapy for HNSCC. Results There were 35 negative PET results and 6 positive. One patient with abnormal FDG-PET did not have recurrent HNSCC (false positive). Five had true positive results: proven recurrence in 2 patients, second primary cancer in 2, and distant metastasis in 1. The sensitivity and specificity of FDG-PET for the diagnosis of HNSCC recurrence, second tumor, and distant metastases were 100% (5/5) and 97.2% (35/36), respectively. The positive predictive value was 83.3% (5/6). The negative predictive value was 100% (35/35). The overall accuracy was 97.6% (40/41). FDG-PET had a therapeutic impact in 5 of 41 patients (12.2%). There was no impact of FDG-PET on management in other 36 patients. Conclusion FDG-PET is useful as primary method for detecting nodal recurrence and distant metastases in HNSCC as well as second cancer in subclinical patients as it had a high effectiveness. But systematic FDG-PET performed at 6 months in patients without any clinical suspicion of local recurrence was scarcely useful.