青贮玉米新品种临青1号配套栽培技术

临青1号是由临沧市种子管理站和四川农业大学以自育系XL8242为母本、自育系XL1449为父本杂交选育的青贮玉米单交种。2021-2022年在云南省开展多点区域试验和生产试验,2年区域试验每667m2平均产量(干重)1520.5kg,生产试验平均产量(干重)1493.3kg,高抗灰斑病、大斑病、小斑病、纹枯病,抗茎腐病,中抗南方锈病、普通锈病。2023年通过云南省农作物品种审定委员会审定,审定编号:滇审玉米2023162号。阐述了临青1号的特征特性、产量表现及配套栽培技术措施,为青贮玉米的选育和推广种植提供参考。

在孩子剧团里成长

作者以亲身经历讲述了诞生于抗日炮火中的孩子剧团的故事。这个由一群战时难童组成的小小剧团,经受了严峻的考验,赢得了广大民众的欢迎,作者就在这个特殊的剧团里成长为不到年龄的小共产党员。

宽城一老支书九年如一日守护烈士墓

1943年5月13日,在宽城王厂沟村,发生一起激烈的伏击战,在那场惨烈的战斗中,我军共歼灭日军150余人,而我军也有27名战士壮烈牺牲。为了怀念他们,人们在昔日的战场上竖起了烈士纪念碑。9年来,王厂沟村69岁的老支书刘广文,坚持义务为烈士扫墓,为前来祭奠的人讲解那段历史。烈士墓守护人王厂沟位于宽城满族自治县西南部孟子岭乡,南临长城喜峰口,北临燕山,东临青龙——平泉——喜峰口公路,是连接关内外的咽喉要道。

Evaluation of fracture properties of epoxy asphalt mixtures by SCB test

The fracture properties of epoxy asphalt mixtures （EAM） are evaluated based on J-integral and ultimate strength. Totally 60 semi-circular bending （SCB）specimens cored from superpave gyratory compactor （SGC）with three groups of notch depths are tested at the temperature of - 10 and 20 ℃. The experimental results reveal good repeatability in EAM characterization. The tensile strength ratio of SCB to the indirect tensile test （IDT） is at a range of 1.4 to 1.7, and the ultimate strength of EAM is exponentially dependent on the notch depths. At the test temperatures, the critical J-integral value of EAM is much higher than that of hot mix asphalt（ HMA） with thermoplastic asphalt binder. The response mode of EAM changes from ductile mode to brittle mode and the fracture energy increases 30% when temperature decreases from 20 to - 10℃, while its critical J-integral value decreases only 15%. It is concluded that EAM has better fracture resistance than thermo-plastic HMA; more fracture energy is needed to initiate cracks in EAM at low temperature, and the cracks propagate more rapidly than at room temperature.

Clinicopathologic characteristics of gastric carcinoma in elderly patients: A comparison with young patients

AIM:To examine the clinicopathologic features of elderly patients with gastric carcinoma and to investigate the relationship between prognosis and age.METHODS: We reviewed the hospital records of 2 014patients with gastric carcinoma retrospectively to compare the clinicopathologic findings in elderly (age ＞70 years) and young (age ＜36 years) patients during the period from 1986 to 2000 in a tertiary referral center in Gwangju, Korea. Overall survival was the main outcome measure.RESULTS: Of the 2 014 patients, 194 (9.6%) were in the elderly group and 137 (6.8%) were in the young group.The elderly and young patients had similar distributions with respect to depth of invasion, nodal involvement, hepatic metastasis, peritoneal dissemination, tumor stage at the initial diagnosis, and type of surgery. Synchronous multiple carcinomas were found in 14/194 (7.2%) of the elderly group and 4/137 (2.9%) of the young group (P＜0.05). Using the Borrmann classification, type Ⅳ was more frequent in the young patients than in the elderly patients (P＜0.05).Significantly more elderly patients had a well or moderately differentiated histology, and more young patients had a poorly differentiated histology and signet ring cell carcinoma (P＜0.001). The 5-year survival rates of elderly and young patients did not differ statistically (52.8% vs 46.5%,P = 0.5290). Multivariate analysis showed that the histologic type, nodal involvement and operative curability were significant prognostic factors, and age itself was not an independent prognostic factor of survival for elderly gastric carcinoma patients.CONCLUSION: Elderly patients with gastric carcinoma do not have a worse prognosis than young patients. The important prognostic factor is whether the patients undergo a curative resection.

Impact of release characteristics of sinomenine hydrochloride dosage forms on its pharmacokinetics in beagle dogs

AIM： To investigate the effect of release behavior of sustained-release dosage forms of sinomenine hydrochloride （SM·HCl） on its pharmacokinetics in beagle dogs. METHODS： The in vitro release behavior of two SM·HCl dosage forms, including commercial 12-h sustained-release tablets and 24-h sustained-release pellets prepared in our laboratory, was examined. The two dosage forms were orally administrated to beagle dogs, and then the in vivo SM.HCI pharmacokinetics was investigated and compared. RESULTS： The optimal SM·HCl sustained-release formulation was achieved by mixing slow- and rapidrelease pellets （9：1, w/w）. The SM·HCl release profiles of the sustained-release pellets were scarcely influenced by the pH of the dissolution medium. Release from the 12-h sustained-release tablets was markedly quicker than that from the 24-h sustained-release pellets, the cumulative release up to 12-h was 99.9% vs68.7%. From a pharmacokinetic standpoint, the 24-h SM.HCI sustainedrelease pellets had longer tmax and lower Cmax compared to the 12-h sustained-release tablets, the tmax being 2.67±0.52 h vs 9.83±0.98 h and the Cmax being 1334.45±368.76 ng/mL vs 893.12±292.55 ng/mL, respectively. However, the AUC0-tn of two SM·HCl dosage forms was comparable and both preparations were statistically bioequivalent. Furthermore, the two preparations had good correlations between SM·HCl percentage absorption in vivoand the cumulative percentage release in vitro. CONCLUSION： The in vitro release properties of the dosage forms strongly affect their pharmacokinetic behavior in vivo. Therefore, managing the in vitro release behavior of dosage forms is a promising strategy for obtaining the optimal in vivo pharmacokinetic characteristics and safe therapeutic drug concentration-time curves.

ACUPUNCTURE AND GLAUCOMA

It is to recognize glaucoma in view of Chinese medicine and synthesize the treatments and mechanisms of acupuncture on glaucoma in the paper. It is indicated in the results that acupuncture plays the importance in lowering ocular tension, improving ocular circulation and protecting optic nerve. Additionally, acupuncture inhibits probably the cellular apoptosis of optic ganglion and provides definite actions on psychological factors of glaucoma. Acupuncture cannot replace operation and medicinal therapy in lowing ocular tension, but their coordinated and auxiliary effects are quite clear and definite.

OBSERVATION ON THE THERAPEUTIC EFFECT OF ACUPUNCTURE TREATMENT OF 123 CASES OF SCAPULOHUMERAL PERIARTHRITIS

Objective: To observe the therapeutic effect of Qinglong Bai Wei Zhen Fa (Green Dragon Shaking Tail Needling) in the treatment of scapulohumeral periarthritis. Methods: A total of 231 cases of scapulohumeral periarthritis patients were randomized into treatment group (n=123) and control group (n=108). In treatment and control groups, Jianyu (LI 15), Jianqian and Jianhou were used as the main acupoints and stimulated with Green Dragon Shaking Tail Needling and conventional needling separately. Additionally, in control group, Waiguan (TE 5) and Binao (LI 14) were supplemented. The treatment was given once daily, with 10 days being a therapeutic course, 2 courses altogether. Results: After the first course of treatment, in treatment and control groups, the cured, the markedly improved, the effective and ineffective cases were 49 and 12, 61 and 33, 11 and 40, 2 and 23, with the total effective rates being 98.4% and 78.7% respectively. There was a marked difference between two groups in the therapeutic effect (P<0.05). Following 2 courses of treatment, the cured, the markedly improved, the effective and ineffective cases were 66 and 21, 47 and 41, 10 and 39, 0 and 7, with the total effective rates being 100% and 93.5% separately. No significant difference between two groups in the total effective rates, but the cure rate of treatment group was strikingly higher than that of control group. Conclusion: Green Dragon Shaking Tail Needling is significantly superior to that of conventional needling in the treatment of scapulohumeral periarthritis.

Peripheral primitive neuroectodermal tumor of the posterior mediastinum: A case report

Peripheral primitive neuroectodermal tumor(pPNET) is an extremely rare disease entity of malignant tumors belonging to the Ewing sarcoma family that usually occurs in children and adolescents. We describe a 41-year-old female who presented with right upper abdominal pain. Surgical resection and biopsy revealed small round-cell tumor. Combined with immunohistochemical analysis, pPNET was diagnosed. No evidence of recurrence was noted at 18 months postoperatively. Even thought pPNET is a highly malignant tumor, Wide tumor-free resection and multi-agent chemotherapy can also obtain good clinical outcomes.

Metastatic breast cancer to anterior chamber of eye:case report and discussion

Intraocular metastases are the most common malignancies of the eye. Carcinoma of the breast is the most common malignancy to metastasize to the uvea usually posterior uvea. Anterior chamber metastasis is extremely rare. We describe a patient of breast cancer who presented with pain and impaired vision in tight eye 8.5 months after metastasis to bone and other viscera were detected and more than 10 years after her primary disease was diagnosed. Multiple yellowish white deposits were noted scattered in anterior chamber giving rise to symptoms of acute narrow angle glaucoma. Metastatic deposits of duct cell carcinoma cells were found by fine needle aspiration cytology. Patient received local external beam radiotherapy to right eye with moderate improvement in her symptoms. The rare features in this case were clinical presentation of acute glaucoma and anterior chamber as the site of metastasis.

Cystinosis as a lysosomal storage disease with multiple mutant alleles: Phenotypic-genotypic correlations

Cystinosis is an autosomal recessive lysosomal storage dis-ease with an unclear enzymatic defect causing lysosomal cystine accumulation with no corresponding elevation of plasma cystine levels leading to multisystemic dysfunc-tion. The systemic manifestations include a proximal re-nal tubular defect （Fanconi-like）, endocrinal disturbances, eye involvements, with corneal, conjunctival and retinal depositions, and neurological manifestations in the form of brain and muscle dysfunction. Most of the long-term ill effects of cystinosis are observed particularly in pa-tients with long survival as a result of a renal transplant. Its responsible CTNS gene that encodes the lysosomal cystine carrier protein （cystinosin） has been mapped on the short arm of chromosome 17 （Ch17 p13）. There are three clinical forms based on the onset of main symp-toms： nephropathic infantile form, nephropathic juvenile form and non-nephropathic adult form with predominant ocular manifestations. Avoidance of eye damage from sun exposure, use of cystine chelators （cysteamine） and fnally renal transplantation are the main treatment lines. Pre-implantation genetic diagnosis for carrier parents is pivotal in the prevention of recurrence.

Production of De-asphalted Oil and Fine Asphalt Particles by Supercritical Extraction

A continuous three-stage supercritical fluid extraction (SFE) process with a capacity of 1.0kg.h^-1 was setup to extract petroleum residue by pentane to obtain more oil for further upgrading. A discharging system integrated to the bottom of the extractor was used to recover solvent as gas while asphalt was obtained as fine particles. The influence of operating conditions on the yield and quality of extracts, i.e., deasphalted oil (DAO) and resin, was studied in the range of temperature 150-220℃, pressure of 4.0-6.0 MPa and the mass ratio of solvent to oil feed (S/O) 2.5-5.0. The particle size distribution, apparent forms and the packing density, which vary with operating pressure, were measured. The particle structures were observed by SEM as well. With the modification to conventional processes, furnace can be eliminated for solvent recovery from asphalt phase, so as to reduce energy consumption.

Application of sinomenine in rheumatic diseases

Sinomenine is widely used in a variety of rheumatic diseases, and more and more attention has been paid to theadverse reaction in allergic reactions, digestive tract, blood, circulatory and nervous system. The application ofsinomenine in rheumatoid diseases and its side effects were reviewed here, which may provide a reference for thesafe and effective application of sinomenine preparations.

Beneficial clinical effects of grape seed proanthocyanidin extract on the progression of carotid atherosclerotic plaques

Background Atherosclerotic plaques indicate the occurrence of ischemia events and it is a difficult task for clinical physicians. Grape seed proanthocyanidin extract （GSPE） has been reported to exert an antiatherogenic effect by inducing regression of atherosclerotic plaques in animal experimental studies. In this study, the antiatherogenic effect of GSPE has been investigated in clinical use. Methods Consecu- tive 287 patients diagnosed with asymptomatic carotid plaques or abnormal plaque free carotid intima-media thickness （CIMT） were ran- domly assigned to the GSPE group （n = 146） or control group （n = 141）. The patients in the GSPE group received GSPE 200 mg per day orally, while patients in the control group were only enrolled in a lifestyle intervention program. Carotid ultrasound examination was per- formed at baseline and 6, 12, 24 months during follow-up. Mean maximum CIMT （MMCIMT）, plaque score, echogenicity of plaques and ischemic vascular events were recorded. Results As anticipated, after treatment, GSPE resulted in significant reduction in MMCIMT pro- gression （4.2% decrease after six months, 4.9% decrease after 12 months and 5.8% decrease after 24 months） and plaque score （10.9% de- crease after six months, 24.1% decrease after 12 months and 33.1% decrease after 24 months） for the primary outcome, while MMCIMT and plaque score were stable and even increased with the time going on in control group. The number of plaques and unstable plaques also de- creased after treatment of GSPE. Furthermore, the carotid plaque can disappear after treatment with GSPE. The incidence rate for transitory ischemic attack （TIA）, arterial revascularization procedure, and hospital readmission for unstable angina in GSPE group were statistically significant lower （P = 0.02, 0.08, 0.002, respectively） compared with the control group. Conclusions GSPE inhibited the progression of MMCIMT and reduced carotid plaque size in GSPE treated patients, and with extended treatment, the superior efficacy on MMCIMT and carotid plaque occurred. Furthermore, the GSPE group showed lower rates of clinical vascular events.

Empirical antibiotic treatment with piperacillin-tazobactam in Patients with microbiologically-documented biliary tract infections

AIM: To report our experience with empiric antimicrobial monotherapy (piperacillin/tazobactam, of which no data are available in such specific circumstances) in microbiologically-documented infections in patients with benign and malignant conditions of the biliary tract.METHODS: Twenty-three patients, 10 with benign and 13 with malignant conditions affecting the biliary tree and microbiologically-documented infections were recruited and the efficacy of empirical antibiotic therapy was assessed.RESULTS: The two groups featured similar demographic and clinical data. Overall, the infective episodes were most due to Gram negative agents, more than 60% of such episodes (mostly in malignant conditions) were preceded by invasive instrumental maneuvers. Empirical antibiotic therapy with a single agent (piperacillin/tazobactam) was effective in more than 80% of cases. No deaths were reported following infections. CONCLUSION: An empiric therapeutic approach with piperacillin/tazobactam is highly effective in biliary tract infections due to benign or malignant conditions.

Long term performance of warm mix asphalt versus hot mix asphalt

The fatigue behavior, indirect tensile strength （ITS） and resilient modulus test results for warm mix asphalt （WMA） as well as hot mix asphalt （HMA） at different ageing levels were evaluated. Laboratory-prepared samples were aged artificially in the oven to simulate short-term and long term ageing in accordance with AASHTO R30 and then compared with unaged specimens. Beam fatigue testing was performed using beam specimens at 25 ℃ based on AASHTO T321 standard. Fatigue life, bending stiffness and dissipated energy for both unaged and aged mixtures were calculated using four-point beam fatigue test results. Three-point bending tests were performed using semi-circular bend （SCB） specimens at -10 ℃ and the critical mode I stress intensity factor K1 was then calculated using the peak load obtained from the load-displacement curve. It is observed that Sasobit and Rheofalt warm mix asphalt additives have a significant effect on indirect tensile strength, resilient modulus, fatigue behavior and stress intensity factor of aged and unaged mixtures.

Clinical blood routine and bone marrow smear manifestations of disseminated penicilliosis marneffei

OBJECTIVE: To investigate the manifestation of clinical, blood routine and bone marrow smear of disseminated penicilliosis marneffei. METHODS: There were 13 cases of penicilliosis marneffei whose peripheral blood had been drawn for routine tests, as well as blood and bone marrow aspiration for smears. Wright's-Giemsa stain, Gomori's methenamine-silver stain (GMS) and periodic acid Schiff's reaction (PAS) were performed for light microscopy in consultation with pathologic diagnosis and fungi culture for precise diagnosis. RESULTS: Seven cases of bone marrow and 2 peripheral blood smears were found positive for penicillium marneffei in the test group. The morphology of penicillium marneffei was extremely similar to that of histoplasma capsulatum. However, the observation of sausage cells and central cross wall, which are signs of dividing by fission and not by budding, aided in differential diagnosis. CONCLUSION: Bone marrow smear or occasional blood smear examination play an important role in the diagnosis of disseminated penicilliosis marneffei.

东湖落雁景区旖旎风光

东湖落雁景区是国家5A级东湖风景名胜区的重要组成部分,它北依白马景区,南与磨山景区隔湖相望,东临青王公路,规划用地总面积为10.24平方公里,其中陆地5.92平方公里,水域4.32平方公里。自2000年起,东湖风景区管理局利用三期旅游国债资金开发建设落雁景区自然生态园,先后建成了清河古桥、鹊桥相会、雁洲索桥、芦洲古渡、赵氏花园、古树奇观、雁栖坪沙、芦洲落雁等八大景观。

紧抓民生谋发展 开创桃源新篇章

桃源社区地处景色秀丽的惠山脚下,东临青山西路,西倚鸿桥路,南接梁溪路,北靠嶂山、青山,社区占地面积3.1平方公里。毗邻万达核心商业圈,地理位置十分优越。桃源社区于2005年9月由桃园社区、上里东社区、河埒村整合而成。共有居民4903户,常住人口13952人。社区党委下设十二个党支部,共有党员555名。社区建有面积达3000平米的"一厅十室二中心",一厅为社区事务受理大厅,设有民政、老龄、残疾人管理、社会保障、

顺溪古建筑群 一座民居博物馆

金秋十月,闻着桂花的香味,踏进了顺溪镇。很早的时候就听说了"青街竹,顺溪屋"这句流行于平阳民间的古老谚语,上了年纪的老人都说古民居是平阳文化遗产的一大特色,而顺溪古建筑群就是其中的典型代表。顺溪地处平阳县西部的螯江上游,东临青街畲族乡,北与文成县接壤,是一个历史悠久的名镇。