In this paper we study the stability analysis of two within-host Chikungunya virus (CHIKV) dynamics models. The incidence rate between the CHIKV and the uninfected mouocytes is modeled by a general nonlinear functio...In this paper we study the stability analysis of two within-host Chikungunya virus (CHIKV) dynamics models. The incidence rate between the CHIKV and the uninfected mouocytes is modeled by a general nonlinear function. The second model considers two types of infected monocytes (i) latently infected monocytes which do not generate CHIKV and (ii) actively infected monocytes which produce the CHIKV particles. Sufficient conditions are found which guarantee the global stability of the positive steady states. Using the Lyapunov function, we established the global stability of the steady states of the models. The theoretical results are confirmed by numerical simulations.展开更多
文摘In this paper we study the stability analysis of two within-host Chikungunya virus (CHIKV) dynamics models. The incidence rate between the CHIKV and the uninfected mouocytes is modeled by a general nonlinear function. The second model considers two types of infected monocytes (i) latently infected monocytes which do not generate CHIKV and (ii) actively infected monocytes which produce the CHIKV particles. Sufficient conditions are found which guarantee the global stability of the positive steady states. Using the Lyapunov function, we established the global stability of the steady states of the models. The theoretical results are confirmed by numerical simulations.