Taking the city of Qitaihe is as an example in order to provide practical methods for the selection of leading industries for coal resource cities, this paper establishes the specific operation scheme for selection of...Taking the city of Qitaihe is as an example in order to provide practical methods for the selection of leading industries for coal resource cities, this paper establishes the specific operation scheme for selection of leading industries according to the actual situation of coal resource cities based on the theory of coupling coordination together with the coupling coordination for technological innovation. The results show that the degree for coupling coordination of the technological innovation for each alternative industry differentiates with the development of coal resource cities. For example, the average degree of food processing industry from agricultural produce is 0.9. Therefore, coal resource cities should develop some industries related to coal industry, such as coking industry, some chemical and medicines industry and non-metallic mineral products manufacturing, in the near future, however, some industries with greater market and influence potentials and low carbon emissions should be attached much importance to in the future.展开更多
Objective：We investigated whether disturbance of calcium and phosphate metabolism is associated with the presence and severity of calcific aortic valve disease （CAVD） in patients with normal or mildly impaired rena...Objective：We investigated whether disturbance of calcium and phosphate metabolism is associated with the presence and severity of calcific aortic valve disease （CAVD） in patients with normal or mildly impaired renal function. Methods：We measured serum levels of calcium, phosphate, alkaline phosphatase （AKP）, intact parathyroid hormone （iPTH）, 25-hydroxyvitamin D （25-OHD）, and biomarkers of bone turnover in 260 consecutive patients with normal or mildly impaired renal function and aortic valve sclerosis （AVSc） （n=164） or stenosis （AVS） （n=96） and in 164 age- and gender-matched controls. Logistic regression models were used to determine the association of mineral metabolism parameters with the presence and severity of CAVD. Results：Stepwise increases were observed in serum levels of calcium, phosphate, AKP, and iPTH from the control group to patients with AVS, and with reverse changes for 25-OHD levels （al P〈0.001）. Similarly, osteocalcin, procol agen I N-terminal peptide, andβ-isomerized type I col agen C-telopeptide breakdown products were significantly increased stepwise from the control group to patients with AVS （al P〈0.001）. In patients with AVS, serum levels of iPTH were positively, in contrast 25-OHD levels were negatively, related to trans-aortic peak flow velocity and mean pressure gradient. After adjusting for relevant confounding varia-bles, increased serum levels of calcium, phosphate, AKP, and iPTH and reduced serum levels of 25-OHD were in-dependently associated with the presence and severity of CAVD. Conclusions： This study suggests an association between mineral metabolism disturbance and the presence and severity of CAVD in patients with normal or mildly impaired renal function. Abnormal bone turnover may be a potential mechanism.展开更多
基金provided by the National Natural Science Foundation of China (No. 70972098)
文摘Taking the city of Qitaihe is as an example in order to provide practical methods for the selection of leading industries for coal resource cities, this paper establishes the specific operation scheme for selection of leading industries according to the actual situation of coal resource cities based on the theory of coupling coordination together with the coupling coordination for technological innovation. The results show that the degree for coupling coordination of the technological innovation for each alternative industry differentiates with the development of coal resource cities. For example, the average degree of food processing industry from agricultural produce is 0.9. Therefore, coal resource cities should develop some industries related to coal industry, such as coking industry, some chemical and medicines industry and non-metallic mineral products manufacturing, in the near future, however, some industries with greater market and influence potentials and low carbon emissions should be attached much importance to in the future.
基金Project supported by the Science and Technology Commission of Shanghai Municipality(No.114119a8800),China
文摘Objective：We investigated whether disturbance of calcium and phosphate metabolism is associated with the presence and severity of calcific aortic valve disease （CAVD） in patients with normal or mildly impaired renal function. Methods：We measured serum levels of calcium, phosphate, alkaline phosphatase （AKP）, intact parathyroid hormone （iPTH）, 25-hydroxyvitamin D （25-OHD）, and biomarkers of bone turnover in 260 consecutive patients with normal or mildly impaired renal function and aortic valve sclerosis （AVSc） （n=164） or stenosis （AVS） （n=96） and in 164 age- and gender-matched controls. Logistic regression models were used to determine the association of mineral metabolism parameters with the presence and severity of CAVD. Results：Stepwise increases were observed in serum levels of calcium, phosphate, AKP, and iPTH from the control group to patients with AVS, and with reverse changes for 25-OHD levels （al P〈0.001）. Similarly, osteocalcin, procol agen I N-terminal peptide, andβ-isomerized type I col agen C-telopeptide breakdown products were significantly increased stepwise from the control group to patients with AVS （al P〈0.001）. In patients with AVS, serum levels of iPTH were positively, in contrast 25-OHD levels were negatively, related to trans-aortic peak flow velocity and mean pressure gradient. After adjusting for relevant confounding varia-bles, increased serum levels of calcium, phosphate, AKP, and iPTH and reduced serum levels of 25-OHD were in-dependently associated with the presence and severity of CAVD. Conclusions： This study suggests an association between mineral metabolism disturbance and the presence and severity of CAVD in patients with normal or mildly impaired renal function. Abnormal bone turnover may be a potential mechanism.
