Objective:To determine the efficacy and safety of oral erythromycin(EM) for feeding intolerance in preterm infants < 35 weeks gestation. Study design:In this randomized,double blinded,placebo-controlled trial,prete...Objective:To determine the efficacy and safety of oral erythromycin(EM) for feeding intolerance in preterm infants < 35 weeks gestation. Study design:In this randomized,double blinded,placebo-controlled trial,preterm infants with feeding intolerance were randomly allocated to a treatment group given EM ethyl succinate 10 mg/kg every 6 hours for 2 days,followed by 4 mg/kg every 6 hours for another 5 days,or to a control group given placebo. The primary outcome was time to full feeding (150 mL/kg/day) after the start of treatment.Results:Each group comprised 23 preterm infants,almost all of whom were < 32 weeks gestation. Baseline characteristics were similar between the 2 groups. Times to full feeding were significantly shorter and the number of with held feeds were significantly less in the EM group than the control group; the respective medians (interquartile ranges) were 7 days (6 to 9 days) versus 13 days (9 to 15 days) (P < 0.001) and 1 episode (0 to 2 episodes) versus 9 episodes (2 to 13 episodes) (P < 0.001).No significant differences in episodes of sepsis,necrotizing enterocolitis,and cholestasis were observed. Conclusions:Oral EM was effective and safe for treatment of feeding intolerance in preterm infants.展开更多
文摘Objective:To determine the efficacy and safety of oral erythromycin(EM) for feeding intolerance in preterm infants < 35 weeks gestation. Study design:In this randomized,double blinded,placebo-controlled trial,preterm infants with feeding intolerance were randomly allocated to a treatment group given EM ethyl succinate 10 mg/kg every 6 hours for 2 days,followed by 4 mg/kg every 6 hours for another 5 days,or to a control group given placebo. The primary outcome was time to full feeding (150 mL/kg/day) after the start of treatment.Results:Each group comprised 23 preterm infants,almost all of whom were < 32 weeks gestation. Baseline characteristics were similar between the 2 groups. Times to full feeding were significantly shorter and the number of with held feeds were significantly less in the EM group than the control group; the respective medians (interquartile ranges) were 7 days (6 to 9 days) versus 13 days (9 to 15 days) (P < 0.001) and 1 episode (0 to 2 episodes) versus 9 episodes (2 to 13 episodes) (P < 0.001).No significant differences in episodes of sepsis,necrotizing enterocolitis,and cholestasis were observed. Conclusions:Oral EM was effective and safe for treatment of feeding intolerance in preterm infants.
