To promote the efficiency of knowledge base retrieval based on description logic, the concept of assertional graph (AG), which is directed labeled graph, is defined and a new AG-based retrieval method is put forward...To promote the efficiency of knowledge base retrieval based on description logic, the concept of assertional graph (AG), which is directed labeled graph, is defined and a new AG-based retrieval method is put forward. This method converts the knowledge base and query clause into knowledge AG and query AG by making use of the given rules and then makes use of graph traversal to carry out knowledge base retrieval. The experiment indicates that the efficiency of this method exceeds, respectively, the popular RACER and KAON2 system by 0.4% and 3.3%. This method can obviously promote the efficiency of knowledge base retrieval.展开更多
Objective: To study the clinical significance of multi-slice spiral CT 3-dimensional (3D) portography in portal vein tumor thrombosis of hepatocellular cacinoma.Methods: 57 cases undergoing 3D portography were collect...Objective: To study the clinical significance of multi-slice spiral CT 3-dimensional (3D) portography in portal vein tumor thrombosis of hepatocellular cacinoma.Methods: 57 cases undergoing 3D portography were collected, of which 6 cases were normal, 5 cases were subjected to cirrhosis and hypertension of portal vein, 42 cases had portal tumor thrombus of hepatic cancer, and the remaining 4 cases showed lymph node enlargment in hilar of liver. All data of the patients came from conventional multi-slice spiral CT double phase of liver. Contrast media was 1.5–2 ml/kg with the injection rate being 2.5–3 ml/s. Axis and 3D portography was analyzed and compared in 42 cases of portal tumor thrombus of hepatic cancer.Results: According to portal tumor thrombus position, 42 cases were fallen into three categories: left (13 cases), right (20 cases), main (9 cases) of potal vein. There was no difference between axis and 3D portography in displaying portal tumor thrombus of hepatic cancer (P>0.05), but 3D portography showing collateral branches was better than axis portography after main portal vein thrombus.Conclusion: Multi-slice spiral CT 3D portography can display the position and types of portal tumor thrombus of hepatic cancer. 3D combined with axis portography can better evaluate the portal tumor thrombus of hepatic cancer and guide to select the therapies. Key words portal vein - tumor thrombus - multi-slice CT - 3 dimension imaging展开更多
The one-block version of ordered subsets (OS) techniques was used to accelerate the convergent rate of the space-alternating generalized expectation-maximization (SAGE) algorithm. The new row-action SAGE (RA-SAGE) alg...The one-block version of ordered subsets (OS) techniques was used to accelerate the convergent rate of the space-alternating generalized expectation-maximization (SAGE) algorithm. The new row-action SAGE (RA-SAGE) algorithm processed projections in sequentially orthogonal order which reduced the dependency among the projections and speeds up the convergences. Additionally, the over-relaxation parameter in the direction defined by the RA-SAGE algorithm was also applied to obtain fast convergence to a globally maximum likelihood (ML) solution. In experiments, the RA-SAGE algorithm and the classical SAGE algorithm were compared in the application to positron emission tomography (PET) image reconstruction. Simulation results showed that RA-SAGE had better performance than SAGE in both convergence and image quality.展开更多
A user-defined micromechanical model was developed to investigate the fracture mechanism of asphalt concrete (AC) using the discrete element method (DEM). A three-dimensional (3D) AC beam was built using the "F...A user-defined micromechanical model was developed to investigate the fracture mechanism of asphalt concrete (AC) using the discrete element method (DEM). A three-dimensional (3D) AC beam was built using the "Fish" language provided by PFC3D and was employed to simulate the three-point bending beam test at two temperature levels: -10 ℃ and 15℃. The AC beam was modeled with the consideration of the microstructural features of asphalt mixtures. Uniaxial complex modulus test and indirect tensile strength test were conducted to obtain material input parameters for numerical modeling. The 3D predictions were validated using laboratory experimental measurements of AC beams prepared by the same mixture design. Effects of mastic stiffness, cohesive and adhesive strength on AC fracture behavior were investigated using the DEM model. The results show that the 3D DEM fracture model can accurately predict the fracture patterns of asphalt concrete. The ratio of stress at interfaces to the stress in mastics increases as the mastic stiffness decreases; however, the increase in the cohesive strength or adhesive strength shows no significant influence on the tensile strength.展开更多
AIM:To review safety,efficacy,and proper nursing care of double-balloon enteroscopy (DBE) in pediatric patients with small intestinal disease.METHODS:Our study included 37 patients with abdominal pain,diarrhea,passage...AIM:To review safety,efficacy,and proper nursing care of double-balloon enteroscopy (DBE) in pediatric patients with small intestinal disease.METHODS:Our study included 37 patients with abdominal pain,diarrhea,passage of blood in the stools,and other symptoms,who underwent DBE from December 2006 to July 2010.DBE was retrograde in 36 procedures,antegrade in six,and from both ends in five.The diagnostic significance and salient points in nursing care are discussed in this article.RESULTS:At least one lesion was discovered in 28 out of 37 patients,which yielded a positive diagnosis in 75.7% of cases.Good bowel preparation and skilled nursing care not only shortened the procedure time,but could also alleviate patient discomfort and enhance the quality of examination.No serious procedure-related complications were observed in any cases.CONCLUSION:DBE is a new modality of endoscopic procedure that improves the standard of diagnosis and treatment of small bowel diseases in children.Good nursing care is essential to the successful execution of the procedure.展开更多
By using the observed monthly mean data over 160 stations of China and NCAR/NCEP reanalysis data, the generalized equilibrium feedback assessment(GEFA) method, combined with the methods of EOF analysis, correlation an...By using the observed monthly mean data over 160 stations of China and NCAR/NCEP reanalysis data, the generalized equilibrium feedback assessment(GEFA) method, combined with the methods of EOF analysis, correlation and composite analysis, is used to explore the influence of different SST modes on a wintertime air temperature pattern in which it is cold in the northeast and warm in the southwest in China. The results show that the 2009/2010 winter air temperature oscillation mode between the northern and southern part of China is closely related to the corresponding sea surface temperature anomalies(SSTA) and its associated atmospheric circulation anomalies. Exhibiting warming in Northeast China and cooling in Southwest China, the mode is significantly forced by the El Nio mode and the North Atlantic SSTA mode, which have three poles. Under the influence of SSTA modes, the surface northerly flow transported cold air to North and Northeast China, resulting in low temperatures in the regions. Meanwhile, the mid-latitude westerlies intensify and the polar cold air stays in high latitudes and cannot affect the Southwest China, resulting in the warming there.展开更多
There is an ongoing discussion on how to diagnose a hyperechogenic pancreas and what is the clinical significance of diffusely hyperechogenic pancreas. Computerized tomography and magnetic resonance imaging are the mo...There is an ongoing discussion on how to diagnose a hyperechogenic pancreas and what is the clinical significance of diffusely hyperechogenic pancreas. Computerized tomography and magnetic resonance imaging are the more appropriate methods to diagnose pancreatic hyperechogenicity when compared with transcutaneous or endoscopic ultrasound examination. More importantly, pancreatic hyperechogenicity may not be a certain indicator of pancreatic fat infiltration. Even if it is true, we do not know the clinical significances of pancreatic fat accumulation. Some suggested that excess fat in the pancreas is associated with chronic pancreatitis. However, several histological studies on human alcoholic chronic pancreatitis did not prove the presence of fatty pancreas in such cases. Thus, except for aging, it is very rare to have truly steatotic pancreas in the absence of certain human diseases.展开更多
Objective: To evaluate the accuracy of these two methods and focus on the analysis and management of the false-negative cases. Methods: Results of full field digital mammography (FFDM) and fine needle aspiration cytol...Objective: To evaluate the accuracy of these two methods and focus on the analysis and management of the false-negative cases. Methods: Results of full field digital mammography (FFDM) and fine needle aspiration cytology (FNAC) were obtained and analyzed from a consecutive of 102 women with palpable breast masses, results were correlated with the histopathological findings. Results: Of the 102 cases, malignancy was confirmed in 43 cases (42.16%) by final pathological examination, the sensitivity and specificity of cancer detection with FNA cytology was 90.7% (39/43) and 89.8% (53/59), re- spectively, the whole accuracy was 90.2% (92/102), with a positive predictive value of 86.7% (39/45) and a negative predictive value of 93.0% (53/57). FFDM gave a sensitivity of 88.4% (38/43), specificity of 83.1% (49/59), and whole accuracy 85.3% (87/102), the positive predictive value and negative predictive value was 79.2% (38/48) and 90.7% (49/54), respectively. All the FNAC-negative cancer cases were suggestive of malignancy by FFDM findings, however, the benign cases which present as equivocal finding by FNA cytology, could not be ruled out the presence of malignancy. Conclusion: FNAC and FFDM both are accurate, effective and economical diagnostic modalities, combined use of these two methods can reduced the misdiag- nosis rate of breast masses.展开更多
Ethnic assertions worldwide have assumed different forms ranging from moderate methods of articulation of autonomy to extremist means of violent struggle. Resort to extremism by some sections of an ethnic group usuall...Ethnic assertions worldwide have assumed different forms ranging from moderate methods of articulation of autonomy to extremist means of violent struggle. Resort to extremism by some sections of an ethnic group usually triggers inter-ethnic conflicts with other groups on the one hand and leads to confrontation with the state on the other. This paper seeks to examine the dynamics of this phenomenon in the context of Bodos, the largest plains tribe of Assam, a State of Northeast India. The paper enquires as to whether extremist politics has met the Bodo aspirations for self-determination or has intensified the conflicts and contradictions within the Bodo society with ramifications for other ethnic groups inhabiting the Bodo-dominated areas. It is also necessary to explore the responses of the Union and State governments to Bodo extremist politics for an understanding of the conflict management process.展开更多
AIM: To study the patients with main pancreatic duct dilation on computed tomography (CT) and thereby to provide the predictive criteria to identify patients at high risk of significant diseases, such as pancreatic ca...AIM: To study the patients with main pancreatic duct dilation on computed tomography (CT) and thereby to provide the predictive criteria to identify patients at high risk of significant diseases, such as pancreatic cancer, and to avoid unnecessary work up for patients at low risk of such diseases. METHODS: Patients with dilation of the main pancreatic duct on CT at Emory University Hospital in 2002 were identified by computer search. Clinical course and ultimate diagnosis were obtained in all the identified patients by abstraction of their computer database records. RESULTS: Seventy-seven patients were identified in this study. Chronic pancreatitis and pancreatic cancer were the most common causes of the main pancreatic duct dilation on CT. Although the majority of patients with isolated dilation of the main pancreatic duct (single duct dilation) had chronic pancreatitis, one-third of patients with single duct dilation but without chronic pancreatitis had pancreatic malignancies, whereas most of patients with concomitant biliary duct dilation (double duct dilation) had pancreatic cancer. CONCLUSION: Patients with pancreatic double duct dilation need extensive work up and careful followup since a majority of these patients are ultimately diagnosed with pancreatic cancer. Patients with single duct dilation, especially such patients without any evidence of chronic pancreatitis, also need careful follow-up since the possibility of pancreatic malignancy, including adenocarcinoma and intraductal papillary mucinous tumors, is still high.展开更多
The comparative studies on micromorphological features in diagnostic horizons of Stagnic Anthrosols, Ustic Ferrosols and Ustic Vertosols in southwestern China were conducted to underpin the rationale for Chinese Soil ...The comparative studies on micromorphological features in diagnostic horizons of Stagnic Anthrosols, Ustic Ferrosols and Ustic Vertosols in southwestern China were conducted to underpin the rationale for Chinese Soil Taxonomy. The following findings were explored: (1) Stagnic Anthrosols had the specific micromorphological features, e.g., the humic formation in anthrostagnic epipedon, the platy structures in plow subhorizon, the secondary formation of ferromanganese and the weakly optical-orientation clay domains in hydragric horizon, etc.: (2) The groundmasses of ferric horizon in Ustic Ferrosols appeared in hue of 2.5YR or redder, and had pellicular grain structure; (3) Ustic Vertosols had a crust horizon (Acr), and crack structure dominated in Acr and angular blocky structure in disturbed horizon; (4) Because of the distinct differences in micromorphological features among these three soils, the specific micromorphological features might be employed as diagnostic horizons to differentiate soils while the quantifiable micromorphological features might potentially be selected as diagnostic indices for Chinese soil taxonomic classification.展开更多
AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This stu...AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP.展开更多
D.H.Lawrence is a great writer and Woman in Love is considered as his masterpiece and one of the undoubted classic ofthe 20tb century. Through his flexible application of symbolism, the novel is presented with fragmen...D.H.Lawrence is a great writer and Woman in Love is considered as his masterpiece and one of the undoubted classic ofthe 20tb century. Through his flexible application of symbolism, the novel is presented with fragmentary scenes instead of the usual plots, and a lot of separate and unrelated images are employed to reflect the mental conflicts among the major characters. By analyzing the symbolism in this paper, the author hopes to find the importance of symbolism in strengthening the distinct characteristics, enhancing the development of the plot, and hence the emphasis of the theme of the novel.展开更多
This article is one of the serial studies oll the characteristics of the molecular structure for dystrophin gene in Chinese. By using the entire dystrophin cDNA (14 kb) as a probe- the number and RFLPs of Bgl Ⅱ exon-...This article is one of the serial studies oll the characteristics of the molecular structure for dystrophin gene in Chinese. By using the entire dystrophin cDNA (14 kb) as a probe- the number and RFLPs of Bgl Ⅱ exon-containing fragments of the dystrophin gene were analysed. Four new Bgl Ⅱ fragments were found, two of them (3.7 and 6.2 kb) detected by comparing the hybridization patterns with cDNA1-2a. 1a and 2a, one (9.3 kb) from the hybridization pattern with cDNA 9 by lengthening migrating distance of DNA fragments in electrophoresis. and another one (4.0 kb) by comparing the patterns with cDNA 11-14,11a- 11b’ 11c-12a and 14. The results indicated that the number of Bgl Ⅱ exon-containing fragments should be 59 rather than 55 reported previously, which laid the foundation of the Bgl Ⅱ partial restriction map for dystrophin gene. Three of the four RFLPs found in Caucacian appear in the hybridization patterns of three subclones, i.e.cDNA 2b-3. cDNA 4-5, and cDNA 5b-7.’ The values of expected heterozygote frequency (EHF) were 0.33, 0.33and 0.40 and the observed heterozygote frequency (OHF)were 0.40. 0.40 and 0.48 respectively. Meanwhile, two new rare allelic fragments (15 kb) were found in RFLPs from Bgl Ⅱ/2b-3 and Bgl Ⅱ/4-5a patterns respectively. These Bgl Ⅱ RFLPs and four XbaI RFLPs documented in our laboratory, have been used to detect the carrier in 7 DMDfamilies and 1 BMD family. Of the 69 individuals from the 8 families- 11 females were diagnosed as the carriers with DMD mutation, 4 females as the doubtful carriers, 12 females were defined as normal genotype and 2 females as probably normal. The results suggest that the carrier testing method based on dosage intensity analysis and genotype analysis by using dystrophin cDNA as a probe will be more sensitive and accurate.展开更多
Located at the west of the Linfen basin, the Luoyunshan piedmont fault zone controls the western boundary of the basin. According to the measurements of the terraces in eight gullies along the Luoyunshan fault zone, f...Located at the west of the Linfen basin, the Luoyunshan piedmont fault zone controls the western boundary of the basin. According to the measurements of the terraces in eight gullies along the Luoyunshan fault zone, five levels of terraces, namely T1~T5 have developed in these gullies. The heights of terraces T1, T2, T3, T4 and T5 are about 3m, 8~10m, about 20m, about 30m and 40~50m, respectively. The dating data of the terraces and investigation of the faulted landforms show that the Luoyunshan fault zone has experienced much activity since the Late Quaternary. The uplift rate of the terraces was 0.41mm/a since the Middle-Late Pleistocene, and 0.75mm/a since the Holocene. The increasing trend of uplift rate of the terraces along the Luoyunshan fault zone from the Middle-Late Pleistocene to Holocene indicates the tendency of gradual tectonic uplift of the fault zone since the late Quaternary. This is in good agreement with the increasing trend of subsidence rate of the Linfen basin from the Late Pleistocene to Holocene.展开更多
Despite great efforts in experimental and clinical research, the prognosis of pancreatic cancer (PC) has not changed significantly for decades. Detection of pre-invasive lesions or early-stage PC with small resectable...Despite great efforts in experimental and clinical research, the prognosis of pancreatic cancer (PC) has not changed significantly for decades. Detection of pre-invasive lesions or early-stage PC with small resectable cancers in asymptomatic individuals remains one of the most promising approaches to substantially improve the overall outcome of PC. Therefore, screening programs have been proposed to identify curable lesions especially in individuals with a familial or genetic predisposition for PC. In this regard, Canto et al recently contributed an important article comparing computed tomography, magnetic resonance imaging, and endoscopic ultrasound for the screening of 216 asymptomatic high-risk individuals (HRI). Pancreatic lesions were detected in 92 of 216 asymptomatic HRI (42.6%). The high diagnostic yield in this study raises several questions that need to be answered of which two will be discussed in detail in this commentary: First: which imaging test should be performed? Second and most importantly: what are we doing with incidentally detected pancreatic lesions? Which ones can be observed and which ones need to be resected?展开更多
基金The National Natural Science Foundation of China(No.69975010,60374054),the National Research Foundation for the Doctoral Program of Higher Education of China (No.20050007023).
文摘To promote the efficiency of knowledge base retrieval based on description logic, the concept of assertional graph (AG), which is directed labeled graph, is defined and a new AG-based retrieval method is put forward. This method converts the knowledge base and query clause into knowledge AG and query AG by making use of the given rules and then makes use of graph traversal to carry out knowledge base retrieval. The experiment indicates that the efficiency of this method exceeds, respectively, the popular RACER and KAON2 system by 0.4% and 3.3%. This method can obviously promote the efficiency of knowledge base retrieval.
文摘Objective: To study the clinical significance of multi-slice spiral CT 3-dimensional (3D) portography in portal vein tumor thrombosis of hepatocellular cacinoma.Methods: 57 cases undergoing 3D portography were collected, of which 6 cases were normal, 5 cases were subjected to cirrhosis and hypertension of portal vein, 42 cases had portal tumor thrombus of hepatic cancer, and the remaining 4 cases showed lymph node enlargment in hilar of liver. All data of the patients came from conventional multi-slice spiral CT double phase of liver. Contrast media was 1.5–2 ml/kg with the injection rate being 2.5–3 ml/s. Axis and 3D portography was analyzed and compared in 42 cases of portal tumor thrombus of hepatic cancer.Results: According to portal tumor thrombus position, 42 cases were fallen into three categories: left (13 cases), right (20 cases), main (9 cases) of potal vein. There was no difference between axis and 3D portography in displaying portal tumor thrombus of hepatic cancer (P>0.05), but 3D portography showing collateral branches was better than axis portography after main portal vein thrombus.Conclusion: Multi-slice spiral CT 3D portography can display the position and types of portal tumor thrombus of hepatic cancer. 3D combined with axis portography can better evaluate the portal tumor thrombus of hepatic cancer and guide to select the therapies. Key words portal vein - tumor thrombus - multi-slice CT - 3 dimension imaging
文摘The one-block version of ordered subsets (OS) techniques was used to accelerate the convergent rate of the space-alternating generalized expectation-maximization (SAGE) algorithm. The new row-action SAGE (RA-SAGE) algorithm processed projections in sequentially orthogonal order which reduced the dependency among the projections and speeds up the convergences. Additionally, the over-relaxation parameter in the direction defined by the RA-SAGE algorithm was also applied to obtain fast convergence to a globally maximum likelihood (ML) solution. In experiments, the RA-SAGE algorithm and the classical SAGE algorithm were compared in the application to positron emission tomography (PET) image reconstruction. Simulation results showed that RA-SAGE had better performance than SAGE in both convergence and image quality.
基金Project(51208178)supported by the National Natural Science Foundation of ChinaProject(2012M520991)supported by China Postdoctoral Science Foundation
文摘A user-defined micromechanical model was developed to investigate the fracture mechanism of asphalt concrete (AC) using the discrete element method (DEM). A three-dimensional (3D) AC beam was built using the "Fish" language provided by PFC3D and was employed to simulate the three-point bending beam test at two temperature levels: -10 ℃ and 15℃. The AC beam was modeled with the consideration of the microstructural features of asphalt mixtures. Uniaxial complex modulus test and indirect tensile strength test were conducted to obtain material input parameters for numerical modeling. The 3D predictions were validated using laboratory experimental measurements of AC beams prepared by the same mixture design. Effects of mastic stiffness, cohesive and adhesive strength on AC fracture behavior were investigated using the DEM model. The results show that the 3D DEM fracture model can accurately predict the fracture patterns of asphalt concrete. The ratio of stress at interfaces to the stress in mastics increases as the mastic stiffness decreases; however, the increase in the cohesive strength or adhesive strength shows no significant influence on the tensile strength.
文摘AIM:To review safety,efficacy,and proper nursing care of double-balloon enteroscopy (DBE) in pediatric patients with small intestinal disease.METHODS:Our study included 37 patients with abdominal pain,diarrhea,passage of blood in the stools,and other symptoms,who underwent DBE from December 2006 to July 2010.DBE was retrograde in 36 procedures,antegrade in six,and from both ends in five.The diagnostic significance and salient points in nursing care are discussed in this article.RESULTS:At least one lesion was discovered in 28 out of 37 patients,which yielded a positive diagnosis in 75.7% of cases.Good bowel preparation and skilled nursing care not only shortened the procedure time,but could also alleviate patient discomfort and enhance the quality of examination.No serious procedure-related complications were observed in any cases.CONCLUSION:DBE is a new modality of endoscopic procedure that improves the standard of diagnosis and treatment of small bowel diseases in children.Good nursing care is essential to the successful execution of the procedure.
基金Specialized Science Project for Public Welfare Industries(Meteorology)(GYHY200906016)State Key Program of National Natural Science Foundation of China(41230528)
文摘By using the observed monthly mean data over 160 stations of China and NCAR/NCEP reanalysis data, the generalized equilibrium feedback assessment(GEFA) method, combined with the methods of EOF analysis, correlation and composite analysis, is used to explore the influence of different SST modes on a wintertime air temperature pattern in which it is cold in the northeast and warm in the southwest in China. The results show that the 2009/2010 winter air temperature oscillation mode between the northern and southern part of China is closely related to the corresponding sea surface temperature anomalies(SSTA) and its associated atmospheric circulation anomalies. Exhibiting warming in Northeast China and cooling in Southwest China, the mode is significantly forced by the El Nio mode and the North Atlantic SSTA mode, which have three poles. Under the influence of SSTA modes, the surface northerly flow transported cold air to North and Northeast China, resulting in low temperatures in the regions. Meanwhile, the mid-latitude westerlies intensify and the polar cold air stays in high latitudes and cannot affect the Southwest China, resulting in the warming there.
文摘There is an ongoing discussion on how to diagnose a hyperechogenic pancreas and what is the clinical significance of diffusely hyperechogenic pancreas. Computerized tomography and magnetic resonance imaging are the more appropriate methods to diagnose pancreatic hyperechogenicity when compared with transcutaneous or endoscopic ultrasound examination. More importantly, pancreatic hyperechogenicity may not be a certain indicator of pancreatic fat infiltration. Even if it is true, we do not know the clinical significances of pancreatic fat accumulation. Some suggested that excess fat in the pancreas is associated with chronic pancreatitis. However, several histological studies on human alcoholic chronic pancreatitis did not prove the presence of fatty pancreas in such cases. Thus, except for aging, it is very rare to have truly steatotic pancreas in the absence of certain human diseases.
文摘Objective: To evaluate the accuracy of these two methods and focus on the analysis and management of the false-negative cases. Methods: Results of full field digital mammography (FFDM) and fine needle aspiration cytology (FNAC) were obtained and analyzed from a consecutive of 102 women with palpable breast masses, results were correlated with the histopathological findings. Results: Of the 102 cases, malignancy was confirmed in 43 cases (42.16%) by final pathological examination, the sensitivity and specificity of cancer detection with FNA cytology was 90.7% (39/43) and 89.8% (53/59), re- spectively, the whole accuracy was 90.2% (92/102), with a positive predictive value of 86.7% (39/45) and a negative predictive value of 93.0% (53/57). FFDM gave a sensitivity of 88.4% (38/43), specificity of 83.1% (49/59), and whole accuracy 85.3% (87/102), the positive predictive value and negative predictive value was 79.2% (38/48) and 90.7% (49/54), respectively. All the FNAC-negative cancer cases were suggestive of malignancy by FFDM findings, however, the benign cases which present as equivocal finding by FNA cytology, could not be ruled out the presence of malignancy. Conclusion: FNAC and FFDM both are accurate, effective and economical diagnostic modalities, combined use of these two methods can reduced the misdiag- nosis rate of breast masses.
文摘Ethnic assertions worldwide have assumed different forms ranging from moderate methods of articulation of autonomy to extremist means of violent struggle. Resort to extremism by some sections of an ethnic group usually triggers inter-ethnic conflicts with other groups on the one hand and leads to confrontation with the state on the other. This paper seeks to examine the dynamics of this phenomenon in the context of Bodos, the largest plains tribe of Assam, a State of Northeast India. The paper enquires as to whether extremist politics has met the Bodo aspirations for self-determination or has intensified the conflicts and contradictions within the Bodo society with ramifications for other ethnic groups inhabiting the Bodo-dominated areas. It is also necessary to explore the responses of the Union and State governments to Bodo extremist politics for an understanding of the conflict management process.
文摘AIM: To study the patients with main pancreatic duct dilation on computed tomography (CT) and thereby to provide the predictive criteria to identify patients at high risk of significant diseases, such as pancreatic cancer, and to avoid unnecessary work up for patients at low risk of such diseases. METHODS: Patients with dilation of the main pancreatic duct on CT at Emory University Hospital in 2002 were identified by computer search. Clinical course and ultimate diagnosis were obtained in all the identified patients by abstraction of their computer database records. RESULTS: Seventy-seven patients were identified in this study. Chronic pancreatitis and pancreatic cancer were the most common causes of the main pancreatic duct dilation on CT. Although the majority of patients with isolated dilation of the main pancreatic duct (single duct dilation) had chronic pancreatitis, one-third of patients with single duct dilation but without chronic pancreatitis had pancreatic malignancies, whereas most of patients with concomitant biliary duct dilation (double duct dilation) had pancreatic cancer. CONCLUSION: Patients with pancreatic double duct dilation need extensive work up and careful followup since a majority of these patients are ultimately diagnosed with pancreatic cancer. Patients with single duct dilation, especially such patients without any evidence of chronic pancreatitis, also need careful follow-up since the possibility of pancreatic malignancy, including adenocarcinoma and intraductal papillary mucinous tumors, is still high.
基金supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No. KZCX2-YW-409)
文摘The comparative studies on micromorphological features in diagnostic horizons of Stagnic Anthrosols, Ustic Ferrosols and Ustic Vertosols in southwestern China were conducted to underpin the rationale for Chinese Soil Taxonomy. The following findings were explored: (1) Stagnic Anthrosols had the specific micromorphological features, e.g., the humic formation in anthrostagnic epipedon, the platy structures in plow subhorizon, the secondary formation of ferromanganese and the weakly optical-orientation clay domains in hydragric horizon, etc.: (2) The groundmasses of ferric horizon in Ustic Ferrosols appeared in hue of 2.5YR or redder, and had pellicular grain structure; (3) Ustic Vertosols had a crust horizon (Acr), and crack structure dominated in Acr and angular blocky structure in disturbed horizon; (4) Because of the distinct differences in micromorphological features among these three soils, the specific micromorphological features might be employed as diagnostic horizons to differentiate soils while the quantifiable micromorphological features might potentially be selected as diagnostic indices for Chinese soil taxonomic classification.
基金Supported by The VA Boston Healthcare System and NIH grants R01-CA75289-14,to Fujimoto JG and Mashimo HK99-EB010071-01A1,to Zhou C+2 种基金Air Force Office of Scientific Research contract FA9550-10-1-0063,to Fujimoto JGMedical Free Electron Laser Program contract FA9550-10-1-0551,to Fujimoto JGthe MIT/CIMIT Medical Engineering Fellowship,to Tsai TH
文摘AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP.
文摘D.H.Lawrence is a great writer and Woman in Love is considered as his masterpiece and one of the undoubted classic ofthe 20tb century. Through his flexible application of symbolism, the novel is presented with fragmentary scenes instead of the usual plots, and a lot of separate and unrelated images are employed to reflect the mental conflicts among the major characters. By analyzing the symbolism in this paper, the author hopes to find the importance of symbolism in strengthening the distinct characteristics, enhancing the development of the plot, and hence the emphasis of the theme of the novel.
文摘This article is one of the serial studies oll the characteristics of the molecular structure for dystrophin gene in Chinese. By using the entire dystrophin cDNA (14 kb) as a probe- the number and RFLPs of Bgl Ⅱ exon-containing fragments of the dystrophin gene were analysed. Four new Bgl Ⅱ fragments were found, two of them (3.7 and 6.2 kb) detected by comparing the hybridization patterns with cDNA1-2a. 1a and 2a, one (9.3 kb) from the hybridization pattern with cDNA 9 by lengthening migrating distance of DNA fragments in electrophoresis. and another one (4.0 kb) by comparing the patterns with cDNA 11-14,11a- 11b’ 11c-12a and 14. The results indicated that the number of Bgl Ⅱ exon-containing fragments should be 59 rather than 55 reported previously, which laid the foundation of the Bgl Ⅱ partial restriction map for dystrophin gene. Three of the four RFLPs found in Caucacian appear in the hybridization patterns of three subclones, i.e.cDNA 2b-3. cDNA 4-5, and cDNA 5b-7.’ The values of expected heterozygote frequency (EHF) were 0.33, 0.33and 0.40 and the observed heterozygote frequency (OHF)were 0.40. 0.40 and 0.48 respectively. Meanwhile, two new rare allelic fragments (15 kb) were found in RFLPs from Bgl Ⅱ/2b-3 and Bgl Ⅱ/4-5a patterns respectively. These Bgl Ⅱ RFLPs and four XbaI RFLPs documented in our laboratory, have been used to detect the carrier in 7 DMDfamilies and 1 BMD family. Of the 69 individuals from the 8 families- 11 females were diagnosed as the carriers with DMD mutation, 4 females as the doubtful carriers, 12 females were defined as normal genotype and 2 females as probably normal. The results suggest that the carrier testing method based on dosage intensity analysis and genotype analysis by using dystrophin cDNA as a probe will be more sensitive and accurate.
基金sponsored by the State-level Public Welfare Scientific Research Courtyard Basic Scientific Research Program,Institute of Crustal Dynamics,CEA(ZDJ2010-19)the Joint Earthquake Science Foundation,China (606037)
文摘Located at the west of the Linfen basin, the Luoyunshan piedmont fault zone controls the western boundary of the basin. According to the measurements of the terraces in eight gullies along the Luoyunshan fault zone, five levels of terraces, namely T1~T5 have developed in these gullies. The heights of terraces T1, T2, T3, T4 and T5 are about 3m, 8~10m, about 20m, about 30m and 40~50m, respectively. The dating data of the terraces and investigation of the faulted landforms show that the Luoyunshan fault zone has experienced much activity since the Late Quaternary. The uplift rate of the terraces was 0.41mm/a since the Middle-Late Pleistocene, and 0.75mm/a since the Holocene. The increasing trend of uplift rate of the terraces along the Luoyunshan fault zone from the Middle-Late Pleistocene to Holocene indicates the tendency of gradual tectonic uplift of the fault zone since the late Quaternary. This is in good agreement with the increasing trend of subsidence rate of the Linfen basin from the Late Pleistocene to Holocene.
文摘Despite great efforts in experimental and clinical research, the prognosis of pancreatic cancer (PC) has not changed significantly for decades. Detection of pre-invasive lesions or early-stage PC with small resectable cancers in asymptomatic individuals remains one of the most promising approaches to substantially improve the overall outcome of PC. Therefore, screening programs have been proposed to identify curable lesions especially in individuals with a familial or genetic predisposition for PC. In this regard, Canto et al recently contributed an important article comparing computed tomography, magnetic resonance imaging, and endoscopic ultrasound for the screening of 216 asymptomatic high-risk individuals (HRI). Pancreatic lesions were detected in 92 of 216 asymptomatic HRI (42.6%). The high diagnostic yield in this study raises several questions that need to be answered of which two will be discussed in detail in this commentary: First: which imaging test should be performed? Second and most importantly: what are we doing with incidentally detected pancreatic lesions? Which ones can be observed and which ones need to be resected?