乙交酯/丙交酯/己内酯三元共聚物的合成及表征

A series of tri\|component copolyesters composed of glycolide/lactide/caprolactone (PGLC) were obtained by bulk ring\|opening copolymerization of glycolide(GA),L\|lactide (L\|LA) and caprolactone(CL) with Sn(Oct)\-2 as catalyst for the purpose of biomedical applications.Structure of the PGLC copolyester was characterized by means of GPC,\{\}\+1H\|NMR,DSC and X\|ray diffractometry techniques.It was found that the obtained polymer was a pure copolymer that consisting of no other side\|produced polymers and the copolyester was a random copolymer that presented an amorphous structure in a large range of composition.The hydrophilicity and degradation rate of the copolyester were also studied in detail and it was found that the hydrophilicity and hydrolysis rate were improved by increasing the amount of GA.The mechanical properties of the PGLC copolyester were identified by measuring the tensile strength and the elongation at break.The elongation of the copolyester could be improved by introducing CL to the PLGA.That the PGLC copolyester was a potential biomedical material was suggested.

L-丙交酯-乙交酯-ε-己内酯共聚物模压工艺的正交设计

以L-丙交酯、乙交酯和ε-己内酯为原料开环聚合合成三元共聚物PLLGC。通过正交试验设计研究了预热温度、模压压力、模压温度、模压时间等因素对PLLGC模压材料性能的影响,确定了PLLGC材料最佳的模压工艺。研究了不同因素对PLLGC模压材料的拉伸强度、密度、模压后分子量及分子量分布的影响,通过极差分析结果表明,PLLGC三元共聚物的最佳模压工艺条件:预热温度为150℃,模压压力为8 MPa,模压温度为100℃,模压时间为10 min。

LLA/GA/ε-CL摩尔比对三元共聚物性能的影响

辛酸亚锡为催化剂,采用本体开环聚合方法,合成了一组不同摩尔比的L-丙交酯/乙交酯/ε-己内酯(LLA/GA/CL)三元共聚物。通过GPC、1H-NMR、DSC和XRD测试,研究了摩尔比对共聚物分子量及其分布、热性能和结晶性能的影响。结果表明共聚物组成摩尔比与投料摩尔比基本一致,共聚物玻璃化转变温度(Tg)随LLA和CL含量增加分别呈现升高和降低趋势,并且当LLA含量增加至77 mol%,即LLA/GA摩尔比85∶15时,共聚物表现出明显的部分结晶性。

PGLC对小鼠致畸实验研究

观察了乙交酯 -L -丙交酯 -ε -己内酯三元无规共聚物材料 (PGLC)对昆明种小鼠孕期和胎鼠的影响。结果表明 ,PGLCA组 (10 0 0mg/kg)、B组 (5 0 0mg/kg)、C组 (2 5 0mg/kg)各组孕鼠和胎鼠各项指标与阴性对照组 (C- ,PBS液每日 0 .5ml/鼠 )差异无显著性 (P >0 .0 5 ) ,与阳性对照组 (C+,CP ,14mg/kg)差异有高度显著性 (P <0 .0 1)。PGLC剂量在 10 0 0～ 2 5 0mg/kg范围内对小鼠生殖能力和胎鼠发育无明显影响。