鹿角治疗乳癖症的研究 Ⅱ.鹿角提取物抑制乳腺增生机制的研究

己烯雌酚所致乳腺增生大鼠ｉｇ和ｓｃ鹿角提取物对血中催乳素ｐｒｏｌａｃｔｉｎ（ＰＲＬ）升高有抑制作用，尤其皮下给药最为明显。角叉菜胶和己烯雌酚两种炎症模型都伴有血中ＰＲＬ含量的升高，鹿角提取物对其ＰＲＬ升高均有抑制作用。本文证明，鹿角提取物抑制ＰＲＬ升高的机制可能通过升高脑多巴胺（ＤＡ）含量。

鹿角治疗乳癖症的研究Ⅰ.鹿角提取物的抗炎作用

马鹿鹿角提取物能抑制右旋糖酐和二甲苯所致急性渗出性炎症，对慢性肉芽组织增生性炎症也有明显的抑制作用，对组胺、５ＨＴ。

对乳癖症病因的新认识

乳癖症是发生在女性乳房部的一种慢性非炎性病变。不同年龄的妇女,皆可发生,本病相当于现代医学中因卵巢内分泌功能紊乱或乳腺组织对卵巢激素反应性异常而产生组织结构上改变所导致的乳腺结构不良症。病理分类上的乳痈症。

乳癖症配合光电离子治疗仪治疗乳腺增生病临床观察

目的观察乳癖症配合光电离子治疗仪治疗乳腺增生病的临床疗效。方法 344例乳腺增生病患者,随机分为治疗组140例和对照Ⅰ组104例及对照Ⅱ组100例。治疗组采用乳癖症配合光电离子治疗仪治疗,对照Ⅰ组采用生理盐水配合光电离子治疗仪治疗。对照Ⅱ组将乳癖症涂抹在乳腺增生明显的部位,用手顺时针按摩10 min,至乳房微红微热为止。治疗20-30 d后观察疗效。结果治疗组总有效率（124/140）88.6%;对照Ⅰ组总有效率（64/104）61.5%;对照Ⅱ组总有效率（56/100）56.0%。治疗组疗效明显高于对照Ⅰ组和对照Ⅰ组（P〈0.05）。结论乳癖症配合光电离子治疗仪治疗乳腺增生病取得较好的治疗效果,值得临床推广应用。

乳癖症的中医药治疗研究

目的：探讨中医药治疗乳癖症的临床疗效。方法：从本院抽取2013年1月∽2013年12月收治的64例乳癖症患者，按照他们入院就诊顺序将他们随机分组，分别为观察组及对照组，每组各32例，给予观察组中医药进行治疗，处方如下：当归、赤芍、炮山甲、瓜蒌各15g，柴胡、枳壳、桔梗、元胡、甘草各12g，给予对照组乳癖消进行治疗，各治疗3个月后，观察2组患者的临床疗效。结果：通过不同方法治疗后，观察组患者的总有效率为90．6％，对照组患者的总有效率为78．1％，2组疗效比较存在明显差异性，具有统计学意义（P＜0．05）。结论：中医药治疗乳癖症临床疗效确切，安全可靠，副作用少，值得进一步推广并应用。

Rupi Sanjie Xiaotong Plaster in Treating Breast Hyperplasia of Liver Stagnation and Phlegm Coagulation Pattern

Objective:To observe the clinical efcacy and safety of external application of Rupi Sanjie Xiaotong Plaster(乳癖散结消痛膏,RPSJXTP)in treating breast hyperplasia of liver stagnation and phlegm coagulation pattern.Methods:Totally 72 female patients with breast hyperplasia of liver stagnation and phlegm coagulation pattern admitted to the First Hospital Affiliated to Henan University of Chinese Medicine were enrolled by ran-domized,single-blind,placebo-controlled research method,and were divided into the treatment group(36 ca-ses)and the control group(36 cases)according to computer random number method.The treatment group were given RPSJXTP,while the control group were gi ven placebo plaster.The course of treatment in both groups was 8 weeks.The breast pain score,breast color ultrasound score,lump score,depression score,and Chinese medicine syndrome score were compared between the two groups at different times.The levels of estra-diol(E_(2)),progesterone(P)and pituitary prolactin(PRL)were detected and the adverse reactions of two groups were observed during the treatment of both groups.Results:Before treatment,there was no significant difference in total breast pain score,breast color ultrasound score,lump score,depression score and levels of serum P,E_(2)and PRL between the two groups(P>0.05);compared with previous treatment,the total breast pain score,breast color ultrasound score,lump score,and depression score significantly decreased in the treat-ment group(P<0.05),and the total breast pain score and depression score of the control group significantly declined(P<0.05);compared with control group,the total breast pain score,breast color ultrasound score,lump score,and depression score significantly decreased after treatment in the treatment group(P<0.05).The improvement rate of Chinese medicine syndromes and the clinical efective rate in the treatment group were higher than those in the control group(P<0.05).There were no serious systemie adverse reactions during the treatment in both groups.Local pruritus occurred in 3 cases in the treatment group and 1 case in the control group.Conclusion:RPSJXTP is effective in treating breast hyperplasia of liver stagnation and phlegm coagula-tion pattern.It can effectively relieve the breast pain which will not recur after stopping of drug use,which can reduce the color ultrasound score,lump score,and depression score of the patients and improve Chinese medi-cine syndromes without serious adverse reactions.