4-dimethylpyridine（DMAP） was used as catalyst for preparing benzimidazolyl phenoxyacetic acid O-acetyllactopyranosyl saccharide carboxylate and triethylamine（Et3N） was used as deacid reagent.Three saccharide carbo...4-dimethylpyridine（DMAP） was used as catalyst for preparing benzimidazolyl phenoxyacetic acid O-acetyllactopyranosyl saccharide carboxylate and triethylamine（Et3N） was used as deacid reagent.Three saccharide carboxylates were synthesized from saccharide carboxylation at room temperature in the system of DMAP/Et3N with nitro-containing,trifluoromethyl benzimidazolyl phenoxyacetic acid with as lead compounds.The catalytic mechanism of DMAP/Et3N was discussed.The results showed that DMAP is a effective catalyst.The yields can reach over 52.7%.The test indicated that the compounds showed better antiviral activity against tobacco mosaie virus（TMV）.展开更多
Fermented whey （a by-product from tofu industry） has been used as a coagulant in tofu manufactures in Indonesia. This research aimed to study effects of fermented whey on coagulation efficiency and physicochemical c...Fermented whey （a by-product from tofu industry） has been used as a coagulant in tofu manufactures in Indonesia. This research aimed to study effects of fermented whey on coagulation efficiency and physicochemical characteristics of tofu, compared to other acid coagulants （acetic acid and glucono-delta-lactone （GDL）） and salt coagulants （calcium sulfate and natural gypsum）. A randomized block design with a single factor was used in this research. Fermented whey could be used as coagulant in tofu manufacturing. Physicochemical characteristics of tofu from fermented whey were not significantly difference compared to tofu from calcium salt and acid coagulants. Coagulation efficiencies （CF, TSIL TPR and TB~） of fermented whey are lower than that from calcium salt coagulants （calcium sulphate and natural gypsum）. Fermented whey showed no significant differences in tofu properties and parameters of coagulation process, compared to GDL and acetic acid.展开更多
目的:研究盐酸西替利嗪片的有关物质,探讨生产工艺存在的问题,为提高药品质量提供参考。方法:对18家企业生产的盐酸西替利嗪片,以HPLC法进行有关物质检查,对主要杂质进行定性定量研究,色谱条件:采用CAPCELL PAK C18(4.6 mm×250 mm,...目的:研究盐酸西替利嗪片的有关物质,探讨生产工艺存在的问题,为提高药品质量提供参考。方法:对18家企业生产的盐酸西替利嗪片,以HPLC法进行有关物质检查,对主要杂质进行定性定量研究,色谱条件:采用CAPCELL PAK C18(4.6 mm×250 mm,5μm)色谱柱,以0.2%四丁基硫酸氢铵与0.3%一水合磷酸二氢钠溶液(用1 mol·L^-1氢氧化钠调pH至2.8±0.05)和甲醇为流动相,梯度洗脱,检测波长为232nm。对其中的未知杂质经分离制备后,采用色谱-质谱(MSn)技术测定离子准确质量并分析离子特征,确证有关物质结构;建立原辅料相容性试验确定杂质的产生途径。结果:盐酸西替利嗪中可能存在10个杂质,18家企业的盐酸西替利嗪片中检出的主要杂质为西替利嗪乙酯与西替利嗪乳糖酯,其含量与盐酸西替利嗪片的处方工艺高度相关。结论:目前国产盐酸西替利嗪片的处方工艺不合理,活性成分与辅料不相容。应从处方设计和改造入手,控制盐酸西替利嗪片的有关物质,提高本品质量疗效和临床用药安全。展开更多
文摘4-dimethylpyridine（DMAP） was used as catalyst for preparing benzimidazolyl phenoxyacetic acid O-acetyllactopyranosyl saccharide carboxylate and triethylamine（Et3N） was used as deacid reagent.Three saccharide carboxylates were synthesized from saccharide carboxylation at room temperature in the system of DMAP/Et3N with nitro-containing,trifluoromethyl benzimidazolyl phenoxyacetic acid with as lead compounds.The catalytic mechanism of DMAP/Et3N was discussed.The results showed that DMAP is a effective catalyst.The yields can reach over 52.7%.The test indicated that the compounds showed better antiviral activity against tobacco mosaie virus（TMV）.
文摘Fermented whey （a by-product from tofu industry） has been used as a coagulant in tofu manufactures in Indonesia. This research aimed to study effects of fermented whey on coagulation efficiency and physicochemical characteristics of tofu, compared to other acid coagulants （acetic acid and glucono-delta-lactone （GDL）） and salt coagulants （calcium sulfate and natural gypsum）. A randomized block design with a single factor was used in this research. Fermented whey could be used as coagulant in tofu manufacturing. Physicochemical characteristics of tofu from fermented whey were not significantly difference compared to tofu from calcium salt and acid coagulants. Coagulation efficiencies （CF, TSIL TPR and TB~） of fermented whey are lower than that from calcium salt coagulants （calcium sulphate and natural gypsum）. Fermented whey showed no significant differences in tofu properties and parameters of coagulation process, compared to GDL and acetic acid.
