目的探讨以梭形细胞/肉瘤样成分为主的乳腺化生性癌(metaplastic breast carcinoma with dominant spindle cell/sarcoma-toid component,MBCSC)的临床病理及免疫表型特点。方法复习15例MBCSC的临床病理资料,并对其中12例肿瘤进行免疫...目的探讨以梭形细胞/肉瘤样成分为主的乳腺化生性癌(metaplastic breast carcinoma with dominant spindle cell/sarcoma-toid component,MBCSC)的临床病理及免疫表型特点。方法复习15例MBCSC的临床病理资料,并对其中12例肿瘤进行免疫组化染色(抗体包括上皮标记、肌上皮标记和肿瘤标记物)。同时就腋淋巴结状态,ER、PR和Her2的表达与浸润性导管癌做简要比较。结果本组MBCSC患者平均年龄41岁,均因发现乳腺包块就诊。多数肿瘤呈界限清楚的结节状。镜下8例肿瘤完全由梭形/肉瘤样细胞构成,6例以梭形/肉瘤样细胞为主伴少量浸润性导管癌(invasive ductal carcinoma IDC)成分,1例伴少量导管原位癌。肿瘤显示中-高级别组织学改变。11/12例(91.7%)MBCSC的梭形细胞/肉瘤样成分至少表达一种上皮标记,全部病例均至少表达一种肌上皮标记。本组MBCSC的腋淋巴结转移率和ER、PR、Her2的表达均低于对照组。结论 MBCSC在独特的组织病理学基础上呈现出肌上皮分化,其生物学特性如腋淋巴结状态和肿瘤标记物的表达与浸润性导管癌有所不同,提示其可以作为独立的病理亚型。系列上皮和肌上皮标记的免疫组化染色有助于MBCSC的病理诊断。展开更多
乳腺梭形细胞癌(spindle cell carcinoma)是乳腺化生性癌(metaplastic breast carcinoma)的一种亚型,是一种比较罕见的组织学类型。乳腺梭形细胞癌发生率极低,占所有乳腺癌的0.024%~0.5%[1]。临床表现与典型乳腺癌相比无明显特异性,临...乳腺梭形细胞癌(spindle cell carcinoma)是乳腺化生性癌(metaplastic breast carcinoma)的一种亚型,是一种比较罕见的组织学类型。乳腺梭形细胞癌发生率极低,占所有乳腺癌的0.024%~0.5%[1]。临床表现与典型乳腺癌相比无明显特异性,临床易漏诊或误诊。展开更多
乳腺化生性癌(metaplastic breast carcinoma,MBC)是一种较少的乳腺恶性肿瘤,其治疗效果一般,预后较差。我院收治1例乳腺化性鳞状细胞癌,查阅相关文献结合其病历资料综合讨论本病临床病理特征,报告如下。1病历报告患者,女,53岁,已绝经,...乳腺化生性癌(metaplastic breast carcinoma,MBC)是一种较少的乳腺恶性肿瘤,其治疗效果一般,预后较差。我院收治1例乳腺化性鳞状细胞癌,查阅相关文献结合其病历资料综合讨论本病临床病理特征,报告如下。1病历报告患者,女,53岁,已绝经,主因发现左乳肿物7d于2022年7月4日入院。查体:双乳对称,皮肤无红肿、破溃,无橘皮样改变,乳头无内陷、无溢血溢液。于左乳外下象限4点钟处可触及一肿物,大小约1.5cm×1.2cm,质硬,界尚清,表面欠光滑,活动度可,有压痛,与皮肤稍有粘连。双侧腋下及锁骨上、下未触及明显肿大淋巴结。辅助检查:B超显示左乳外下象限4点钟方向可见大小约1.9cm×1.5cm×1.7 cm的低回声,界尚清,形态欠规整,彩色多普勒超声CDFI显示未见明显异常血流信号。B超诊断:左乳低回声结节(BI-RADS 4b级)。展开更多
Squamous cell carcinoma is one of the most common primary cutaneous carcinomas but on rare occasion, metastatic squamous cell carcinoma from a distant site or solid organ can present as a cutaneous lesion. Most metast...Squamous cell carcinoma is one of the most common primary cutaneous carcinomas but on rare occasion, metastatic squamous cell carcinoma from a distant site or solid organ can present as a cutaneous lesion. Most metastases occur as dermal nodules or involve the dermal lymphatics, but when they are intimately associated with the epidermis, distinguishing the lesion as primary or metastatic may be extremely difficult and usually requires a clinical history or high index of suspicion. A 71- year- old woman presented with multiple eruptive nodules over her chest, flank, and back. Histologically the lesions appeared to be arising from the surface epithelium and consisted of atypical, predominantly spindle cells, some of which streamed off of the epidermis. Following the initial evaluation, a history of breast carcinoma with subsequent radiation therapy and ultimate mastectomy was obtained, and the original breast biopsy and mastectomy material was reviewed. After performing additional studies, it became clear that the origin of the carcinomas was metastatic from an underlying metaplastic breast carcinoma.展开更多
目的探讨乳腺纤维瘤病样梭形细胞癌(fibrom atosis-like sp ind le cell carc inom a,FLSCC)临床病理特征。方法对3例FLSCC病例进行光镜观察和免疫组化染色〔CK、CK(34βE12)、vim entin、SMA、ER、PR、K i-67、c-erbB-2〕。结果3例均...目的探讨乳腺纤维瘤病样梭形细胞癌(fibrom atosis-like sp ind le cell carc inom a,FLSCC)临床病理特征。方法对3例FLSCC病例进行光镜观察和免疫组化染色〔CK、CK(34βE12)、vim entin、SMA、ER、PR、K i-67、c-erbB-2〕。结果3例均为女性,年龄分别为47、53、56岁,均可触及乳腺肿块。肿瘤境界清楚,但镜下边缘呈浸润性。肿瘤主要是梭形细胞、多边形细胞、少量的管状腺体及鳞上皮巢混合,间质纤维明显增生伴胶原化,细胞成束状排列或散在分布,似纤维瘤病样改变。梭形细胞分化良好,异型性不明显,部分区域细胞较丰富,其间聚集的上皮簇或片状多边形细胞核有轻度异型,可见少数核分裂象。多边形细胞与梭形细胞有移行。病变中亦可见淋巴细胞、浆细胞聚集浸润。上皮细胞、多边形细胞及部分梭形细胞CK(34βE12)、CK(AE1/AE3)阳性,CK阴性的梭形细胞表达vim entin、SMA。3例均行肿块切除,其中1例,术后4个月复发,再行乳腺根治术。结论乳腺(纤维瘤病样)梭形细胞癌是一种少见的、低度恶性肿瘤,诊断需依赖免疫组化标记并与乳腺其它梭形细胞肿瘤相鉴别。展开更多
文摘乳腺梭形细胞癌(spindle cell carcinoma)是乳腺化生性癌(metaplastic breast carcinoma)的一种亚型,是一种比较罕见的组织学类型。乳腺梭形细胞癌发生率极低,占所有乳腺癌的0.024%~0.5%[1]。临床表现与典型乳腺癌相比无明显特异性,临床易漏诊或误诊。
文摘乳腺化生性癌(metaplastic breast carcinoma,MBC)是一种较少的乳腺恶性肿瘤,其治疗效果一般,预后较差。我院收治1例乳腺化性鳞状细胞癌,查阅相关文献结合其病历资料综合讨论本病临床病理特征,报告如下。1病历报告患者,女,53岁,已绝经,主因发现左乳肿物7d于2022年7月4日入院。查体:双乳对称,皮肤无红肿、破溃,无橘皮样改变,乳头无内陷、无溢血溢液。于左乳外下象限4点钟处可触及一肿物,大小约1.5cm×1.2cm,质硬,界尚清,表面欠光滑,活动度可,有压痛,与皮肤稍有粘连。双侧腋下及锁骨上、下未触及明显肿大淋巴结。辅助检查:B超显示左乳外下象限4点钟方向可见大小约1.9cm×1.5cm×1.7 cm的低回声,界尚清,形态欠规整,彩色多普勒超声CDFI显示未见明显异常血流信号。B超诊断:左乳低回声结节(BI-RADS 4b级)。
文摘Squamous cell carcinoma is one of the most common primary cutaneous carcinomas but on rare occasion, metastatic squamous cell carcinoma from a distant site or solid organ can present as a cutaneous lesion. Most metastases occur as dermal nodules or involve the dermal lymphatics, but when they are intimately associated with the epidermis, distinguishing the lesion as primary or metastatic may be extremely difficult and usually requires a clinical history or high index of suspicion. A 71- year- old woman presented with multiple eruptive nodules over her chest, flank, and back. Histologically the lesions appeared to be arising from the surface epithelium and consisted of atypical, predominantly spindle cells, some of which streamed off of the epidermis. Following the initial evaluation, a history of breast carcinoma with subsequent radiation therapy and ultimate mastectomy was obtained, and the original breast biopsy and mastectomy material was reviewed. After performing additional studies, it became clear that the origin of the carcinomas was metastatic from an underlying metaplastic breast carcinoma.
文摘目的探讨乳腺纤维瘤病样梭形细胞癌(fibrom atosis-like sp ind le cell carc inom a,FLSCC)临床病理特征。方法对3例FLSCC病例进行光镜观察和免疫组化染色〔CK、CK(34βE12)、vim entin、SMA、ER、PR、K i-67、c-erbB-2〕。结果3例均为女性,年龄分别为47、53、56岁,均可触及乳腺肿块。肿瘤境界清楚,但镜下边缘呈浸润性。肿瘤主要是梭形细胞、多边形细胞、少量的管状腺体及鳞上皮巢混合,间质纤维明显增生伴胶原化,细胞成束状排列或散在分布,似纤维瘤病样改变。梭形细胞分化良好,异型性不明显,部分区域细胞较丰富,其间聚集的上皮簇或片状多边形细胞核有轻度异型,可见少数核分裂象。多边形细胞与梭形细胞有移行。病变中亦可见淋巴细胞、浆细胞聚集浸润。上皮细胞、多边形细胞及部分梭形细胞CK(34βE12)、CK(AE1/AE3)阳性,CK阴性的梭形细胞表达vim entin、SMA。3例均行肿块切除,其中1例,术后4个月复发,再行乳腺根治术。结论乳腺(纤维瘤病样)梭形细胞癌是一种少见的、低度恶性肿瘤,诊断需依赖免疫组化标记并与乳腺其它梭形细胞肿瘤相鉴别。
