Objective： To investigate the potential clinical value of Chinese ink as a tracer in dye-directed sentinel lymph node biopsy. Methods： Forty-two female rabbits were randomly divided into 7 groups. The breast drainag...Objective： To investigate the potential clinical value of Chinese ink as a tracer in dye-directed sentinel lymph node biopsy. Methods： Forty-two female rabbits were randomly divided into 7 groups. The breast drainage lymphatic vessels and nodes in axilla were exposed by surgery. Under the papillae of the second pair of breast, 0.1 mL Chinese ink dilution at concentrations of 0.1%, 1%, 10%, 50% and 100% and isosulfan blue （IB, 1.0%） were injected. The movement of ink in lymphatic chain was investigated, and the number of stained nodes and their staining and washout time ware recorded. The first stained lymph node that was followed through lymphatic drainage was identified as the sentinel lymph node （SLN）. The SLNs were dissected and prepared for histological observation 5 rain, 1 h and 2 weeks after stained. Blood samples were harvested and tested before and 2 weeks after injection. The hearts, lungs, livers and kidneys were dissected after a period of post-operation observation and sent for pathologic examination. Results： No obvious differences were observed among the staining time of SLNs and the second lymph node using ink at different concentrations （P〉0.05）. But they were obviously longer than that of IB （P〈0.05）. The mean number of nodes obtained was nearly the same （P〉0.05）. It was too light for gross visual inspection when nodes were stained by ink at the concentration of 0.1%. Nodes stained by IB faded 33.9 rain after stained. And carbon staining seemed permanent without any visible decline after 2 weeks. Carbon particles were found to be in the sinus of lymph nodes that were obtained 5 rain after stained, and then was phagocytosed by macrophages （MФ） 1 h later. The density of carbon obscured the microscopic observation of lymph nodes when they were stained using Chinese ink at concentration of higher than 20.0%. No obvious changes were investigated in blood test and vital organ pathologic examination. Conclusion： Chinese ink is potentially a novel type of dye tracer in SLN biopsy.展开更多
Objective: To investigate the correlativity between mammographic features and c-erbB-2 of breast cancer. Meth- ods: The mammographic features of 165 patients, including calcification, distinct, esion concentration, br...Objective: To investigate the correlativity between mammographic features and c-erbB-2 of breast cancer. Meth- ods: The mammographic features of 165 patients, including calcification, distinct, esion concentration, breast cysitic hyperplasia accompanied, were studied comparatively with c-erbB-2 gene stained with immunohistochemical technique. Results: Of 165 cases, calcification impression was 84 cases (50.91%), indistinct 80 cases (48.40%), lesions were concentrated of 87 case (52.73%), accompanied breast cysitic hyperplasia 85 cases (51.52%). Conclusion: Mammographic features of breast cancer could show the status of c-erbB-2, the positive chance is higher with calcification, indistinct, lesion concentration and accompa- nied breast cysitic hyperplasia.展开更多
In this study different types of customized phantoms were used to examine a long term reproducibility check of a full field digital mammography system. These phantoms can be distinguished into three types： a PMMA （p...In this study different types of customized phantoms were used to examine a long term reproducibility check of a full field digital mammography system. These phantoms can be distinguished into three types： a PMMA （polimethylmethacrylate） object for an easy signal-to-noise ratio measurement in a defined region, a phantom with particular details of various dimensions （TORMAS） and a phantom for a contrast-detail analysis （CDMAM）. In our center the ARTINIS ANALYZER software has been used since 2011 to weekly perform a CDMAM phantom analysis. This soitware is based on the original CDCOM algorithm suggested by the EUREF, the European Reference Organization for assured quality breast screening and diagnostic services. However the CDMAM phantom is a contrast-detail object designed for image quality type tests and not for long term reproducibility control. Since 2013, as suggested by the guidelines of Veneto region, a TORMAS weekly acquisition and analysis of data has also been performed. The purpose of this study is to discuss the data obtained by using the two different detail phantoms, CDMAM and TORMAS. These results can provide some correlations among the analyzed parameters comparing them with the ones emerging from the PMMA phantom analysis. The study reveals that the basic PMMA phantom is the object that provides the necessary information about the stability of the exposure parameters and the reproducibility of a mammographic equipment in terms of image quality indexes.展开更多
Objective: To evaluate the value of identifying and diagnosing mammary carcinoma and non-lactation mastitis lump (NLM) by multicolor Doppler ultrasonography. Methods: We compared and analyzed the examination results o...Objective: To evaluate the value of identifying and diagnosing mammary carcinoma and non-lactation mastitis lump (NLM) by multicolor Doppler ultrasonography. Methods: We compared and analyzed the examination results of 69 cases of mammary carcinoma proved by surgical pathology and 22 cases of NLM before surgery by multicolor Doppler ultra-sonography. Results: The detection rates of mammary carcinoma and NLM focus by ultrasonic examining were 100%. The shape, envelope, foul line, blood stream between sound and image of two diseases were similar. Of the two diseases, the representation with slight calcification in lump, lower echo in low echo, bloodstream distribution and resistance were different. Conclusion: By analyzing the sound and image representation of mammary lump, we find color Doppler ultrasonography has significant value in identifying and diagnosing mammary carcinoma and non-lactation mastitis lump.展开更多
Lapatinib is an inhibitor of the tyrosine kinases of human epidermal growth factor receptor type 2 (HER2) and epidermal growth factor receptor type 1, with clinical activity in HER2-positive metastatic breast cancer. ...Lapatinib is an inhibitor of the tyrosine kinases of human epidermal growth factor receptor type 2 (HER2) and epidermal growth factor receptor type 1, with clinical activity in HER2-positive metastatic breast cancer. We present here a 60 year-old patient with metastatic breast cancer who presented with jaundice and increased serum aminotransferase levels and who had been treated with lapatinib for the previous 14 days. Laboratory tests excluded other causes of acute liver injury. Liver biopsy revealed lesions compatible with drug-induced hepatotoxicity. Bilirubin and liver enzymes returned to normal within three months of lapatinib discontinuation. Lapatinib should be included among the causes of druginduced hepatitis.展开更多
基金This project was supported by a grant of Science and Technique Development Project Foundation of Jiangsu Province (No. BS2004040) and a grant from 135 Project of Jiangsu Province.
文摘Objective： To investigate the potential clinical value of Chinese ink as a tracer in dye-directed sentinel lymph node biopsy. Methods： Forty-two female rabbits were randomly divided into 7 groups. The breast drainage lymphatic vessels and nodes in axilla were exposed by surgery. Under the papillae of the second pair of breast, 0.1 mL Chinese ink dilution at concentrations of 0.1%, 1%, 10%, 50% and 100% and isosulfan blue （IB, 1.0%） were injected. The movement of ink in lymphatic chain was investigated, and the number of stained nodes and their staining and washout time ware recorded. The first stained lymph node that was followed through lymphatic drainage was identified as the sentinel lymph node （SLN）. The SLNs were dissected and prepared for histological observation 5 rain, 1 h and 2 weeks after stained. Blood samples were harvested and tested before and 2 weeks after injection. The hearts, lungs, livers and kidneys were dissected after a period of post-operation observation and sent for pathologic examination. Results： No obvious differences were observed among the staining time of SLNs and the second lymph node using ink at different concentrations （P〉0.05）. But they were obviously longer than that of IB （P〈0.05）. The mean number of nodes obtained was nearly the same （P〉0.05）. It was too light for gross visual inspection when nodes were stained by ink at the concentration of 0.1%. Nodes stained by IB faded 33.9 rain after stained. And carbon staining seemed permanent without any visible decline after 2 weeks. Carbon particles were found to be in the sinus of lymph nodes that were obtained 5 rain after stained, and then was phagocytosed by macrophages （MФ） 1 h later. The density of carbon obscured the microscopic observation of lymph nodes when they were stained using Chinese ink at concentration of higher than 20.0%. No obvious changes were investigated in blood test and vital organ pathologic examination. Conclusion： Chinese ink is potentially a novel type of dye tracer in SLN biopsy.
基金Supported by a grant from the Science and Technology Bureau, Shen-zhen City (No. 200404025).
文摘Objective: To investigate the correlativity between mammographic features and c-erbB-2 of breast cancer. Meth- ods: The mammographic features of 165 patients, including calcification, distinct, esion concentration, breast cysitic hyperplasia accompanied, were studied comparatively with c-erbB-2 gene stained with immunohistochemical technique. Results: Of 165 cases, calcification impression was 84 cases (50.91%), indistinct 80 cases (48.40%), lesions were concentrated of 87 case (52.73%), accompanied breast cysitic hyperplasia 85 cases (51.52%). Conclusion: Mammographic features of breast cancer could show the status of c-erbB-2, the positive chance is higher with calcification, indistinct, lesion concentration and accompa- nied breast cysitic hyperplasia.
文摘In this study different types of customized phantoms were used to examine a long term reproducibility check of a full field digital mammography system. These phantoms can be distinguished into three types： a PMMA （polimethylmethacrylate） object for an easy signal-to-noise ratio measurement in a defined region, a phantom with particular details of various dimensions （TORMAS） and a phantom for a contrast-detail analysis （CDMAM）. In our center the ARTINIS ANALYZER software has been used since 2011 to weekly perform a CDMAM phantom analysis. This soitware is based on the original CDCOM algorithm suggested by the EUREF, the European Reference Organization for assured quality breast screening and diagnostic services. However the CDMAM phantom is a contrast-detail object designed for image quality type tests and not for long term reproducibility control. Since 2013, as suggested by the guidelines of Veneto region, a TORMAS weekly acquisition and analysis of data has also been performed. The purpose of this study is to discuss the data obtained by using the two different detail phantoms, CDMAM and TORMAS. These results can provide some correlations among the analyzed parameters comparing them with the ones emerging from the PMMA phantom analysis. The study reveals that the basic PMMA phantom is the object that provides the necessary information about the stability of the exposure parameters and the reproducibility of a mammographic equipment in terms of image quality indexes.
文摘Objective: To evaluate the value of identifying and diagnosing mammary carcinoma and non-lactation mastitis lump (NLM) by multicolor Doppler ultrasonography. Methods: We compared and analyzed the examination results of 69 cases of mammary carcinoma proved by surgical pathology and 22 cases of NLM before surgery by multicolor Doppler ultra-sonography. Results: The detection rates of mammary carcinoma and NLM focus by ultrasonic examining were 100%. The shape, envelope, foul line, blood stream between sound and image of two diseases were similar. Of the two diseases, the representation with slight calcification in lump, lower echo in low echo, bloodstream distribution and resistance were different. Conclusion: By analyzing the sound and image representation of mammary lump, we find color Doppler ultrasonography has significant value in identifying and diagnosing mammary carcinoma and non-lactation mastitis lump.
文摘Lapatinib is an inhibitor of the tyrosine kinases of human epidermal growth factor receptor type 2 (HER2) and epidermal growth factor receptor type 1, with clinical activity in HER2-positive metastatic breast cancer. We present here a 60 year-old patient with metastatic breast cancer who presented with jaundice and increased serum aminotransferase levels and who had been treated with lapatinib for the previous 14 days. Laboratory tests excluded other causes of acute liver injury. Liver biopsy revealed lesions compatible with drug-induced hepatotoxicity. Bilirubin and liver enzymes returned to normal within three months of lapatinib discontinuation. Lapatinib should be included among the causes of druginduced hepatitis.
