Individual detection significances of small breast epithelial mucin (SBEM) and human mammaglobin (hMAM) expressions in peripheral blood of breast cancer patients

Objective： The aim of the study was to explore the individual detection significances of small breast epithelial mucin （SBEM） and human mammaglobin （hMAM） in peripheral blood （PB） of breast cancer patients. Methods： SBEM and hMAM expressions in PB samples of 109 primary breast cancer patients were detected by flow cytometry （FCM） and RT- PCR. Relationship between the biomarkers＇ expression and prognostic parameters were analyzed. Results： SBEM and hMAM expressions in PB of breast cancer patients were much higher than those of healthy donors and other cancer patients. SBEM and hMAM expressed in 53.2% （50/94） and 39.4% （37/94） cases at stages I-III and expressed in 73.3% （11/15） and 46.7% （7/15） cases at stage IV respectively. SBEM and hMAM mRNA were only detected in PB samples of breast cancer patients, while no expression of them was found in that of healthy donors and other cancer patients. Conclusion： hMAM mRNA detection maybe helpful to predict hematogenous micrometastasis in ER-positive, well-differentiated breast cancers and SBEM mRNA detection maybe helpful to predict hematogenous micrometastasis in ER-negative, poody-differentiated breast cancers.

扩散光对大脑及乳腺的功能成像和监测

在乳腺癌成像、大脑的功能激活及临床研究、癌症治疗监测和肌肉疾病的研究等各种医疗解决方案中,功能性扩散光学成像和组织的光谱学技术逐渐成为一种重要的诊断方法。在简要介绍扩散光学的概念后,回顾了实验室多项近期的临床研究,特别是那些针对乳腺癌和脑功能的研究。乳腺癌研究的核心在于试点性的临床试验,目前已经进展到了对扩散光的定量评估,以用于肿瘤的检测和表征,也有助于癌症治疗检测等衍生问题的解决。扩散光学方法的第二个重要应用是在脑功能和生理学研究领域,这个领域中,组织氧消耗、维管联结和调节效应之间的相互作用甚少为人所知。这一方法在脑研究中的应用将会以多个示例介绍,包括临床上对急性缺血性脑卒中病人的看护等。