Objective Laser-induced myocardial injury was investigated in a canine transmyocardial laser revascularization model.Methods A total of 23 channels were created in the left ventricles of 5 animals with a CO2 laser. ...Objective Laser-induced myocardial injury was investigated in a canine transmyocardial laser revascularization model.Methods A total of 23 channels were created in the left ventricles of 5 animals with a CO2 laser. Four animals were sacrificed immediately and one at week 2. Lactate dehydrogenase and succinate dehydrogenase in channel regions were examined with a Nitro-BT method staining.Results Immediately after the procedure, laser channels and surrounding injured myocardium could be stratified from the center to the border into 5 concentric zones, i.e., vaporized zone, carbonized zone, enzyme-disappeared zone, enzyme-decreased zone and enzyme-concentrated zone. Two weeks later, the phenomenon disappeared.Conclusions Immediately after transmyocardial revascularization, there is a ring of enzyme-concentrated zone at the outermost region of injured myocardium. Two weeks later, enzyme activities of reversibly injured myocytes appear to have recovered.展开更多
Objective:To systematically evaluate the impact of acupuncture on exercise-induced fatigue(EIF).Methods:Scopus,Springer Link,Web of Science,PubMed,Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang...Objective:To systematically evaluate the impact of acupuncture on exercise-induced fatigue(EIF).Methods:Scopus,Springer Link,Web of Science,PubMed,Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP),and China Biology Medicine Disc(CBM)were systematically searched to identify randomized controlled trials(RCTs)studying acupuncture treatment of EIF from the inception till August 2020.The risk of bias in the included studies was assessed using the Cochrane handbook.RevMan 5.3 was used to conduct statistical analysis on the extracted data.Results:A total of 11 RCTs were included for meta-analysis,involving 531 patients.It was revealed that acupuncture produced more significant effects in alleviating subjective fatigue[standardized mean difference(SMD)=-3.08,95%confidence interval(CI)(-4.35,-1.81),P<0.001],increasing the hemoglobin content[weighted mean difference(WMD)=3.89,95%CI(1.37,6.42),P=0.003],reducing the lactate dehydrogenase content[WMD=-10.63,95%CI(-17.67,-3.59),P=0.003],reducing the blood lactic acid content[SMD=-2.65,95%CI(-4.47,-0.83),P=0.004],and down-regulating the levels of serum creatine kinase[SMD=-0.79,95%CI(-1.10,-0.48),P<0.001]and blood urea nitrogen[WMD=-1.47,95%CI(-1.84,-1.11),P<0.001]than the control groups.Conclusion:Based on the existing evidence,acupuncture can be recognized as effective in improving EIF and is worthy of promotion in clinical settings.展开更多
文摘Objective Laser-induced myocardial injury was investigated in a canine transmyocardial laser revascularization model.Methods A total of 23 channels were created in the left ventricles of 5 animals with a CO2 laser. Four animals were sacrificed immediately and one at week 2. Lactate dehydrogenase and succinate dehydrogenase in channel regions were examined with a Nitro-BT method staining.Results Immediately after the procedure, laser channels and surrounding injured myocardium could be stratified from the center to the border into 5 concentric zones, i.e., vaporized zone, carbonized zone, enzyme-disappeared zone, enzyme-decreased zone and enzyme-concentrated zone. Two weeks later, the phenomenon disappeared.Conclusions Immediately after transmyocardial revascularization, there is a ring of enzyme-concentrated zone at the outermost region of injured myocardium. Two weeks later, enzyme activities of reversibly injured myocytes appear to have recovered.
文摘Objective:To systematically evaluate the impact of acupuncture on exercise-induced fatigue(EIF).Methods:Scopus,Springer Link,Web of Science,PubMed,Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP),and China Biology Medicine Disc(CBM)were systematically searched to identify randomized controlled trials(RCTs)studying acupuncture treatment of EIF from the inception till August 2020.The risk of bias in the included studies was assessed using the Cochrane handbook.RevMan 5.3 was used to conduct statistical analysis on the extracted data.Results:A total of 11 RCTs were included for meta-analysis,involving 531 patients.It was revealed that acupuncture produced more significant effects in alleviating subjective fatigue[standardized mean difference(SMD)=-3.08,95%confidence interval(CI)(-4.35,-1.81),P<0.001],increasing the hemoglobin content[weighted mean difference(WMD)=3.89,95%CI(1.37,6.42),P=0.003],reducing the lactate dehydrogenase content[WMD=-10.63,95%CI(-17.67,-3.59),P=0.003],reducing the blood lactic acid content[SMD=-2.65,95%CI(-4.47,-0.83),P=0.004],and down-regulating the levels of serum creatine kinase[SMD=-0.79,95%CI(-1.10,-0.48),P<0.001]and blood urea nitrogen[WMD=-1.47,95%CI(-1.84,-1.11),P<0.001]than the control groups.Conclusion:Based on the existing evidence,acupuncture can be recognized as effective in improving EIF and is worthy of promotion in clinical settings.
