As one with great fame of writing China and Chinese people in war time, Anna Louise Strong, has the experience of communicating with Chinese left-wing writers, viewing their dramas works and reading their novels. From...As one with great fame of writing China and Chinese people in war time, Anna Louise Strong, has the experience of communicating with Chinese left-wing writers, viewing their dramas works and reading their novels. From her perspective, Chinese left-wing literature was featured by its revolution and popularity; Chinese left-wing writers were busy with creating different genres to get every Chinese＇s involvement in the anti-Japanese war in 1930s and participation in the construction of new China in 1940s. Hence, they were multifarious in their identity because they cared more than literature in a turbulent time. From what she presented, China, as a cultural otherness, was the existent utooia that fulfilled her radical nolitical dream of communism.展开更多
China commemorated on September 3,2014 the first official memorial day of the War of Resistance against Japanese Aggression and the anti-fascist war victory.The occasion affirmed the justice of the anti-Japanese war a...China commemorated on September 3,2014 the first official memorial day of the War of Resistance against Japanese Aggression and the anti-fascist war victory.The occasion affirmed the justice of the anti-Japanese war and China’s firm stance in safeguarding the achievements of WWII and maintaining world peace.The People’s Republic of China（PRC）was founded in 1949,four years after the end of WWII.Since its establishment,the PRC has embarked on a road of peaceful development.展开更多
AIM:To develop an affinity peptide that binds to gastric cancer used for the detection of early gastric cancer.METHODS:A peptide screen was performed by biopanning the PhD-12 phage display library,clearing non-specifi...AIM:To develop an affinity peptide that binds to gastric cancer used for the detection of early gastric cancer.METHODS:A peptide screen was performed by biopanning the PhD-12 phage display library,clearing non-specific binders against tumor-adjacent normal appearing gastric mucosa and obtaining selective binding against freshly harvested gastric cancer tissues.Tumortargeted binding of selected peptides was confirmed by bound phage counts,enzyme-linked immunosorbent assay,competitive inhibition,fluorescence microscopy and semi-quantitative analysis on immunohistochemistry using different types of cancer tissues.RESULTS:Approximately 92.8% of the non-specific phage clones were subtracted from the original phage library after two rounds of biopanning against normal-appearing gastric mucosa.After the third round of positive screening,the peptide sequence AADNAKTKSFPV(AAD) appeared in 25%(12/48) of the analyzed phages.For the control peptide,these values were 6.8 ± 2.3,5.1 ± 1.7,3.5 ± 2.1,4.6 ± 1.9 and 1.1 ± 0.5,respectively.The values for AAD peptide were statistically signif icant(P < 0.01) for gastric cancer as compared with other histological classif ications and control peptide.CONCLUSION:A novel peptide is discovered to have a specific binding activity to gastric cancer,and can be used to distinguish neoplastic from normal gastric mucosa,demonstrating the potential for early cancer detection on endoscopy.展开更多
A series of urea-based compounds containing purine moieties were designed and synthesized as novel non-ATP competitive CHK1 inhibitors. The biological evaluation showed that several target compounds exhibited more pot...A series of urea-based compounds containing purine moieties were designed and synthesized as novel non-ATP competitive CHK1 inhibitors. The biological evaluation showed that several target compounds exhibited more potent inhibitory effects against CHK1 than the lead compound. In addition, one particular compound displayed synergistic effects with gemcitabine against HT29 cells.展开更多
文摘As one with great fame of writing China and Chinese people in war time, Anna Louise Strong, has the experience of communicating with Chinese left-wing writers, viewing their dramas works and reading their novels. From her perspective, Chinese left-wing literature was featured by its revolution and popularity; Chinese left-wing writers were busy with creating different genres to get every Chinese＇s involvement in the anti-Japanese war in 1930s and participation in the construction of new China in 1940s. Hence, they were multifarious in their identity because they cared more than literature in a turbulent time. From what she presented, China, as a cultural otherness, was the existent utooia that fulfilled her radical nolitical dream of communism.
文摘China commemorated on September 3,2014 the first official memorial day of the War of Resistance against Japanese Aggression and the anti-fascist war victory.The occasion affirmed the justice of the anti-Japanese war and China’s firm stance in safeguarding the achievements of WWII and maintaining world peace.The People’s Republic of China（PRC）was founded in 1949,four years after the end of WWII.Since its establishment,the PRC has embarked on a road of peaceful development.
基金Supported by The National Natural Science Foundation of China,No.81172359
文摘AIM:To develop an affinity peptide that binds to gastric cancer used for the detection of early gastric cancer.METHODS:A peptide screen was performed by biopanning the PhD-12 phage display library,clearing non-specific binders against tumor-adjacent normal appearing gastric mucosa and obtaining selective binding against freshly harvested gastric cancer tissues.Tumortargeted binding of selected peptides was confirmed by bound phage counts,enzyme-linked immunosorbent assay,competitive inhibition,fluorescence microscopy and semi-quantitative analysis on immunohistochemistry using different types of cancer tissues.RESULTS:Approximately 92.8% of the non-specific phage clones were subtracted from the original phage library after two rounds of biopanning against normal-appearing gastric mucosa.After the third round of positive screening,the peptide sequence AADNAKTKSFPV(AAD) appeared in 25%(12/48) of the analyzed phages.For the control peptide,these values were 6.8 ± 2.3,5.1 ± 1.7,3.5 ± 2.1,4.6 ± 1.9 and 1.1 ± 0.5,respectively.The values for AAD peptide were statistically signif icant(P < 0.01) for gastric cancer as compared with other histological classif ications and control peptide.CONCLUSION:A novel peptide is discovered to have a specific binding activity to gastric cancer,and can be used to distinguish neoplastic from normal gastric mucosa,demonstrating the potential for early cancer detection on endoscopy.
基金National Natural Science Foundation of China(Grant No.21302007)
文摘A series of urea-based compounds containing purine moieties were designed and synthesized as novel non-ATP competitive CHK1 inhibitors. The biological evaluation showed that several target compounds exhibited more potent inhibitory effects against CHK1 than the lead compound. In addition, one particular compound displayed synergistic effects with gemcitabine against HT29 cells.
